PubMed Health⌕ Search

Biomedical subjects

A C de Groot

Publications and source records attributed to A C de Groot.

108 records · Page 6Linked to original sources
PubMed1985

Kathon CG: cosmetic allergy and patch test sensitization.

Three cases of contact allergy to Kathon CG, a preservative for cosmetics and toiletries containing, as active ingredients, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one are presented. In two patients, Kathon CG was contained in a moisturizing cream, and the third was sensitized by a diagnostic patch test. Although it has been used extensively in cosmetics and toiletries for 9 years in Europe and 4 years in the USA, these appear to be the first case reports of non-occupational sensitization to Kathon CG.

Adult↗
PubMed1985

Patch tests with fragrance materials and preservatives.

179 patients suspected of cosmetic allergy were patch tested with a series of 16 fragrance materials and 9 preservatives. In 67 patients (37.4%), 1 or more of these substances gave positive reactions. In the group of fragrance materials, the largest numbers of positive patch test reactions were seen to isoeugenol, oak moss, geraniol, alpha-amylcinnamic alcohol, and a mixture of alpha-amylcinnamic aldehyde and alpha-hexylcinnamic aldehyde. The fragrance mix in the ICDRG standard series detected nearly 80% of cases of contact allergy to fragrance materials other than its constituents. In the group of preservatives, Kathon CG and quaternium-15 scored the highest number of positive reactions. It is argued that the commonly used patch test concentrations of 2% for oak moss and geraniol may be too low to detect all cases of sensitization.

Cosmetics↗
PubMed1981

Contact allergy to dithranol.

During treatment with a dithranol-containing collodion for common warts, a patient developed a eczematous reaction on the treated sites and the extremities. Patch testing revealed a contact allergy to dithranol. Two applications of the collodion cured the warts within 3 weeks. It is argued that contact allergy to dithranol occurs more frequently than is suspected.

Adult↗
PubMed1977

Some effects of injected hyoscine butylbromide: a versatile class experiment in human pharmacology.

1 An experiment with hyoscine butylbromide has been used to demonstrate how drug effects differ in intensity and time course after intravenous (20 mg) and subcutaneous (40 mg) injection with and without massage of the injection site. It also demonstrates how objective and subjective observations may be related, and gives students practice in the interpretation of experimental data. 2 The experiment takes about 2 h, and the effects of the drug have worn off completely after about 3 hours. 3 The structure of the discussion of the experiment and its results with the students are described to draw attention to the questions that can be asked of the data. The results obtained with 41 subjects are summarized to illustrate this discussion. 4 Various ways of modifying the experiment to suit other teaching objectives are mentioned. The need to consult the local Ethics Committee before undertaking experiments on students is emphasized.

Butylscopolammonium Bromide↗
PubMedDate not supplied

Oleamidopropyl dimethylamine.

The cationic emulsifier oleamidopropyl dimethylamine has been responsible for many cases of cosmetic sensitisation in The Netherlands. Of 119 patients with proven cosmetic-related allergic contact dermatitis, 13 (11%) were allergic to oleamidopropyl dimethylamine. The clinical data of 12 patients, all sensitised by one particular baby body lotion containing 0.3% of the emulsifier, are presented. The cross-reaction pattern of oleamidopropyl dimethylamine was investigated by patch testing 13 patients allergic to the emulsifier with a series of related amideamine type emulsifiers. Most cross-reactions were observed to ricinoleamidopropyl dimethylamine lactate and tallowamidopropyl dimethylamine (11 patients, 85%). 9 patients (of 12 tested: 75%) reacted to lauramidopropyl dimethylamine and 6 (46%) to myristamidopropyl dimethylamine. It is concluded that the presence of oleamidopropyl dimethylamine in a concentration of 0.3% in stay-on cosmetics, especially when applied to damaged skin and/or the periorbital area, bears a definite risk of the induction and elicitation of contact allergic reactions.

Cosmetics↗
PubMedDate not supplied

Isothiazolinone preservative as important contact allergen in cosmetics.

Kathon CG (K-CG) containing as active ingredients 2-methyl-4-isothiazolin-3-one and its 5-chloro analogue, is a very effective and widely used preservative system for cosmetics and toiletries. Of 243 patients routinely patch tested because of suspected contact dermatitis 8 (3.3%) reacted to K-CG 100 ppm in water. All but 1 patient allergic to the preservative used cosmetics of 2 brands very widely distributed in the Netherlands, both containing K-CG. The observed positive patch test reactions were shown to be relevant in all these cases. Repeated open application tests were positive in 3/5 of the patients tested. The pertinent literature is reviewed. It is concluded that contact allergy to K-CG is common. Sensitization usually occurs from creams and lotions applied to damaged skin (irritant dermatitis, atopic dermatitis), but some patients become sensitized by cosmetic products used on healthy skin, especially on the face and around the eyes. The risk of induction and/or elicitation of contact dermatitis from the use of rinse-off products such as soap, shampoo and shower foam is small.

Adolescent↗