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Biomedical subjects

A C Iplikçioğlu

Publications and source records attributed to A C Iplikçioğlu.

At least 19 recordsLinked to original sources
PubMed2004

Phenytoin penetration into chronic subdural haematomas.

The pathophysiology of chronic subdural haematomas (CSH) is still unclear. In the light of recent ultrastructural examination, exudation from the macrocapillaries in the outer membrane of CSH may play an important role in the enlargement of CSH. In this study, exudation from the macrocapillaries was assessed by the measurement of phenytoin, a protein-bound antiepileptic agent used in cases of CSH. In 22 patients, 1 h after the administration of 250 mg of phenytoin intravenously, blood and subdural haematoma samples were taken and phenytoin levels were measured. The ratio of subdural haematoma level to the blood phenytoin level was determined and defined as the phenytoin penetration ratio (PPR). The correlation between the phenytoin penetration ratio and clinical neurological grades (Markwalder and Glasgow Coma Scale), age of the patients and the CT appearance of CSH were investigated. The mean phenytoin penetration ratio was 19.5%. As the neurological grades of patients increased, average PPR also increased. The average PPR values were 17.64 and 20.84% in the patients younger than 60 years (nine patients) and older patients (13 patients), respectively. Mean PPRs in the groups according to the CT appearance were as follows: low density 11.21% (seven patients), isodensity in 15.88% (10 patients), high density in 38.5% (five patients). A subdural reaccumulation was detected in nine patients with a mean PPR of 27.72%, while mean PPR was 14.56% in the others. Exudation from macrocapillaries in the outer membrane of chronic subdural haematomas probably plays an important role in the enlargement of chronic subdural haematoma, and measuring phenytoin levels in the chronic subdural haematoma is a simple method for the quantitative estimation of the exudation in CSH.

Adult↗
PubMed2000

The effect of tizanidine on chronic vasospasm in rats.

BACKGROUND: Cerebral vasospasm after subarachnoid hemorrhage (SAH) has remained a major cause of morbidity and mortality in patients with SAH. Excitatory neurotransmitters are gathered in the extracellular space during ischemia due to cerebral vasospasm and initiate or stimulate a series of pathophysiological biochemical processes which consequently lead to neuronal death. Tizanidine (Sandoz compound DS 103-282, 5-chloro-4,2 (2-imidazolin-2-yl-amino)-2,1,3-benzothiazol hydrochloride) is a centrally-acting muscle relaxant and a selective alpha 2 adrenoreceptor agonist which shows its effect by stimulating presynaptic alpha 2 adrenoreceptors in central ASPergic and GLUergic system by inhibiting aspartic acid and glutamic acid release. In this study, the effect of Tizanidine on vasospasm was evaluated. METHODS: We used a femoral artery vasospasm model in rats which has been described by Okada et al. 60 rats were examined in three groups. The first group was used as control group (Control) (n = 20), in the second group subarachnoid hemorrhage was performed (SAH) (n = 20), in the third group Tizanidine was administered in addition to SAH (SAH + Tizanidine administration) (n = 20). Animals in SAH + Tizanidine administration group received 0.3 mg/kg/day intraperitoneally for 7 days. Seven days after the experiment, after perfusion-fixation, 10 mm segments of both femoral arteries were removed and the femoral artery was prepared for light microscope examination, scanning and transmission electron microscopy and for morphometric analysis. RESULTS: There was a statistically significant difference between the electron, scanning and light microscopic observations and morphometric analysis of SAH + Tizanidine administration group and SAH group, and no statistically significant difference between SAH + Tizanidine administration group and control group. CONCLUSION: This study has disclosed that Tizanidine administration before the vasospasm reduces ultrastructural and morphometric vasospastic insult significantly. However, the clinical application of Tizanidine as a protective and therapeutic agent in cerebral vasospasm needs further studies including the employment of clinically more relevant SAH models.

Adrenergic alpha-2 Receptor Agonists↗
PubMed1997

Supratentorial haemangioblastoma: appearances on MR imaging.

Haemangioblastoma is a rare, benign tumour of vascular origin which usually occurs in the posterior fossa. Supratentorial haemangioblastomas are exceptionally rare. In this report we present three cases of supratentorial haemangioblastoma with MRI findings.

Adult↗
PubMed1994

A fluid level in an acute extradural haematoma.

We report a fluid level in an acute extradural haematoma developing after placement of a ventriculo-peritoneal shunt for hydrocephalus. This fluid level was thought to be due to a mixture of blood and cerebrospinal fluid.

Acute Disease↗
PubMed1994

Growing skull fracture of the orbital roof.

One year after trauma, diplopia, limitation of ocular movements on the left side, orbital asymmetry, and a growing skull fracture on the orbital roof were reported in an extraordinary case. While presenting this extraordinary localization of growing skull fractures, the anatomy, pathogenesis and the natural evolution of these lesions still remain obscure.

Child↗
PubMed1994

Magnetic resonance imaging in cervical trauma associated with ankylosing spondylitis: report of two cases.

Findings on magnetic resonance imaging (MRI) in two cases of traumatic cervical fracture associated with ankylosing spondylitis are presented. In such patients cervical fracture usually occurs in the lower cervical spine from hyperextension injuries. Classic radiologic investigations including plain films, myelography, and computed tomography are insufficient because of osteopenia and distorted anatomy: MRI is superior to other techniques.

Cervical Vertebrae↗
PubMed1994

Interhemispheric subdural haematomas.

Eight cases of interhemispheric subdural haematomas (ISDHs) are described. Trauma was the most common cause. Two patients were hydrocephalic and one of them had also agenesis of the corpus callosum. The diagnoses were established by CT. In one of the cases with chronic ISDHs, CT findings suggested a subdural empyema. Conservative treatment was preferred for neurologically stable patients. In one of the patients, the haematoma migrated to the cerebral convexity after liquefaction.

Adult↗
PubMed1991

Ossified chronic subdural hematoma: case report.

A case of ossified chronic subdural hematoma is presented in a 13-year-old male in whom the mass was surgically removed. His neurological deficits continued afterward but were less severe.

Adolescent↗