False-negative result in a microparticle enzyme immunoassay (MEIA) for the detection of antibodies to human immunodeficiency (HIV)
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Biomedical subjects
Publications and source records attributed to A Cabarcos.
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A case report of pulmonary carcinosarcoma and a review of the literature is presented. This is the only case where diagnosis has been obtained by thin needle percutaneous biopsy.
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Authors, based on objectives data of large incidence of acute Brucellosis in their job area in the last years, get in every patient coming in their Medicine Internal Department suffering from it through three years. They analyse mainly the epidemiological, clinic-biological and therapeutics aspects of this acute pathology. The epidemiological conclusions established on the objective analysis of the series issue make known great interest. The increase of this illness does not happen to be because of infection in animal farms, but for the existence of food channels that are not under sanitary control.
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The immunocellular response to fetal antigens was studied in ten patients with hepatocarcinomas. Homogenized extracts of human fetal liver and purified human alpha-fetoprotein were used as antigen substances. The control group included 15 patients with cirrhosis of the liver. The level of circulating T lymphocytes (E-rosettes) was also registered. Patients with hepatocarcinoma showed a definite response to both antigens, determined by the degree of inhibition of leukocyte migration. The migration indices were as follows: x = 0.65 +/- 0.16 for homogenized fetal liver antigen, and x = 0.79 +/- 0.13 for alpha-fetoprotein antigen. These values were 0.93 +/- 0.13 and 0.95 +/- 0.15 respectively in the cirrhotic patients. The differences in the migration indices for the two groups were statistically significant with both antigens (p less than 0.0005 and p less than 0.005). The decrease of the number of T lymphocytes in patients with hepatomas was also significant (p less than 0.005). The determination with homogenized fetal antigen was more sensitive than with alpha-fetoprotein (p less than 0.01). A significant relationship between the severity of the tumor and the immunocellular response could also be seen (r = 0.84; p less than 0.001). Response tended to diminish as the tumor progressed. The disappearance of immunocellular response seemed to depend at least in part on the decreasing number of T lymphocytes, since there was a significant inverse correlation between the two parameters (r = -0.75; p less than 0.01).
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