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Biomedical subjects

A C Hansen

Publications and source records attributed to A C Hansen.

At least 19 recordsLinked to original sources
PubMed1992

[Salicylic acid poisoning].

The study analyses the role of salicylic acid (SA) in fatal intoxications with special reference to potentially avoidable, accidental poisonings. The study indicates a relation between SA intoxication and the presence of an infection of the respiratory tract. All deaths in Denmark in the period 1980 through 1989 registered as caused by SA were analysed as were all deaths submitted to forensic toxicological examination in a defined region of Denmark in the years 1985 through 1989. During the decade 1980 through 1989 the number of fatal intoxications due to SA increased from approx. five per year to approx. 23 per year. During the same period the sales of SA decreased. Many deaths in the material were registered as accidental, and an increasing frequency of accidental deaths was seen with a lower social level. Frequently, an infection of the respiratory tract was either indicated in a hospital case record or a police report, or found at autopsy.

Adult↗
PubMed1991

[Deaths due to poisoning in Denmark in 1983-1987].

Deaths due to poisoning in Denmark during the five-year period 1983-1987 are described on the basis of the information from the register of causes of deaths in the Danish Institute of Clinical Epidemiology. The average annual number of deaths due to poisoning was 935.63% of these were suicides, 21% accidents, less than 1% manslaughter and in 16% of the cases the manner of death had not been established. 68% were due to medicaments, nearly half of these unspecified, 25% were due to carbon monoxide, 5% to alcohol, and 2% to other causes. The value of this account is restricted by the fact that not all of these deaths were submitted to medico-legal investigation, and that there were technical limitations in the classification and coding of causes and manners of death. In this connection, it is emphasized that almost one third of the deaths due to poisoning were caused by an unknown medicament. Differences in manners and causes of death are noted by comparing the results of this account to the material from the institutes of forensic medicine concerning chemically investigated deaths due to poisoning. This account applies to the prophylaxis of deaths due to poisoning, with special reference to medical drugs in general, carbon monoxide, alcohol, alcohol in combination with medicaments or narcotics, and over-the-counter analgesics containing acetylsalicylic acid. It is concluded that a more carefully examined representative material is required.

Cause of Death↗
PubMed1990

[Treatment of acute chloroquine poisoning].

Acute chloroquine poisoning is life threatening with risk of death from apnoea and cardiac arrhythmia within a few hours of ingestion. Mechanical ventilation, infusion of pressor agents and large doses of diazepam seem to provide effective treatment. This treatment was introduced by Riou et alii (N Engl J Med 1988; 318; 1-6), and we used it successfully in a case of severe chloroquine poisoning. Intensive treatment was given during the first two days of intoxication, when the whole blood chloroquine phosphate concentration was high (more than 10 mumol/kg), corresponding to absorption from the gut and distribution to the organs. Hereafter the whole blood chloroquine phosphate concentration decreased increasingly slowly, probably due to equilibrium with tissue stores.

Acute Disease↗
PubMed1989

[Measurement of alcohol in saliva with a test strip].

As the concentration of alcohol in saliva follows the concentration of alcohol in the blood meticulously, a test strip to measure alcohol in saliva would provide an easy and rapid method of semiquantitative estimation of the blood alcohol concentration. The authors have submitted Alco-Screen test strips to trial by comparing five different batches by measurement on aqueous solutions of alcohol, saliva to which alcohol had been added and also in practice. The batch variations were very great and the results obtained on aqueous solutions and saliva with added alcohol were too high whereas the results in practical use were, in general, too low. In addition, it was found that the colour of the reagent field was difficult to compare with the reference fields. Instructions for use were incomplete and easily misunderstood.

Adult↗
PubMed1984

Lymphocyte counting by cell size distribution analysis of leucocytes compared with conventional blood film differential count.

The fourteen parameter Coulter Counter S-Plus IV automated haematology analyser includes the innovative capability of calculating the percentage and number of lymphocytes in the leucocyte population. These features have been evaluated. The percentage of lymphocytes ( LYP ) correlates well to that of the conventional blood film differential count (CDC) and the reproducibility and linearity is excellent. The reproducibility exceeds that of the CDC and it is proposed that with a few safeguards the accuracy also is superior. The reason for possible erroneous LYPs are discussed and the safeguards to detect them are described. It is suggested that in cases where information on the percentage of lymphocytes (or granulocytes) is sufficient the CC LYP may replace the CDC. Use of LYP may reduce the number of CDCs to be performed by 50-75%.

Autoanalysis↗
PubMed1984

Interference by cold agglutinins with the measurement of particle concentrations in the Coulter Counter Model S-Plus IV.

Cold agglutinins may interfere with measurement of red cell indices in the Coulter Counter Model S-Plus IV due to aggregation of erythrocytes. This is most easily detected by a mean erythrocyte haemoglobin concentration (MCHC) raised above 22.7 mmol/l (established by experience). Heating of the samples will normalize the values in most cases. Temperature-dependent red cell indices were not found in approximately 100 samples with MCHC between 19.5 mmol/l and 22.7 mmol/l. Aggregation of and interference with measurement of white cells and platelets has not been observed.

Agglutinins↗