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Biomedical subjects

A C de Groot

Publications and source records attributed to A C de Groot.

At least 55 records · Page 3Linked to original sources
PubMed1990

[Contact allergy for Alstrumeria (inca lily)].

We report 6 patients with occupational contact allergy to Alstroemeria cultivars. Four of them presented with the clinical picture of 'tulip fingers'. They all reacted to parts of fresh plants and to tuliposide A. The literature on Alstroemeria allergy is reviewed.

Adolescent↗
PubMed1990

[Inefficacy of oral contraception during use of minocycline].

A healthy woman aged 21 years who used the oral contraceptive Trigynon became pregnant while being treated with Minocin (minocycline; 100 mg per day) for acne conglobata. While the risk of use of antibiotics such as this one reducing the efficacy of oral contraceptives is small, patients should nevertheless be informed that the risk exists.

Acne Vulgaris↗
PubMed1990

Contact allergy to furazolidone.

A case of occupational contact allergy to furazolidone, used as an animal feed additive and as an antimicrobial drug in veterinary medicine, is described. The patient did not react to furazolidone 2% pet. Using PEG-400 and alcohol as patch test vehicles resulted in positive patch test reactions. No cross-reactions were observed to other nitrofuran derivatives (nitrofurazone, nitrofurantoin) or to furfural. The literature on contact allergy to nitrofurans is reviewed.

Adult↗
PubMed1990

The frequency of contact allergy in atopic patients with dermatitis.

A prospective study was performed to establish the frequency of contact allergy in atopic patients presenting with dermatitis, compared with non-atopics suffering from dermatitis. During 1987-1988, all new patients aged 15 years or older, who consulted us for dermatitis, were investigated. They were patch tested with the European standard series, methyl(chloro)isothiazolinone and other relevant allergens. In addition, they were prick tested with 24 inhalant and 11 food allergens. Patients having at least 2 positive prick tests, and patients with 1 positive prick test and a (family) history of atopic diseases were defined as atopics, as were those who presented with classic atopic dermatitis but with negative prick tests. 499 patients were evaluated: 159 men and 340 women. 214 patients (43%) were atopic, the other 285 (57%) were non-atopic. In the atopic group, 79 persons (37%) had at least 1 positive patch test reaction. In the group of non-atopics, 149 patients (52%) had contact allergies. The difference is statistically significant (chi 2; p less than 0.05). It is concluded that adult atopics seen in dermatological practice who present with dermatitis are less frequently contact sensitized than such patients who are non-atopic. Nevertheless, a yield of nearly 40% positive patch test reactions in this group still makes routine patch testing necessary.

Adolescent↗
PubMed1989

Isothiazolinone preservative: cause of a continuing epidemic of cosmetic dermatitis.

A preservative system for cosmetics and toiletries containing as active ingredients a mixture of methylisothiazolinone and methylchloroisothiazolinone (1.5%) is an important cause of cosmetic allergy in many European countries. Most cases have been caused by products of the "leave-on" variety, such as moisturising creams. The use of isothiazolinone preservative in such products should be abandoned. More critical evaluation of its sensitising potential before marketing might have prevented the continuing epidemic of allergic cosmetic dermatitis due to this preservative. New chemicals should undergo extensive toxicological evaluation before their use in cosmetics is allowed. Ingredient labelling should be made a legal requirement.

Cosmetics↗