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A Calavrezos

Publications and source records attributed to A Calavrezos.

24 records · Page 2Linked to original sources
PubMed1981

[Stage IIIB and IVB Hodgkin's disease. Response to chemotherapy, relapses, survival rates (author's transl)].

Thirty-two of 71 (45%) stage IIIB and IVB patients up to the age of 60 achieved a complete remission (CR) by initial COPP-chemotherapy. Twelve additional cases were free of symptoms after COPP, but showed persistent disease at postprimary laparotomy or within 3 months after cessation of chemotherapy. Forty-four per cent (n = 17) of this initial COPP failures could also be brought to CR by ABVD-chemotherapy or/and radiotherapy within 7 to 51 months. Cases with lymphocytic depletion reached CR in only 31% (N = 5/16) in comparison to 80% (n = 44/55) of the three other histological subtypes. Without additional consolidation therapy 60% relapsed, but only 11% after adjuvant total-nodal irradiation. An increase of side effects after therapy has not been observed so far. Patients with once attained CR have a survival probability of 93% after nearly 8 years from diagnosis. For the whole stage IIIB/IVB group the values were 85% up to the age of 30 (n = 28) and 60% for the age group of 31-60 (N = 43). They were clearly higher than in the 1966-1971 patients who showed values o 39% nd 41%, respectively. Beyond the stage of 60 (n = 15) the survival probability of 10% after 3 years in comparison to former 15% revealed no improvement.

Adolescent↗
PubMed1981

[Survival rates in Hodgkin's disease in relation to histological subtypes (author's transl)].

Due to advantages of diagnostic and therapeutic progress the five-year-survival rates for 3 histological subtypes have become comparable in 322 patients with Hodgkin's disease during the years 1972 to 1979. Five-year-survival was 96% for the predominantly lymphocytic type, 90% for the nodular sclerosing type and 77% for the mixed cell type. Survival for all types together was 84% after 5 years and 80% after 7 years. The lymphocytic depletion type had a much worse prognosis with a five-year-survival of 31%. Apart from a reduced incidence of nodular sclerosis after the 40th year of life the histological forms were evenly spread between age groups and sexes On the other hand there were relationships between histological type and clinical stage.

Adult↗
PubMed1981

[Survival rates and reduction or mortality in Hodgkin's disease in relation to age of the patient (author's transl)].

Survival rates were calculated in 550 patients with Hodgkin's disease during the years 1966 to 1979 according to decade of age and were classified into three significantly different groups. The patients have been investigated according to a standard procedure since 1972 and the major part was treated intensively. The five-year-survival rate was 95% for the group under 30 years of age, 75% for the group between 31 and 60 years and 47% for the older group. For the three comparative groups during 1966 to 1971 the rates of 76%, 60% and 40% were markedly lower. Mortality in the young and middle age groups has decreased in Hamburg since 1975. Due to the continued above average death rate after the 60th year of life this development is not sufficiently noticeable in the total group. A similar tendency is shown in the GFR mortality statistics. With increased use of diagnostic and therapeutic possibilities the age of the patient becoming one of the most important prognostic features in Hodgkin's disease.

Adult↗