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Biomedical subjects

A C Koeger

Publications and source records attributed to A C Koeger.

At least 73 records · Page 4Linked to original sources
PubMed1986

[Sulfhydryl maintenance treatment in rheumatoid polyarthritis. A series of 120 cases followed for 10 years and a study of possibilities of changing the drug].

The authors present a series of 120 cases of sero-positive rheumatoid arthritis followed for ten years and treated with D-penicillamine, gold salts and pyrithioxine used either alone or sequentially after stopping one of these treatments because of failure, intolerance or escape. This series can be broken down as follows: 13% of patients are under treatment after ten years, 27% had a favourable result with one of the three treatments for five to ten years, 59% had a poor result (less than 5 years) or no effect. However, it appeared that a failure or an escape from one of these products did not signify a failure with another product and side effects did not necessarily recur with a change of treatment.

Adult↗
PubMed1985

[Tumoral hypophosphoremic osteomalacia].

Various tumoral diseases may induce hypophosphataemic osteomalacia. This is the case, in particular, with mesenchymal tumours and sclerosing metastases of prostatic cancer; much less common causes are diffuse connective tissue dysplasias and non-prostatic epitheliomas. Depending on whether osteomalacia results from a mesenchymal tumour or from osteitis of prostatic origin, the practical problems encountered are quite different. In the first case, the important point is not to miss a mesenchymal tumour when confronted with an acquired and apparently idiopathic hypophosphataemia; repeated examinations at regular intervals are sometimes necessary to detect the tumour which is usually benign; osteomalacia can then be cured by its removal. In the second case, the difficulty is to detect an osteomalacia which may be masked by bone metastases and to recognize its tubular origin in order to prescribe the appropriate treatment. Little is known about the pathogenesis of tumoral hypophosphataemic osteomalacia. The renal diabetes and low 1,25 (OH)2 D plasma levels frequently associated with the disease reflect a complex enzymatic disorder thought to be caused by a humoral mediator secreted by the tumour. Studies carried out in this field have already shown that 1,25 (OH)2 D is therapeutically useful when the tumour cannot be excised.

Bone Diseases↗
PubMed1985

[Vertebral and thoracic osteoarticular manifestations in palmoplantar pustulosis].

Two cases of inflammatory joint disease during attacks of aseptic palmo-plantar pustulosis are reported. Both patients had vertebral involvement: disco-vertebral erosions at several levels in one case and spondylitis and intersomatic ossification in the other. One patient also had sacroiliitis and involvement of the anterior thoracic skeleton (costoclavicular joints, costal cartilages ans xiphoid) confirmed by bone scintigraphy. The relation between this cutaneous-articular syndrome and other inflammatory joint diseases, especially ankylosing spondylitis and psoriatic arthropathy are discussed. The very unusual involvement of the anterior thoracic skeleton, the coexistence of aseptic palmo-plantar pustulosis and absence of antigens HLA B27, B13 and B17 suggest a similarity to the pustular osteoarthritis recently described by Japanese workers who grouped this condition with other spondylarthropathies.

Adult↗
PubMed1984

[Biological study of spontaneous amyloidosis in PS mice].

A remarkably severe spontaneous amyloidosis involving multiple organs has characterized the inbred PS mouse strain since the 25th generation. The amyloid substance was extracted with H2O and purified by successive gel filtrations on Sephadex G100, Sephadex G10 and Biogel P4. It was submitted to biochemical, immunochemical and histochemical analysis in order to determine its origin. Potassium permanganate resistance of the affinity for Congo Red dye, aminoacid composition, cross-reactivity with anti-mouse light chains antisera suggested an amyloidogenic process comparable to that described for the AL substance in man. However, even if abnormal lymphoid infiltrates were present in several organs, the presence of M component could not be demonstrated in serum or urine of these mice. This indicated either a limited tumoral mass or a tumor poorly secreting a precursor that would be strongly amyloidogenic. Alternatively, the existence of a so far unidentified precursor could not be excluded.

Amyloid↗
PubMed1984

[Cranial localizations of sarcoidosis. Apropos of a case. General review of the 21 reported cases].

A case of sarcoidosis with lesions also localized to the cranial region is reported, and 21 similar cases published in the literature reviewed. Lesions are usually seen as small lacunae in the cranial vault, and are commonly associated with neurologic and cutaneous manifestations of the disease. They appear to be very rare but their frequency is probably underestimated. Their detection is facilitated by the use of technetium scintigraphy.

Adult↗
PubMed1983

[Double-blind comparative study of Bi-Profenid tablets and Profenid capsules in inflammatory rheumatism].

The effectiveness of Bi-Profenid tablets and Profenid capsules was studied comparatively in patients with inflammatory joint disease. 43 patients with rheumatoid arthritis or various chronic inflammatory joint diseases were given 300 mg of Bi-Profenid in 2 daily oral doses and 300 mg of Profenid in 3 daily oral doses, for two consecutive 7 day periods. This double blind cross-over study was carried out in two rheumatology centers. Effectiveness of the two forms of ketoprofen on morning stiffness and pain scale was found to be comparable. However, patients more often preferred Bi-Profenid (15 cases) to Profenid (10 cases); 12 patients reported no difference. Tolerance was excellent in 92.7% of cases under Profenid capsules and in 94.8% of cases under Bi-Profenid tablets.

Adolescent↗
PubMed1983

[Treatment of gout].

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Combined Modality Therapy↗
PubMed1983

[Physiology and main implications of magnesium in osteo-articular pathology].

The role of magnesium in the constitution, metabolism and hormonal control of bone tissue can be deducted from what is known of its physiology. Magnesium deficiency may result in vitamin-D resistant hypocalcaemia or even biochemical signs of hypoparathyroidism, which only regress after the deficiency is corrected. Measurements of magnesium levels in blood and urine are justified when such abnormalities occur in patients with digestive disorders, predominantly alcoholism, liver diseases or malabsorption. In all other circumstances, magnesium therapy is very rarely indicated for osteo-articular diseases.

Animals↗
PubMed1983

[Articular manifestations of Whipple's disease. A case of sacroiliitis and destructive coxopathy].

Whipple's disease is a systemic illness whose pathogenesis, which is still poorly understood, implies an infectious agent accessible to antibiotic therapy. The authors report a case which is made unusual by the manifold systemic manifestations, important eosinophilia and destructive nature of the joint lesions of the hips. The physiopathological mechanisms of ocular and cutaneous manifestations are considered. A dramatic improvement is obtained with tetracyclin.

Adult↗
PubMed1983

[Destructive non-tumoral osteoarthropathies of the shoulder].

Destructive arthropathy of the shoulder is reviewed and the indications of total prothesis are briefly considered. It seems that the long term functional tolerance of destructive arthropathy of the shoulder is better than would be expected considering the radiological damage which is often substantial. The indications of shoulder prosthesis are dominated by rheumatoid polyarthritis and are infrequent in the other forms of these arthropathies.

Arthropathy, Neurogenic↗
PubMed1983

[Plasma exchange in rheumatology. Technical problems, tolerance, indications].

Plasma exchange, used since 1979 in the treatment of severe rheumatoid arthritis, has been the subject of numerous publications in the recent years. According to data from a review of the literature and from our personal experience, this therapy cannot be advocated in the usual forms of rheumatoid arthritis. Because of the side-effects, the complicated technical equipment required and the short duration of therapeutic results, plasma exchange should, for the time being, be restricted to malignant forms of rheumatoid arthritis, polyvisceral exacerbations in lupus and scleroderma, and hyperviscosity syndromes in globulinopathies.

Arthritis, Rheumatoid↗
PubMed1983

[Non-tuberculous abscesses of the psoas. A case of apparently primary abscess of the psoas due to Staphylococcus aureus].

Abscess of the psoas, which is a well recognized complication in tuberculous osteoarticular infections, can also occur in certain regional diseases of the bones or viscera: common germ osteitis, diverticulosis, colic cancer, appendicitis and, above all, Crohn disease. Abscess of the psoas can also present as an apparently primary pyogenic muscular infection. A case is reported of an abscess of the psoas due to Staphylococcus aureus, which occurred spontaneously in an apparently healthy 50-year-old woman, was cured by surgical drainage, and whose course confirmed its primary nature.

Abscess↗
PubMed1982

[Hypophosphoremic osteomalacia of connective tissue tumors].

The authors undertake a general review of the association between hypophosphoraemia and connective tissue tumour, based upon three personal cases and 27 cases of benign connective tissue tumours, as well as cases of hypophosphoraemia related to malignant tumours or to diffuse dysplasia of connective tissue origin, collected from the literature. This syndrome is distinguished from hypophosphoraemia induced by other tumours (myeloma, carcinoma of the prostate) which are based upon different mechanisms. Hypophosphoraemia, associated with a fall in plasma levels of 1-25 (OH)2 D3 by inhibition of renal 1 alpha hydroxylase, suggests the existence of a complex tubular deficit. Removal of the tumour, most often vascular and intra- or para-osseous, results in rapid normalisation of laboratory then radiological and clinical abnormalities. The physiopathology of the syndrome remains very mysterious. It may be likened to certain tubulotoxic syndromes due to cadmium and in particular to maleic acid. However no precise data yet exists regarding any possible abnormal tumour secretion. In practice, any case of hypophosphoraemic osteomalacia requires investigation to locate a possible tumour of connective tissue, and this all the more so when it is accompanied by very low plasma levels of 1-25(OH)2 D2.

Adolescent↗