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Biomedical subjects

A Calcagno

Publications and source records attributed to A Calcagno.

26 records · Page 2Linked to original sources
PubMed1982

[Ca++ dependence of the contraction of coronary artery segments in response to norepinephrine after beta-adrenergic blockade].

The effect of external calcium concentration on the NE-induced contraction after beta-adrenergic blocking was studied in vitro. It resulted that the effect of NE was enhanced by increase, or reduced by decrease of calcium concentration. NE-induced contraction was not abolished when the bathing fluid was Ca++-free. The disappearance of the NE effect was only obtained in preparations treated with EDTA and perfused with Ca++-free Ringer-Locke solution. It is concluded that NE induced contraction after beta-adrenergic blocking is Ca++-dependent and on the tissue bound Ca++.

Animals↗
PubMed1981

[Comparison of quandrantectomy and Halsted's radial mastectomy. Personal cases].

The authors review all the breast diseases and tumours observed from 1972 through 1979 at the Division of Surgery, Hospital of Rapallo. On the basis of personal experience they discuss the possibility that, in the treatment of early breast cancer, a relatively conservative surgery (i.e. quadrantectomy), followed by postoperative radiotherapy and adjuvant chemotherapy in the N+ cases, give no worse results than standard radical mastectomy, in preventing local relapses and distant metastases, and therefore in conditioning both free-of-disease interval and survival of the patients, as many Authors in these last years have well shown either for quadrantectomy or other conservative procedures. This retrospective study particularly evaluates the results of 12 quadrantectomies performed in Stage I and II, compared to 8 Halsted radical mastectomies in the same Stages: all patients in the two groups survive free of disease (follow-up for the quadrantectomies from 6 to 41 months). Furthermore 4 cases of Stage III breast cancer are presented, 2 treated with Halsted procedure: in the first case the death occurred at 19 months, after the development of distant metastases, while in the second local relapses have been observed at 11 and 30 months; 2 patients were treated with quadrantectomy, as they didn't accepted a radical procedure: both survive free of disease at 17 and 23 months respectively.

Adenocarcinoma↗
PubMed1981

[Effect of prostaglandin-synthetase inhibitors on responses of segments of coronary arteries to 4-methylesculetol and/or to angiotensin II].

The aim of this work is to study the mechanism by which 4-methylesculetin (4-Me) causes the relaxation or inhibits the angiotensin-2 (ATN2) induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with ascorbic acid, on basal tone and ATN2 induced contraction of isolated coronary strips have been studied. Experiments have been carried out in the presence of lysine acetylsalicylate (LAS) and indomethacin (IN), specific inhibitors of prostaglandin-synthetase. Both LAS and IN decreased, but did not abolish, the 4-Me induced relaxation and suppressed the depressive effect of 4-Me on the ATN2 dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release in the smooth muscle.

Angiotensin II↗
PubMed1981

[Influence of 4-methylesculetol on the response of segments of isolated coronary arteries to adrenaline, in presence of pyrogallol].

The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition. In order to test this hypothesis, we studied the influence of 4-methylesculetin (4-Me), alone or associated with ascorbic acid, on the response of isolated coronary strips to AD, in the presence of pyrogallol. Both 4-Me being enhanced by the addition of ascorbic acid. The effects were reduced or abolished in the presence off pyrogallol, a well known COMT inhibitor. It is concluded that 4-Me inhibits COMT, as other bioflavonoids.

Animals↗