Evaluation of oral fenoterol in chronic asthmatic patients.
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Administration, Oral↗
Biomedical subjects
A C Sprenkle
Publications and source records attributed to A C Sprenkle.
Efficacy of dyphylline (dihydroxypropyltheophylline) in exercise-induced bronchospasm.
The efficacy of dyphlline in prevention of exercise-induced bronchospasm (EIB) was studied in seven subjects. A single 15 mg/kg dose of dyphylline 40 minutes prior to exercise prevented EIB as documented by a significantly smaller mean greatest percent decrease in forced expiratory volume in one second when compared to placebo. Mean serum dyphylline concentrations 40 minutes after a dose of 15 mg/kg were probably in the lower portion of the therapeutic range.
Adolescent↗
New drug evaluation using exercise-induced bronchospasm.
Exercise-induced asthma was used to demonstrate that a xanthone, a new orally active cromolyn-like drug, has significant activity in man. The effect of a single oral dose of 8 mg/kg was studied in a double-blind corss-over fashion at two and five hours after administration, with significant inhibition of post-exercise bronchospasm being seen at five hours. Further study seems indicated to determine optimal dosage and clinical effectiveness.
Adult↗