Biomedical subjects
Publications and source records attributed to A Cambiaso.
Silicon-based H(+)-sensitive biosensors in proximity to a cell population detect variations in cell metabolism via local measurements of changes in pH. The feasibility of this approach is shown in the case of ISFET devices.
Traditional X-ray technique have proved be scarcely reliable in determining bone tissue mineral status especially when comparing X-rays made at different times. The use of ergal or hydroxylapatite samples has been put forward to resolve this problem since, when used together with computerised imaging techniques, they allow a more precise and quantitative analysis to be made. The velidity of tyhis technique is confirmed by an experimental trial on animal bone.
The adhesion and growth of cells on silicon dioxide substrata are analysed. The adhesion of human red blood cells to silicon dioxide layers of different depth and doping compares well with that to glass. Rat pheochromocytoma cells also grow on the same substrata. The adhesion of these two biological systems is characterized at the microscopic level by using the quite new technique of scanning reflection acoustic microscopy. Possible future developments towards the functional coupling of living cells to microelectronic integrated circuits are briefly discussed.