PubMed Health⌕ Search

Biomedical subjects

A C Glasser

Publications and source records attributed to A C Glasser.

8 recordsLinked to original sources
PubMed1984

From empirical structure modifications to QSAR.

The development of man's search for drugs from prehistoric times to the utilization of computerized Quantitative Structure-Activity Relationships is outlined in brief historical fashion. The development of the Hansch concept and the use of multiple regression analysis and the partition coefficient parameter are described in detail along with select examples of the use of the Hansch equation. Additional methods such as the Free-Wilson de novo method, as well as those ranging from the non-computerized methods of Topliss and Darvas to quite sophisticated interactive computer graphics, are presented in review.

Humans↗
PubMed1981

Improved assay for mixtures of citrate and citric acid in systemic alkalizer solutions.

A modification of the USP method for the assay of systemic alkalizer solutions containing mixtures of citrate and citric acid is presented; it involves two titrations and ion-exchange chromatography. A diluted sample is tritiated with 0.02 N NaOH to find the free citric acid content. The eluate from cation-exchange chromatography of an equal volume of diluted sample is titrated with 0.02 N NaOH to assay for total citric acid. Subtracting the results of the first titration from the second provides the citrate content. Synthetic mixtures of potassium citrate-citric acid, potassium citrate-sodium citrate-citric acid, and sodium citrate-citric acid were prepared and assayed. The method was applied to commercially available preparations. The proposed method eliminates some significant errors of the compendial method, and the accuracy and reproducibility are equal or better than those obtained with the compendial method. Theoretically, the result obtained by the compendial method does not necessarily give the citrate content.

Chromatography, Ion Exchange↗