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Biomedical subjects

A C Arnold

Publications and source records attributed to A C Arnold.

At least 37 records · Page 2Linked to original sources
PubMed1994

Natural history of nonarteritic anterior ischemic optic neuropathy.

Visual acuity and quantitative perimetry (Octopus Program 32) testing was performed in the acute (< 30 days after onset) and convalescent (> 3 months after onset) phases of disease in 27 patients with untreated NAION. Initial group mean acuity and sensitivity loss were compared to final values using the t test. Proportions of patients demonstrating a change of > 2 lines acuity or > 2 dB mean sensitivity were calculated. Patients were classified as either "progressive" (n = 6) or "stable" (n = 21) for purposes of additional subgroup analysis. There was no significant change in group mean visual acuity or field over time. Overall, significant worsening occurred in 11.1% for visual acuity and 22.2% for visual field; improvement occurred in 23.8% for acuity and 24.0% for field. Of 21 "stable" patients, none worsened for acuity and 4.7% showed late worsening of field; 31.3% showed significant improvement for acuity and 31.6% for field. No "progressive" patients demonstrated worsening or improvement after the initial progressive phase.

Aged↗
PubMed1994

Incidence of nonarteritic and arteritic anterior ischemic optic neuropathy. Population-based study in the state of Missouri and Los Angeles County, California.

This population-based study was undertaken to obtain information on age-, sex-, and race-specific incidence of nonarteritic and arteritic anterior ischemic optic neuropathy for the State of Missouri and for Los Angeles County, California. Among subjects who were 50 or older the estimated mean annual incidence rates per 100,000 population were 2.30 for nonarteritic anterior ischemic optic neuropathy and 0.36 for arteritic anterior ischemic optic neuropathy. White individuals appear to be at significantly higher risk of developing nonarteritic anterior ischemic optic neuropathy than black or Hispanic individuals, suggesting possible genetic predisposition.

Acute Disease↗
PubMed1991

Immunopathologic features of retinal lesions in multiple sclerosis.

To further characterize the nature of retinal periphlebitis and retinitis in multiple sclerosis, immunoperoxidase studies were performed on retinal tissue from multiple sclerosis patients at autopsy. Antibodies against myelin basic protein stained the optic nerve but not the retina. Both normal and multiple sclerosis retinas showed staining of Müller cells with Leu-7 (a monoclonal antibody that cross-reacts with myelin associated glycoprotein and natural killer cells). Nerve fiber bundles of the optic nerve in cases with multiple sclerosis and controls also showed staining with Leu-7 antibody. Tissue-bound IgG was demonstrated on retinal ganglion cells in six of seven multiple sclerosis cases but not in controls.

Antibodies, Monoclonal↗
PubMed1990

Internuclear ophthalmoplegia in the Chiari type II malformation.

We describe 3 cases of Chiari type II malformation presenting with bilateral internuclear ophthalmoplegia (INO). Although prominent, the INO was not an isolated sign in any of the patients; superimposed abduction paresis was present in 2, and deficits in smooth pursuit, optokinetic nystagmus, and vestibulo-ocular responses were present in 3. Two had hydrocephalus: 1 was clinically unchanged without therapy after 5 years; the other did not improve with shunting. Findings in our 3 patients, along with the 4 previously reported, confirm that INO is 1 manifestation of widespread brainstem or cerebellar dysfunction. Its origin is probably multifactorial, related to hydrocephalus, vascular compromise, direct neuronal distortion, or congenital neural malformation.

Adult↗
PubMed1990

Giant papillary conjunctivitis associated with elevated corneal deposits.

A patient presented with central corneal scarring and neovascularization associated with elevated deposits that were shown to be keratin and calcium. Giant papillary conjunctivitis (GPC) was noted at a corresponding location in the palpebral conjunctiva. The lid reaction resolved after the elevated corneal deposits were debrided. A rigid gas-permeable contact lens was then fitted for visual rehabilitation. Either foreign bodies or elevated corneal deposits may cause GPC.

Adult↗
PubMed1990

Internuclear ophthalmoplegia from intracranial tumor.

Bilateral internuclear ophthalmoplegia (INO) is most often demyelinative in origin. Rarely, structural lesions may present with this finding, but in these cases the age at onset and the associated signs of increased intracranial pressure and widespread brainstem dysfunction usually make the distinction. This report describes the 13th published case of tumor-induced INO, produced by an atypical adult medulloblastoma. Potential pathophysiologic mechanisms are discussed.

Adult↗
PubMed1986

Botulinum toxin for the treatment of dysthyroid ocular myopathy.

Eight consecutive patients with acquired deviations due to dysthyroid ocular myopathy were injected with botulinum A toxin for relief of their diplopia. Seven patients were acute in the onset of symptoms and one was chronic. All showed improvement in motility and experienced a reduction if not total relief of their symptoms. Six patients required reinjection. Complications were limited to transient ptosis, transient involvement of adjacent muscles and transient but prolonged paralysis that eventually resolved. No systemic complications were noted. We conclude that chemodenervation with botulinum A toxin may have a role in the management of dysthyroid ocular myopathy not amenable to prism treatment and may act as an adjunct to or eliminate the need for surgical correction in some patients.

Adult↗
PubMed1986

Anterior encephalocele presenting as nasolacrimal obstruction.

A case of congenital anterior encephalocele presented originally with nasolacrimal obstruction. Associated paranasal masses and hypertelorism suggested the diagnosis, which was confirmed and delineated by computed tomography. Anterior encephalocele has various clinical presentations, but the diagnosis should be suspected in a child with nasolacrimal obstruction and associated congenital anomalies, particularly paranasal masses. Early recognition is essential to prevent trauma to CNS tissue, to prompt evaluation for other congenital anomalies, and to facilitate appropriate neurosurgical repair.

Child, Preschool↗
PubMed1986

Botulinum toxin for the treatment of essential blepharospasm.

Twenty-six patients with essential blepharospasm were treated with botulinum toxin by injection. The onset of protractor weakness in all patients ranged from one to five days following treatment. Maximal weakness developed within 12 days. There was a variable and gradual return of protractor strength over eight to 29 weeks in most patients and, with it, a return of spasm. Twenty-five patients received some degree of functional relief following initial injection. In most patients, however, the post-injection result could not be stabilized and repeat injections have been necessary to control recurrent spasms. There was one treatment failure. Three patients treated by injection following previous neurectomy and myectomy appeared to have a reduced requirement for subsequent injections. Complications included transient ptosis in six patients and mild exposure symptoms in four patients. Extraocular muscle paresis did not occur. There were no systemic side effects from the botulinum toxin injections.

Aged↗
PubMed1985

Metastatic eyelid carcinoma.

Two cases of carcinoma metastatic to the eyelid are described. The first was derived from a lung primary diagnosed two months prior and presented as a solitary tender mass mimicking an acutely inflamed recurrent chalazion. The second case was the initial manifestation of a stomach carcinoma, presenting as a solitary painless nodule. Both were part of generalized metastatic disease; survival was six weeks and five months, respectively, after eyelid tumor presentation. Excisional biopsy was effective palliation in the first case, but multiple operations were required in the second. The clinicopathologic features are discussed and the prior reported cases reviewed.

Adenocarcinoma↗
PubMed1984

Retinal periphlebitis and retinitis in multiple sclerosis. I. Pathologic characteristics.

Eyes from 47 autopsy cases of multiple sclerosis were studied pathologically. Lymphocytic or granulomatous retinal periphlebitis was found in four cases (seven eyes); focal lymphocytic or granulomatous retinitis was present in three cases (five eyes). These findings were correlated with optic nerve changes (periphlebitis, neuritis, leptomeningitis, and atrophy), retinal venous sclerosis, uveitis, central nervous system involvement, clinical activity of disease at death, and with ultrastructural and immunopathological retinal findings.

Humans↗
PubMedDate not supplied

Isolated metastasis to the optic nerve.

A case of isolated optic nerve metastasis from breast carcinoma is described. Intraocular tumor was discovered three months following a radical mastectomy and was confined to the optic nerve head and distal optic nerve. Following X-irradiation treatment, central retinal vascular occlusion, rubeosis, and neovascular glaucoma developed during the fifteen months before enucleation. The clinicopathologic features of this case are discussed and the literature reviewed.

Adult↗