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A C Leyten

Publications and source records attributed to A C Leyten.

15 recordsLinked to original sources
PubMed1997

Two thrombotic complications in a patient with active ulcerative colitis.

A 30-year-old woman is described with both a cerebral venous thrombosis and a deep vein thrombosis of her leg in association with an exacerbation of her ulcerative colitis. Laboratory investigations revealed a transient functional APC resistance, without Factor V mutation, and a mild hyperhomocysteinaemia. After colectomy the APC ratio was normal. These findings may form a partial explanation of the thrombophilia seen in some patients with active ulcerative colitis.

Adult↗
PubMed1991

Critical illness polyneuromyopathy after artificial respiration.

Up to now, 71 critically ill patients have been reported with neuromuscular complications after artificial respiration. The authors review the literature and present data of a personal series of 22 patients all suffering from severe flaccid tetraparesis and muscle atrophy, which developed after an average of two weeks artificial respiration. The prognosis was relatively good in those surviving the primary disease. The multiconditional causes are discussed with emphasis on the combination of polyneuropathy and myopathy. Tumor necrosis factor (TNF), a key mediator of sepsis, which also has an influence on muscle and nerves, is mentioned as a possible cause of this illness.

Adult↗
PubMed1991

Prognostic significance of conjugate eye deviation in stroke patients.

We prospectively studied the prognostic significance of conjugate eye deviation in 80 patients with acute stroke and compared the 3-month mortality and disability of these patients to those of the Tilburg epidemiological study of stroke. Mortality of patients with conjugate eye deviation was higher (41%) than for the general stroke population (34%), but this difference was not statistically significant (p less than 0.179). Looking at mortality and disability together, we found the outcome of patients with conjugate eye deviation to be significantly worse (p less than 0.001). Deviation of the eyes occurred more frequently to the right (65%) than to the left (35%). In the patient group with eye deviation to the left, mortality was significantly higher (64%, p less than 0.001) than in the group with eye deviation to the right (25%); only two patients of the former group (n = 28) could return home. Compared to the Tilburg epidemiological study of stroke, the group with eye deviation to the left did significantly worse, both for mortality alone (p less than 0.001) and for mortality and disability together (p less than 0.001). The group with eye deviation to the right did significantly worse only for mortality and disability together (p less than 0.01). Our results indicate that conjugate eye deviation is a prognostic factor for poor short-term mortality and disability in stroke patients, especially when the eyes are deviated to the left.

Cerebral Hemorrhage↗
PubMed1990

[Organ donation in a general hospital].

There is an acute shortage of donor organs for transplantation in The Netherlands. It is presumed that many potentially available organs are lost due to insufficient alertness. A retrospective study was made of the results of the procedure for obtaining permission for post-mortem donorship. Records of patients succumbed in the Intensive Care Unit in the period 1983-1987 were checked to ascertain whether these patients had met the current selection criteria for donorship. According to these criteria, 104 of the 531 deceased patients had been suitable. Death had been due to irreversible brain damage in 71 cases, to CVA in 29, to a primary brain tumour in three and to an intoxication in one. The donation procedure was followed in 53 cases of death. In 20 cases relatives refused permission and in 12 there were insuperable practical and technical difficulties. Relatives of 19 deceased patients were not asked for permission for post-mortem donorship. Once the procedure for obtaining permission for post-mortem donorship was implemented according to protocol and on a multidisciplinary basis, the proportion of cases in which requesting permission was omitted fell from 37% to 3%. Greater alertness of those involved to the possibilities of organ donation and good organization result in a growing number of organs available for transplantation, reducing an acute shortage.

Hospitals, General↗
PubMed1983

Multivariate logistic analysis of risk factors for stroke in Tilburg, The Netherlands.

By means of a case-control study conducted between October 1, 1978, and July 31, 1981, in Tilburg, The Netherlands, various characteristics and events, including personal data, health-related behavior, and medical history, were evaluated as risk factors for stroke. The study subjects included 132 stroke patients and 239 age- and sex-matched control patients interviewed at the two city hospitals. To assess joint effects and possible interactions, and to control for multiple confounding factors, a series of multivariate logistic models for matched data were studied. From this analysis, it appeared that hypertension, acute myocardial infarction, cardiac arrhythmias, transient cerebral ischemic attacks, obesity, physical activity during leisure time, education of head of household, and Rhesus factor were all significant stroke risk factors. These risk determinants demonstrated a multiplicative effect in general; however, the influence of some variables on stroke risk was not constant with age (hypertension, acute myocardial infarction, cardiac arrhythmias, obesity, and Rhesus factor) and sex (hypertension and education of head of household). The relationship of diabetes mellitus to stroke slightly decreased and became nonsignificant after adjustment for factors besides age and sex. Stroke risk was not associated with cigarette and alcohol use, family history of stroke and related disorders, marital status, and ABO blood typing.

Adult↗
PubMedDate not supplied

Epidemiology of stroke in Tilburg, The Netherlands. The population-based stroke incidence register: 1. Introduction and preliminary results.

We present the methodology and some preliminary findings of a population-based stroke incidence register operating in Tilburg (about 150,000 persons), The Netherlands. From October 1, 1978 to March 31, 1979, 152 new strokes occurred giving an estimated overall incidence (per 100,000 population) for total and first attacks of 202 and 162, respectively. No major sex difference in stroke risk (all ages) was noted, although males did have a significantly higher incidence at 55--64 years of age. Stroke incidence increased strikingly with age. Thromboembolic infarcts comprised 83% and intracranial hemorrhage 13% of attacks. Males and females differed little in distribution of stroke types. The proportion of cerebral infarction was higher among older than younger cases. The opposite was true regarding intracranial hemorrhage. Embolic infarcts constituted a significantly higher proportion of cases at 65--74 years of age than at other ages. Hemiplegia and speech deficits dominated the clinical picture at onset. The 3-week case fatality for all strokes was 26%. Both a lowering of consciousness (found among 38% of cases during the first 24 hours) and a history of prior stroke were found related to a reduction in survival. Of patients surviving 3 weeks 25% were completely dependent and 25% partially dependent upon others for personal care.

Activities of Daily Living↗
PubMedDate not supplied

An evaluation of risk factors for stroke in a Dutch community.

The objective of the present epidemiological study was to reevaluate the relationship of various suspect risk factors to stroke within a Dutch community. The Tilburg study lends support to findings in other countries concerning the greater stroke risk of persons with high blood pressure, heart disorders, and diabetes mellitus. Significant interactions of both age and a history of myocardial infarction with hypertension on stroke risk were noted. The presence of overweight and possible transient ischemic attacks (TIA) were found related to stroke onset. No increase in stroke risk was associated with cigarette smoking. The extent of leisure time physical activity during one's lifetime was found inversely related to one's chances for stroke.

Adult↗
PubMedDate not supplied

Epidemiology of stroke in Tilburg, the Netherlands. The population-based stroke incidence register: 2. Incidence, initial clinical picture and medical care, and three-week case fatality.

The results of a prospective population study of stroke in Tilburg are reported. The average annual over-all incidence (per 100,000 population) for the period October 1, 1978-September 30, 1980 was 174 for total cases, 145 for first-ever cases. Males and older persons were at greater risk for a stroke. The vast majority of strokes were thrombo-embolic infarctions. Hemiplegia was the predominant neurological deficit resulting from an insult. Patients with speech problems, as opposed to those without, demonstrated more extreme motor deficit when such occurred. Seventy-four per cent of stroke cases had hypertensive blood pressure readings shortly after onset. Most patients were under hospital care during the initial phase of their attacks. The presence of such handling was related to specific patient characteristics. Three-week stroke case fatality was 30% for all patients registered, and varied significantly by age, sex and diagnostic type.

Aged↗