Biomedical subjects

A C Doriguetto

Publications and source records attributed to A C Doriguetto.

6 recordsLinked to original sources

PubMed2006

A duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity tests.

A duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5'-dinitro-2-(2,3-diaza-4-(2'-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasii, although it had a high level of mutagenicity, as observed in mutagenic activity tests.

Antitubercular Agents↗

PubMed2005

The synthesis and characterisation of Sn(IV) complexes of 2,6-pyridine dicarboxylate--the molecular structure of divinyltin(IV) derivative.

A series of organotin(IV) derivatives were obtained employing 2,6-pyridinedicarboxylate as ligand: [{SnBu3(OOC)2C5H3N}n] (1), [SnBuCl(OOC)2C5H3N] (2) and [Sn(CHCH2)2(OOC)2C5H3N] (3). They were fully characterised by multinuclear NMR [1H, 13C{1H}, and 119Sn{1H}], IR spectroscopies and elemental analysis. In addition suitable crystals of (3) have shown a dimmeric arrangement by X-ray crystallographic studies, held together by Sn-O intermolecular interactions which persists in solution. The crystal packing shows hydrogen bonds joining the dimmers, forming two infinite one-dimensional chain. Each monomer comprises a Sn(IV) centre bonded to a pyridinecarboxylate-containing ring, through both nitrogen and oxygen donor atoms. It is also co-ordinated by a water molecule and two vinyl groups.

Carbon↗

PubMed2004

The effect of the cation substitution on the structural and vibrational properties of Cs2NaGaxSc(1-x)F6 solid solution.

Raman scattering and x-ray diffration were used to characterize the structural and vibrational properties of the Cs2NaGaxSc(1-x)F6 solid solutions, for x ranging from 0.0 to 1.0. The Raman spectra, taken at room and low temperature, allow us to follow the phase evolution in detail and indicate the breaking of the local symmetry since low Ga concentration levels. Five compositions were studied by x-ray diffraction: x = 0.0, 0.2, 0.5, 0.8, and 1.0. A cubic space group, Fm3m, was found to x = 0.0 and x = 0.2 and a trigonal one was found to x = 0.5, 0.8, and 1.0. Details of both phases are presented and the correlation between x-ray diffraction and Raman scattering is discussed.

Journal Article↗

PubMed2004

The synthesis and structural characterisation of [Ru(eta-Cp)(dppf)SnBr3].

The reaction of [Ru(eta-Cp)(dppf)N(3)] (1) with equimolar amount of SnBr(2) yielded an interesting heterotrimetallic compound [Ru(eta-Cp)(dppf)SnBr(3)] (2) (dppf: 1,1'-bis-diphenylphosphinoferrocene). Compounds 1 and 2 were characterised by IR, NMR (1H, 13C, 31P and 119Sn), and 2, additionally, by 57Fe and 119Sn Mössbauer spectroscopy and X-ray crystallography. The latter results were as follows: monoclinic, C2/c, a = 32.8879(4)A, b = 11.9888(2)A, c = 20.8986(3)A, beta = 92.545(1)degrees, V = 8231.9(2)A(3), Z =8.

Bromine↗

PubMed2001

Structural transition and pair formation in Fe3O2BO3.

We observe for the first time a structural phase transition in the oxyborate Fe3O2BO3 which occurs along three leg ladders present in this material. X-ray diffraction shows that this transition at 283 K is associated with a new phase where atomic displacements occur in alternate directions perpendicular to the axis and within the plane of the ladders. Magnetic data show that these displacements lead to the formation of singlet pairs which dissociate close to the structural transition. Anomalies in the transport properties also occur close to 283 K showing that the structural transition is related to a charge ordering phenomenon in a low dimensional structure.

Journal Article↗

PubMed2001

6-Deoxyjacareubin.

The natural compound 5,10-dihydroxy-2,2-dimethylpyrano[3,2-b]xanthen-6(2H)-one (6-deoxyjacareubin), C(18)H(14)O(5), was isolated from leaves of Vismia latifolia (Guttiferae family). The compound has four six-membered rings. The molecule has two planar benzenoid and one planar pyranoid ring, plus a pyranoid ring in a distorted chair conformation. The crystal is stabilized by one intra- and one intermolecular hydrogen bond.

Crystallography, X-Ray↗