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Biomedical subjects

A C Joosting

Publications and source records attributed to A C Joosting.

16 recordsLinked to original sources
PubMed1980

Serum antibody levels after immunization with trivalent oral poliovirus vaccine.

The antibody titres to the polioviruses after three doses of trivalent oral poliovirus vaccine were assessed in 77 Coloured children aged 3-9 months. Neutralizing antibody titres of 1 in 10 or greater to all three types were found in 59 (77%) of all children. The remaining 18 children lacked demonstrable antibody to one or more of the polioviruses. Antibody to types 1 and 3 was most commonly lacking. The possible reasons for the failure of vaccination in so many children is discussed. Studies of the effect of further doses of vaccine on serum antibody levels are recommended.

Antibodies↗
PubMed1979

Mumps virus and ovarian cancer.

Thirty-four patients with carcinoma of the ovary were compared with controls matched for age, sex and racial origin. Previous mumps infection was determined by taking a history from the patient, by complement fixation test and by estimating neutralizing antibody titre. No significant differences between the two groups were found for any of the three methods used to estimate previous exposure to mumps virus. Therefore this study did not confirm previous hypotheses that mumps infection confers a significant degree of protection against the development of ovarian cancer. A relatively small proportion of cases could possibly be due to lack of such protection, but in this study not more than 30% at the 5% fiducial limit.

Adenocarcinoma↗
PubMed1979

Respiratory viruses in hospital patients on the Witwatersrand. A 7-year study.

Virological investigations were carried out on 4 151 patients with respiratory disease hospitalized between May 1966 and April 1972. The groups examined were Black and White children and Black miners. Influenza viruses were more common among malnourished Black children and tended to cause more severe disease. This was also true of adenovirus and Herpesvirus hominis type 1 infections. Adenoviruses appear to be secondary invaders, frequently after a measles or influenza attack. A generalized epidemic of adenovirus type 7 occurred in 1967, the longest, coldest and most humid winter during the survey. The season of peak occurrence for respiratory syncytial (RS) virus is autumn, not winter as found elsewhere. The parainfluenza viruses differ from each other, types 1 and 2 being commoner in older children (12--48 months), mainly causing laryngotracheobronchitis (LTB), whereas type 3 is commoner in younger children (0--23 months), mainly causing pneumonia. The miners showed a preponderance of influenza A infections. The miners' origin from remote villages and high turnover rate create a situation where a given strain will persist at a moderate level for long periods, unlike in the general population where an outbreak lasts for only about 6--8 weeks. As opposed to other closed communities, adenovirus infections were rare. The reason for this is obscure.

Adenoviridae↗
PubMed1976

A serological investigation of Mycoplasma pneumoniae infection on the Witwatersrand.

Sera from patients with respiratory disease were examined for antibody to Mycoplasma pneumoniae by complement fixation test. During the study period of about 6 years, a 3-year cycle of infection was observed, which coincided with some epidemics in the UK and USA, suggesting the possibility of an approximately simultaneous world-wide spread. The epidemics lasted about 18 months each, during which the incidence of infection was over 10 times that of the interepidemic periods.

Antibodies, Bacterial↗
PubMed1973

Influenza in 1973.

Explore the source record for details and available documents.

Antibodies, Viral↗
PubMed1968

Production of common colds in human volunteers by influenza C virus.

Influenza C virus was intranasally administered to volunteers; most were infected and nine developed symptoms of common cold.Increasing titres of serum haemagglutination-inhibiting antibody and complement-fixing antibody were detected. Virus neutralizing activity in nasal secretion was not correlated with either resistance to infection or the occurrence of overt illness. Interferon was detected in the nasal secretions of some subjects.

Antibodies↗