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Biomedical subjects

A Bussel

Publications and source records attributed to A Bussel.

At least 73 records · Page 4Linked to original sources
PubMed1981

[Value of plasma exchange in the management of acute immunoallergic thrombocytopenic purpura (author's transl)].

Plasma exchanges were performed in 5 patients with acute immunoallergic thrombocytopenic purpura (ITP) because of severe haemorrhages and/or inefficient or badly tolerated corticosteroid therapy. Plasma exchanges were carried out with cell separators and were usually well tolerated. They resulted in very rapid increase in platelet levels with disappearance of auto-antibodies and dramatic reduction of haemorrhages, and they brought about, or accelerated, recovery in 3 patients. One patient was slightly improved. In the 5th patient, who had meningeal haemorrhage, plasma exchange was effective in increasing platelet levels but was unable to prevent a fatal outcome. The main indications for plasma exchange seems to be acute ITP with severe, life-threatening haemorrhages.

Acute Disease↗
PubMed1980

Bone marrow transplantation in Fanconi anaemia.

Five patients with Fanconi anaemia have been treated by bone marrow transplantation from HLA identical donors. Only one patient survived for more than 3 years. She is now perfectly healthy with complete haematological reconstitution with chimaerism and disparition of chromosomal abnormalities. In contrast, four patients died of acute severe GVHD soon after grafting. In addition, all had signs of severe cyclophosphamide toxicity. This evolution could be explained by a special sensitivity of FA cells to alkylating agents and may indicate the need to modify the conditioning regimen in FA patients.

Anemia, Aplastic↗
PubMed1980

[Determination of anti-acetylcholine receptor antibodies in myasthenia and its treatment by plasma exchange and immunosuppressants].

Recent works have confirmed the auto immune mechanism in myasthenia gravis, that Simpson had hypothetized early as 1960. A post synaptic blockage, of which Ach-R antibodies seem to be chiefly responsible, is now accepted though the exact pathogenesis remains unknown. The immuno assay of these antibodies is still difficult; their blood level evaluates the course of the disease and the effectiveness of the treatment. The withdrawal of the antibodies by plasma exchange (P.E.) and the inhibition of their secretion by immunosuppression (I.S.) lead to remission in many cases. Principle of the immuno assay and results of P.E. and I.S. are reported in 21 cases.

Adolescent↗
PubMed1978

Cytomegalovirus infection in malignant blood diseases:clinical and laboratory data in 29 patients.

Twenty-nine patients treated for malignant blood diseases developped CMV infection. Their clinical and laboratory features were studied. The results indicated that this infection apparently did not influence the prognisis of the underlying disease. The main hematological feature was pancytopenia. The data of viremia suggested active infection. A marked increase of CMV CF antibodies were observed in 27/29 patients, and the peak titers of 42% of our cases were greater than 1:1024. Homogenous Ig were detected in 7/29 patient's serum.

Adolescent↗
PubMed1978

Allogeneic bone marrow transplantation in aplastic anemia--report of 25 cases.

Bone marrow transplantation using an HLA-MLC-identical sibling is the most valuable treatment of severe aplastic anemia.2,6,7 Between November 1973 and March 1977, 25 consecutive patients have been treated by marrow transplantation in our unit. Nine patients are alive with complete hematologic restoration between 3 months and 3 years. The high mortality can be largely accounted for by marrow graft rejection (14 patients). Despite the small number of patients, we have tried to identify prognostic factors associated with marrow graft rejection. They are mainly the existence of anti-HLA antibodies, the sex difference, and the normal PHA and MLC response before grafting. After the graft, the disappearance of anti-HLA antibodies has a good prognostic value. The appearance of autolymphocytotoxins seems to correlate strongly either with rejection or graft-versus-host disease.

ABO Blood-Group System↗
PubMed1977

[Altered platelet surface glycoproteins in chronic myeloid leukemia (author's transl)].

The present status of knowledge about the platelet membrane components suggests that glycoproteins (GP) are involved in the intercellular platelet specific reactions, such as adhesion and aggregation. Normal human platelets and platelet membranes solubilized under dissociating conditions produce characteristic polypeptide and GP electrophoretic patterns (PAGE). Platelets and isolated platelet membranes from patients with chronic myeloid leukemia (CML) presented dissimilarities of their glycoconjugates as compared to the normal platelets. The modification of the electrophoretic banding visualized by the periodic acid-Schiff's reagent (PAS) consisted in the decrease of the 155,000 GP L, the presence of two PAS positive bands in the area of the 135,000 normal PAS positive GP LL and a variable decrease of the 100,000 GP LLL (Apparent mol. wt. are indicated). In addition, preliminary data showed an increased catalytic transfer of the labelled galactosyl and N acetygalactosaminyl residues from exogenous nucleotide 14C-sugar precursors onto the CML-platelet endogenous sugar acceptors. These firstly reported data on molecular abnormalities of the platelet membrane GP in CML, suggested their possible relationship with the impaired platelet adhesion and aggregation occurring in this disease or the ability of leukemic platelets to express modified surface membrane components.

Adult↗