PRELIMINARY OBSERVATIONS ON SPONTANEOUS AND RADIATION-INDUCED LEUKEMIA IN GERMFREE MICE.
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Biomedical subjects
Publications and source records attributed to A C UPTON.
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Granulocytic leukemia, induced in the primary mouse by x-irradiation, was serially transmitted to RF/Up mice. An extra chromosome, as well as a morphologicaly unusual chromosome, was found in the bone marrow cells of all the leukemic mice that had been injected previously either with leukemic spleen cells or with cell-free ultracentrifugates. This suggests that the changes in the chromosomes are caused by a virus.
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