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Biomedical subjects

A C Lucier

Publications and source records attributed to A C Lucier.

11 recordsLinked to original sources
PubMed1989

Flurbiprofen sodium to prevent intraoperative miosis during vitreoretinal surgery.

To assess the efficacy of flurbiprofen sodium 0.03% at maintaining pupillary dilation during vitreoretinal surgery, we performed a randomized, double-masked, controlled trial of 139 consecutive patients. The mean decrease in pupil size during surgery in patients who received flurbiprofen was 0.9 mm; for patients who did not receive the drug it was 0.8 mm. The type of surgery performed (vitrectomy or scleral buckle), gender, age, lens status, and a history of diabetes or previous intraocular surgery were assessed and the addition of flurbiprofen to routine preoperative dilation did not significantly affect the mean change in pupil size for any of these subgroups. Of the nine patients who developed at least 3 mm of miosis, five received flurbiprofen and four did not. Use of flurbiprofen did not appear to reduce intraoperative miosis during vitreoretinal surgery in a clinically meaningful manner.

Adolescent↗
PubMed1988

Pigmentary epitheliopathy, disc edema, and lead intoxication.

A 52-year-old lead-exposed worker presented with disc edema, nerve fiber layer infarcts, and an acute bilateral pigment epitheliopathy that phenotypically resembled APMPPE. The patient had definite laboratory evidence of increased total body lead burden. The simultaneous involvement of retina, disc, and choriocapillaris suggests that what has been reported as the spectrum of APMPPE may represent a nonspecific vascular response to multiple injurious stimuli, including lead.

Edema↗
PubMed1986

Pseudophakic phacoanaphylactic endophthalmitis.

Two cases of pseudophakic phacoanaphylactic endophthalmitis are reported. Both responded favorably to a total posterior capsulectomy performed in addition to removal of the intraocular lens and remaining cortical material. Current theories on phacoanaphylactic endophthalmitis are discussed. Excision of the entire posterior capsule with anterior capsular flaps and entrapped cortex is emphasized as an integral part of the treatment of this condition.

Aged↗
PubMed1985

Identical twins with subretinal neovascularization complicating senile macular degeneration.

This is the first report, to our knowledge, of proliferative macular degeneration developing in the same eye of identical twins. The concept of a familial predisposition in age related macular degeneration is consistent with other known risk factors including race, iris pigmentation, hyperopia and macular drusen which are known to be genetically determined. Monozygotic twins provide ophthalmology with an excellent opportunity to study the hereditary aspects of ocular disease.

Aged↗
PubMed1984

Lipemic diabetic retinopathy.

A study group of eight patients with diabetic retinopathy and marked accumulation of hard exudates in the fundi is described. There was a significant increase in serum triglyceride levels (P less than 0.05) in the study group as compared to a control group of 23 consecutive patients with diabetic retinopathy. This exudative disorder is visually disabling and is associated with legal blindness in 50% of eyes. The authors believe that the term most appropriate to describe such a severe type of exudative response is lipemic diabetic retinopathy.

Adult↗
PubMed1984

Malignant melanoma of the choroid in a husband and wife.

A 52-year-old man was diagnosed as having a large malignant melanoma of the choroid in the right eye. Six years later his 58-year-old wife of almost 40 years was diagnosed as having a large malignant melanoma of the choroid in her left eye. In both patients the diagnosis was confirmed histologically following enucleation. Electron microscopy failed to reveal evidence of viral particles within the tumours. The implications of this unusual occurrence are discussed.

Choroid Neoplasms↗
PubMed1980

Retinal pigment epithelial abnormalities in fundus flavimaculatus: a light and electron microscopic study.

Light, fluorescent, and scanning and transmission electron microscopic examinations of two postmortem eyes from a 24-year-old man with well-documented fundus flavimaculatus with atrophic macular degeneration revealed striking abnormalities in the retinal pigment epithelium (RPE). Beginning near the equator, scanning electron microscopy demonstrated a progressively marked heterogeneity in the size of the RPE cells. Surrounded by a fairly regular mosaic of relatively normal appearing cells, enormously enlarged hypomelanotic cells measuring up to 80 microns in diameter occurred in irregular aggregates that became more prevalent posteriorly. Diffusely and intensely PAS-positive, the RPE was packed with a granular substance with ultrastructural, autofluorescent, and histochemical properties consistent with an abnormal form of lipofuscin. The greatest concentration of lipopigment was noted posteriorly. Stains for acid mucopolysaccharide were only mildly positive. The clinical and fluorescein angiographic manifestations of fundus flavimaculatus are consistent with accumulation of a lipofuscin-like substance in the RPE. The massive amounts of lipopigment encountered in this young individual suggest that disordered lipopigment metabolism may play a major role in the pathogenesis of this retinal pigment epithelial disorder.

Adult↗
PubMedDate not supplied

Retinitis pigmentosa.

Retinitis pigmentosa is a subset of inherited diseases associated with progressive degeneration of the retina otherwise classified as retinal dystrophies. Clinically, patients have nyctalopia (night blindness), progressive visual field loss, and eventually loss of central vision. Patients with retinitis pigmentosa should be evaluated for other ocular conditions that may simulate the condition, as well as for systemic disorders.

Humans↗
PubMedDate not supplied

Round atrophic holes in lattice degeneration--an important cause of phakic retinal detachment.

Round atrophic holes in lattice degeneration are an important cause of phakic retinal detachment. Detachments due solely to round holes in lattice accounted for almost 2.8% of all retinal detachments treated at Wills Eye Hospital from January 1970 to August 1973. These detachments had the following important characteristics: 1. One of the patients were under the age of 30 years. 2. Over 75% of the patients had refractive errors more myopic than -3 D spherical equivalent. 3. Inferior detachments were slightly more common than superior detachments. When located inferiorly, there was a tendency for slow progression as indicated by the frequent presence of pigmented demarcation lines. 4. Surgical repair with standard scleral buckling techniques was successful in 98% of these detachments. Young, moderate to highly myopic patients with round holes in areas of lattice degeneration seem to have a greater risk of developing this type of detachment. Patients with the triad of youth, myopia, and round holes in lattice degeneration deserve close observation.

Adolescent↗