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Biomedical subjects

A C Webster

Publications and source records attributed to A C Webster.

30 records · Page 2Linked to original sources
PubMed1985

Comparison of immune response stimulated in sheep, rabbits and guinea pigs by the administration of multi-component clostridial vaccines.

Over 3 years, the immunogenic responses of various batches of multi-component clostridial vaccines in sheep, rabbits and guinea pigs were compared. Fully susceptible healthy sheep were found to be more suitable than rabbits or guinea pigs for testing the potency of multi-component clostridial vaccines containing Clostridium novyi type B, C. perfringens type D, C. septicum and C. tetani, and recommendations are made that sheep are the preferred species for testing the potency of clostridial vaccines.

Animals↗
PubMed1982

Controlled sedation, sphenopalatine and nasociliary blocks, and bloodless flap suturing in dacryocystorhinostomy.

Recently general anesthesia has become more popular than local for dacryocystorhinostomy, but the increasing bleeding tendency has hindered precise suturing of the nasal and lacrimal flaps. This paper describes a method of achieving controlled sedation with meperidine and chlorpromazine, postural sphenopalatine block with a mixture of cocaine and epinephrine, and nasociliary block with lidocaine. The dry field permits precise suturing of the mucosal flaps and has enabled the authors to gain experience with the miniature aneurysm needle of Reverdin, which facilitates suturing, and with Guibor's canaliculus intubation set, which is especially useful when flap suturing is not possible. Of 20 patients in whom this method was used, 16 obtained relief from dacryocystitis or tearing. Retrobulbar hemorrhage occurred in one patient during induction of the nasociliary block, necessitating cancellation of the operation, and pneumonitis occurred postoperatively in another patient. Respiratory gas exchange was normal when tested. The controlled sedation induced a fall in blood pressure and a rise in heart rate. No adverse effects of any of the drugs were noted. Thus, this method of controlled sedation and regional anesthesia is safe and effective, and because it reduces the bleeding tendency it makes the operation easier and shorter.

Adult↗
PubMed1977

Evolution of emergency cardiac care in Canada.

Acute myocardial infarction is the most common cause of death in Canada. Most deaths occur within the first 2 hours of the onset of symptoms, before the person seeks or is able to obtain medical aid, and are due to arrhythmias rather than massive myocardial damage. Effective electrical and drug treatment of arrhythmias has reduced the hospital mortality but not the community mortality. If mortality from acute myocardial infarction and other causes of sudden unexpected death is to be reduced substantially a major reorganization of emergency medical services is needed so that the benefits of the modern coronary care unit can be provided to the patient as rapidly as possible. Public education in basic life support procedures to sustain life until advanced life support aid arrives is the first step towards the development of a more effective system of emergency cardiac care.

Allied Health Personnel↗
PubMed1976

Field trials with lyophilised herpesvirus of turkeys vaccine against Marek's disease in layer and broiler rearing flocks.

The safety and immunogenicity of commercial lyophilised herpesvirus of turkeys (HVT) vaccine against Marek's disease (MD) was evaluated in 19 field trials involving 76,848 vaccinated and 87,590 control chickens. In the first series of 11 trials involving one commercial vaccine at a dose of 536 plaque forming units (PFU) there was a significant reduction in the incidence of MD (P less than 0.001) and in total mortality (P less than 0.001) from 0 to 18 weeks due to vaccination and the overall protection was 85.2%. In the second series of eight trials involving another commercial vaccine at a dose range of 1360 to 1900 PFU there was a significant reduction in the incidence of MD (P less than 0.001) from 0 to 18 weeks of age due to vaccination. The overall protection was 77.8%. In both series there was a significant difference in MD mortality between meat breeders and crossbred pullets (P less than 0.005) in response to vaccination. There was also a significant difference in total mortality from 0-6 weeks of age between the two series suggesting either differences in response to the two vaccines or differences in the vaccination technique. In a number of trials the incidence of MD was low in the controls, however, where MD incidence was above 2% in the controls protection usually exceeded 80%. It was concluded the vaccines were safe and efficacious and the degree of protection was comparable to that obtained by HVT vaccines described in other countries.

Animals↗
PubMed1975

The adverse effect of environment on the response to distemper vaccination.

Three standard batches of combined distemper and hepatitis vaccine tested in pups housed indoors during a constantly hot summer failed to elicit antibody to distemper virus or to protect the pups against challenge with virulent virus. The response to hepatitis vaccination was normal. When tested in pups housed outdoors, the same batches of vaccine produced antibodies to distemper and protection against the disease. It appears that high relative humidity combined with high environmental temperature caused an increase in body temperature of the pups which was deleterious to the distemper vaccine but did not affect the more heat resistant hepatitis vaccine.

Animals↗