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A C Scott

Publications and source records attributed to A C Scott.

105 records · Page 6Linked to original sources
PubMedDate not supplied

Determination of the concentration of explosives in air by isotope dilution analysis.

The concentrations in air of dinitrotoluene (DNT), trinitrotoluene (TNT), nitroglycerin (NG), ethylene glycol dinitrate (EGDN), and pentaerythritol tetranitrate (PETN) were measured at 25 degrees C under equilibrium conditions, and that of cyclomethylene trinitramine (RDX) was measured at elevated temperature by means of an isotope dilution technique. Isotopically multi-labeled compounds were synthesized and used as diluents. Field ionization mass spectrometry was used to measure the abundance ratios of the unlabeled materials. The concentrations in air at 25 degrees C of DNT, TNT, NG, EDGN, PETN, and RDX are 184, 4, 31, 37,000, 7, and 0.8 ppb v/v, respectively. The data obtained may be used for the assessment of the required sensitivity of air-monitoring detection systems.

Air Pollutants↗
PubMedDate not supplied

Electrophoretic typing of glyoxalase I (GLO I) isoenzymes using a mixed starch/agarose gel.

A technique was developed to type the glyoxalase I (GLO I) isoenzymes using a mixed agarose/starch gel. Over six hundred blood samples from Caucasoid people living in separate regions of South Australia were examined and the results compared with other Caucasoid population surveys. Paired blood and semen samples were also tested and the limitations of the technique with regard to blood and semen stains analysis was evaluated.

Australia↗
PubMedDate not supplied

QSAR studies on P-glycoprotein-regulated multidrug resistance and on its reversal by phenothiazines.

Multidrug resistance is brought about largely by membrane transport proteins such as P-glycoprotein (P-gp). We have developed a quantitative structure-activity relationship (QSAR) for P-gp-associated ATPase activity for a diverse set of 22 drugs, and found that such activity is related to substrate molecular size and polarity. We have also developed a QSAR for drug efflux from the blood-brain barrier of another diverse set of 22 drugs, and found that such efflux is a function of drug size and polarisability. Thirdly, we have carried out a QSAR analysis of the ability of 157 phenothiazines and related drugs to reverse multidrug resistance. We were unable to obtain a good QSAR for the whole data-set, but when we divided the data-set into sub-sets of closely related structures, a series of good correlations was obtained, most of which incorporated descriptors that model molecular size and polarity/polarisability. In no instance did we find any evidence that hydrogen bonding or hydrophobicity play a part in multidrug resistance or its reversal, despite that fact that several other workers have reported that these effects appear to be important here.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMedDate not supplied

Adductor transfers in cerebral palsy: long-term results studied by gait analysis.

Thirty-three ambulatory patients with spastic cerebral palsy underwent evaluation and gait analysis an average of 9.6 years after bilateral posterior adductor transfers to the ischium. All patients showed functional improvement postoperatively, which was maintained at long-term follow-up in 94%. Gait analysis, however, documented pelvic obliquity in 85% of this group of patients. Associated with pelvic obliquity was a 36% incidence of unilateral hip subluxation. These complications of posterior adductor transfers have been difficult to treat and have resulted in the abandonment of this procedure at our institution.

Cerebral Palsy↗