The concept and measurement of bladder work. A review after 6 years.
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Follow-Up Studies↗
Biomedical subjects
A C Poole
Publications and source records attributed to A C Poole.
An improved fully automated continuous-flow system for immunoassays.
A modification to the Southmead continuous-flow automated immunoassay system enables the bound ligand fraction to be quantitated. The bound fraction is sequentially collected, washed, and then eluted from the separating device as a bolus. The misclassification error at separation is of the order of 0.6%, and sample-to-sample interaction is negligible. The application of the modified system to the radioimmunoassay for thyroxine at a rate of 60 samples per hour is described, and satisfactory assay characteristics and performance are documented. The application of the Southmead system to the enzyme immunoassay of thyroxine and to assays for other ligands is discussed.
Humans↗
The concept and measurement of bladder work.
The methodology for the calculation of bladder work from pressure volume traces has been described. Bladder work values have been calculated from the urodynamic data of 50 male patients. When bladder work values were related to the micturition time and the volume passed, a highly significant correlation was demonstrated with urethral resistance. Bladder work values may be a useful index in the diagnosis of bladder outflow obstruction.
Humans↗
Establishing principles for migraine management in primary care.
Published guidelines for the management of migraine in primary care were evaluated by an international advisory board of headache specialists, to establish evidence-based principles of migraine management that could be recommended for international use. Twelve principles of migraine management were identified, covering screening, diagnosis, management and treatments: Almost all headaches are benign/primary and can be managed by all practising clinicians. Use questions/a questionnaire to assess the impact on daily living and everyday activities, for diagnostic screening and to aid management decisions. Share migraine management between the clinician and the patient. Provide individualised care for migraine and encourage patients to manage their migraine. Follow up patients, preferably with migraine calendars or diaries. Regularly re-evaluate the success of therapy using specific outcome measures and monitor the use of acute and prophylactic medications regularly. Adapt migraine management to changes that occur in the illness and its presentation over the years. Provide acute medication to all migraine patients and recommend it is taken at the appropriate time, during the attack. Provide rescue medication/symptomatic treatment for when the initial therapy fails. Offer to prescribe prophylactic medications, as well as lifestyle changes, to patients who have four or more migraine attacks per month or who are resistant to acute medications. Consider concurrent co-morbidities in the choice of appropriate prophylactic medication. Work with the patient to achieve comfort with mutually agreed upon treatment and ensure that it is practical for their lifestyle and headache presentation. Using these principles, practising clinicians can screen and diagnose their headache patients effectively and manage their migraine patients over the long-term natural history of the migraine process. In this way, the majority of migraine patients can be well treated in primary care, ensuring a structured and individualised approach to headache management, and conserving valuable healthcare resources.
Humans↗