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A Cappellani

Publications and source records attributed to A Cappellani.

18 recordsLinked to original sources
PubMed2006

Thyroid transcription factor 1 (TTF-1) and p63 expression in two primary thyroid papillary carcinomas of branchial cleft cysts.

Malignant lateral cervical cysts can be related to metastatic tumors or rarely to primary thyroid carcinoma arising in branchial cleft cysts. This study evaluates the expression of thyroid-associated transcription factor-1 (TTF-1) and p63 in three branchial cleft cysts and in two primary thyroid papillary carcinoma of branchial cleft cysts. TTF-1 was negative in the nuclei of the lining epithelia of branchial cleft cysts, but positive in the adjacent normal thyroid tissue, while TTF-1 was positive in the nuclei of the lining epithelia and in the nuclei of the papillae and follicles in branchial cleft cysts with ectopic thyroid carcinoma. P63 was positive in the nuclei of the lining epithelia of branchial cleft cysts, but negative in the adjacent normal thyroid tissue. Papillary thyroid carcinoma of branchial cleft cysts displayed p63-positive foci. In conclusion, our results demonstrate that TTF-1 cannot distinguish between primary and metastatic tumors of branchial cleft cysts. The detection of p63 in papillary thyroid carcinomas of branchial cleft cysts could suggest that p63 contributes to the onset of this tumor. It is really important to evaluate if the case has a metastatic derivation or represents papillary thyroid carcinoma arising in ectopic thyroid tissue in a branchial cleft cyst.

Adenocarcinoma, Papillary↗
PubMed1983

Superoxide dismutase activities in Yoshida ascites tumor cells.

Cu-Zn and Mn superoxide dismutase (SOD) activities in Yoshida ascites tumor cells and in the liver of ascitic rats were assayed. The cytosolic and soluble mitochondrial fractions were used for assay of Cu-Zn SOD and Mn SOD respectively. The specific activities of Cu-Zn SOD as well as Mn SOD were found diminished in Yoshida ascites tumor cells and in the liver of ascitic rats when compared to normal rat liver.

Animals↗
PubMed1979

[Complications of idiopathic chronic colitis].

The Authors reviews the acute and chronic complications of chronic idiopathic colitis in a series of 112 cases of his own observation. He discusses perforation, toxic megacolon and massive hemorrhage in terms of their pathogenesis, diagnostic procedures and incidence in the course of ulcerative colorectitis (Crohn's disease). He deals to some length with surgical indications and the choice of operation, both being the subject of considerable controversy, and he outlines his own views in the matter. Among chronic local complications he lists benign stenosis, pseudopolyposis, and fistulization; all of which, unlike neoplastic complications, seldom require surgery.

Abscess↗
PubMedDate not supplied

Cystic dilatation of common bile duct. Case report and review.

The cystic dilatation of the common bile duct is a rare disease in Europe and in the USA; even rarer in adults. In fact less than 30% of cases are described in the over 20's. There are some reports in the elderly. When observed in adults the diagnosis is usually due to the onset of symptoms of associated pathologies or to complications such as cholangitis or cancer. Ultrasound, CT and ERCP allow, in the majority of cases, an adequate pre-operative characterization of the lesion. Intra-operative cholangiography verifies the completeness of surgery--always resective--and excludes residual biliary pathologies. The treatment in patients who already underwent conservative surgery is more complex, in fact, in symptomatic patients a second observation and resection is mandatory while in asymptomatic patients a careful and complete follow-up is adequate without underestimating the cancer risk. Septic and inflammatory complications, especially if chronic or recurring, can damage the liver; here resection or liver transplantation can be necessary. The case here reported is a 24-year-old woman with recurring cholangitis for at least 2 years in which US, CT and ERCP showed a Todani's type I cystic dilatation of the CBD. The total excision of the cyst with hepatic-jejunal anastomosis was carried out. A two-year follow up demonstrated no symptoms and normal laboratory findings; cholangioscintigraphy showed a good hepatic-biliary and anastomotic function.

Adult↗
PubMedDate not supplied

Spontaneous rupture of a giant hemangioma of the liver.

Hemangiomas are frequent benign tumors of the liver. Symptoms (abdominal pain and fullness) are mostly seen in giant lesions. Rupture is the most severe complication, can occur spontaneously, with intraperitoneal bleeding, in 1-4% of hemangiomas and has been described in about 30 cases in the international literature with a high mortality (about 60%). This complication is the principal indication for surgery. Although spiral CAT scan and MR are actually the most efficacious imaging methods for study of liver hemangiomas, after Echography, emergency techniques that allows a simultaneous therapeutic approach--as is angiography--are preferable. Trans-arterial embolization (TAE) is in fact useful to stop bleeding and then to perform a safer surgery. A successful embolization can delay the surgical resection of the hemangioma for the time necessary to recover from the hemodynamic distress. Aside from the success of angiographic approach, surgery remains mandatory, effective in stopping the bleeding and in preventing re-bleeding or other complications of TAE such as abscess, fever, etc.. Intraoperative echography currently is the best method to identify vasculo- biliary anatomy and to perform a correct resection. The absence of risk factors for spontaneous rupture of liver hemangiomas, makes this event unpredictable. The best treatment for non-ruptured hemangiomas is still controversial but surgery is usually limited to symptomatic tumors larger than 10 cm.

Adult↗
PubMedDate not supplied

Ductal carcinoma in situ (DCIS) of the breast: thirty-two consecutive cases under 50 yrs detected by mammography: treatment and results.

Thirty-two consecutive cases of ductal carcinoma in situ of the breast in women under fifty are presented. Diagnostic procedure, pathological aspects, treatment and outcome are reported. All the patients had their cancer diagnosed by mammography. The tumor was marked by stereotactic or ultrasound guided localization. Lumpectomy without axillary node dissection was the surgical treatment of thirty lesions with good cosmetic results; radiation therapy was advised in all of these cases. In two cases mastectomy with immediate reconstruction was performed because of the multifocality of the cancer, none of the patients experienced local or distant recurrence. This experience emphasizes the importance of mammographic screening for women 40 years of age, in fact this approach allowed the diagnosis of a large number of DCIS. A correct definition of the problem and a multidisciplinary therapeutical approach is warranted to prevent the high local recurrence rate reported in the past.

Adult↗
PubMedDate not supplied

Laparoscopic repair vs open surgery for incisional hernias: a comparison study.

BACKGROUND: Incisional Hernias complicate 2-11% of laparotomies and the primary closure of the defect is followed by recurrence in 20-46% of patients. In spite of introduction of prosthetic materials and new techniques the rate of failure reduced but a gold standard has not been defined. Laparoscopic approach, recently introduced appears promisingly effective but only few and small series have been published. MATERIALS AND METHODS: Two series of patient, 11 treated by laparoscopic repair (LR) and 15 undergone to open prosthetic repair (OR) are compared with regard to age, sex, previous surgery, number of fascial defects, size and location of hernias, ASA status, operating time, intra and postoperative complications, length of hospital stay, follow up evaluation and hernia recurrence. Prosthetic materials were e-PTFE in LR group and e PTFE or Polypropilene in OR group. Peripherical hernias have been excluded from the study. RESULTS: In LR group has been observed a longer mean operative time and a shorter hospital stay than in OR group. No intraoperative complication was observed in LR and 1 in OR group. Early and late complications were more frequent in OR than in LR group but the removal of prosthesis was not needed in any case. Mean follow up is 40 months for OR and 18 for LR group with no recurrences in both groups. CONCLUSIONS: Laparoscopic repair of incisional hernias appears in our experience as good as open prosthetic repair, with all generic vantages related with mini-invasive approach and the specific one of lesser manipulation of prosthesis and fewer infective complications.

Aged↗
PubMedDate not supplied

Nonparasitic cysts of the liver: laparoscopic treatment and long-term results.

BACKGROUND: In the current debate on the indications for the laparoscopic treatment of symptomatic simple hepatic cysts, we emphasize the importance of the exact indications, practicing in an area endemic for hepatic hydatidosis. 8 years ago we started treating laparoscopically the simple hepatic cysts and the polycystosis. Although the laparoscopic approach to parasitic hepatic cysts has been recently introduced, this method has to be the result of a conscious choice and with a presumptive diagnosis to support it. In fact, reviewing the literature on the subject, we realized how most of the intraoperative complications were due to an erroneous preoperative diagnosis, likely to be attributed to the infrequent observation of hepatic hydatid disease. Hence, it seems of primary importance to review the subject in light of the potential dangerous aspect of the laparoscopic approach. METHODS: From 1992 to 2000 we treated 38 cases of benign liver cystic disease (29 echinococcal cysts, 8 symptomatic simple cysts, 1 polycystosis). Due to the endemic nature of the disease in our territory, the preoperative diagnosis was very meticulous (ultrasonography, CT scan, MRI, serology...). Only 9 cases with a preoperative diagnosis of simple cyst or polycystosis were treated with laparoscopic wide fenestration, combined with cholecystectomy in three cases. The follow-up consisted of ultrasonography in the majority of cases and CT scan in 2. RESULTS: All the 9 laparoscopic cases were uncomplicated and no conversions to open procedures have been recorded. The final pathology confirmed the initial diagnosis in all cases. The follow-up ranged between 1 and 8 years and complete remission has been obtained. CONCLUSIONS: The results of this study demonstrate how a meticulous preoperative clinical evaluation can avoid intraoperative complications, making the laparoscopic approach to non-hydatid hepatic cystic disease safe and efficacious. Although laparoscopy is indicated in parasitic liver pathology, the technical approach is very different from the simple cystic disease. In the former, in fact, hepatic resection or pericystectomy are utilized, the results of which have been currently evaluated and compared with the open technique on a large scale on several ongoing trials.

Adult↗
PubMedDate not supplied

[Prolassomucosectomy according to Longo. Intermediate results].

We present results obtained in our first series of 25 patient treated by prolassomucosectomy for haemorrhoidal prolapse with a follow up of 18-36 months. Control of the disease and functional results proved to be optimal. After small early haemorrhages from the suture line, we started adding stitch sutures with haemostatic intent to all three vascular pedicles. Early or late additional complication were not observed.

Adult↗
PubMedDate not supplied

A pure primary squamous cell breast carcinoma presenting as a breast abscess: case report and review of literature.

We report the fourth worldwide case of pure primary squamous cell carcinoma of the breast presenting as an abscess. An inflammatory breast lesion in postmenopausal woman must be suspected as a malignant one and drainage of the abscess has to be followed by an accurate excision. The finding of a pure squamous cell carcinoma bears the necessity of an accurate diagnostic work up, to exclude a skin lesion or a metastasis from other district. Also histological criteria are discussed. More difficult to outline therapeutic options, due to the rarity of disease and great difference in outcome observed.

Abscess↗
PubMedDate not supplied

A case of branchial cyst with an ectopic thyroid papillary carcinoma.

We report the fifth case worldwide described of thyroid papillary carcinoma arising in a branchial cyst. A metastatic lesion from occult primary thyroid carcinoma has to be ruled out. The embryology of this cervical lesion is also discussed in order to point out the diagnostic criteria and the therapeutic guidelines.

Adult↗
PubMedDate not supplied

Adult intestinal intussusception: a case report of a rare clinical entity.

Intussusception in adult is a rare entity that challenges the surgeon opening a wide range of issues in order to define the etiology and therapeutic strategy. Whether to resect or not the bowel is the main question. The answer can be given only after having seen the site of obstruction and the etiology. Colonic intussusception is best treated by resection. Also small bowel intussusception can require resection if a neoplasm is the cause. Peutz Jeghers can be one of these causes as is seen in the case we report.

Age Factors↗
PubMedDate not supplied

[Does there exist a current indication for myotomy in diverticular disease of the colon?].

Thanks to advances of gastroenterological and dietary regimen of patient with more complicated diverticular disease of the colon, the surgical indications to myotomy are nowadays very low, if not more at all. The insurgence of complications is naturally a precise indication to demolitive surgery actually with low postoperative morbidity and mortality.

Adult↗