Biomedical subjects
Publications and source records attributed to A C Branfoot.
We describe a case of PLEVA in an asymptomatic, human immunodeficiency virus (HIV) positive patient. This association has not been previously described. The possible mechanisms involved are discussed.
Carcinoma of the pancreas has been associated with both cicatricial and bullous pemphigoid. We report a case of a 53-year-old man with cicatricial pemphigoid who died within months of the diagnosis from metastatic pancreatic-carcinoma. All three reported cases were complicated by venous thrombosis, a well recognized but uncommon feature of pancreatic cancer.
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Erythema elevatum diutinum is a rare disease of unknown aetiology. It is usually symmetrical with multiple lesions. An association with rheumatoid has previously been reported. We report a case of atypical erythema elevatum diutinum affecting the right elbow of a female patient with seropositive rheumatoid arthritis.
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The mucosa in 100 segments of colon and rectum resected for cancer were examined using light microscopy and histochemical techniques. The extent of abnormal or transitional mucosa was defined for each case. Transitional mucosa was present in 93 of 95 adenocarcinomas and one malignant melanoma. The average total length of transitional change was 3.4 cm the maximum length was 19.5 cm. An inverse correlation was observed between the survival and the length of transitional mucosa around locally invasive (Dukes' B) carcinomas (P = 0.005). This may be related to increased amounts of sialic acid in transitional mucosa and the ability of sialic acid to depress tumor immunogenicity. The raised levels of sialic acids in transitional mucosa may have practical value in assessment of prognosis in colorectal cancer.
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Pancreatic oncofoetal antigen (POA) has been isolated by affinity chromatography and used to standardise an immunoassay. POA was detected in foetal serum and in 97% of sera from 75 patients with carcinoma of the pancreas. Raised levels were also found in 16% of sera from 43 patients with chronic pancreatitis and in 3 of 156 patients with related conditions. Using an immunoperoxidase method, POA was regularly found in the foetal pancreas and in adult carcinoma of the pancreas. Weak staining was found in the foetal pancreas and in adult carcinoma of the pancreas. Weak staining was found in one carcinoma of the colon. Antisera from two other groups (Gelder and Moossa; Arndt and Thiele) react with the same antigenic moiety as does our anti-POA.
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