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Biomedical subjects

A Cardone

Publications and source records attributed to A Cardone.

At least 55 records · Page 3Linked to original sources
PubMed1994

Therapeutic prospects of natural alpha interferon from normal human leucocytes in the treatment of genital condylomata in HIV positive women.

Various Authors underline that HIV positive women have a higher CIN incidence and a higher prevalence of HPV. HIV could act as cofactor in the proliferation of HPV manifestation, because of a hypothetical deficit of local immunity. 5 HIV positive patients have been examined: 3 of them presenting vulvocondylomas and/or VIN were treated with 1.000.000 IU alpha IFNn three times a week for three weeks. 2 of them presenting CIN and/or HPV were treated with a two-phase therapy: A) Induction therapy: 3.000.000 IU 3 times a week for three cycles. B) Maintenance therapy: 1.000.000 IU 3 times a week for three months. IFN was the primary treatment for viral lesions, even though an improvement of prognostic indices (CD4, CD4/CDB, 2M), has shown its usefulness in association or in alternative to AZT.

Adolescent↗
PubMed1994

[Cystic hygroma: 2 case reports and review of the literature].

Cystic hygroma, an infrequent malformation of the lymphatic system (5 cases per 1000 abortions with CRL greater than 3 cm), was observed in 2 cases which prompted the present study. The Authors also present a brief review of the literature on this topic. After reviewing the hypothetic pathogenesis of the lymphatic obstruction which underlines this pathology, the paper focuses on the association of hygroma and anatomical and chromosomic alterations. The various anatomopathological and echographical findings are then described. Special attention is drawn to the diagnosis of cystic hygroma, after which the two case studies are illustrated. The prognosis of this pathology is pessimistic and the patient and specialist have to choose between immediate abortion or waiting for the inevitable outcome of gestation.

Adult↗
PubMed1993

Intraperitoneal (ip) cisplatin-mitoxantrone-interferon-alpha 2b in ovarian cancer patients with minimal residual disease.

Forty-one ovarian cancer patients with less than 2 cm residual disease after systemic cisplatin-based chemotherapy received 4 courses of an ip regimen including cisplatin (75 mg/m2), mitoxantrone (20 mg/m2), and interferon-alpha 2b (30 mil IU/m2). The most important side effects were abdominal pain and fatigue. Overall 15/41 patients (37%) required narcotic analgesia for severe abdominal pain. In 1 case laparotomy was necessary due to bowel obstruction. Grade 3-4 myelotoxicity was observed in 18/41 patients (28 courses). No treatment-related death occurred. Pathological complete response (pCR) was achieved in 23/37 (62%) evaluable patients. Four-year disease-free survival was 50%, and no relapse occurred after 32 months. The estimated 4-year progression-free survival (PFS) and overall survival were 35 and 60%, respectively. Patients who achieved pCR showed significantly better survival than the others (P < 0.000). At multivariate Cox's analysis pCR achievement was the most important predictor of PFS (P < 0.005) and survival (P < 0.02). Age (< or = 60 vs > 60) and CA-125 serum levels at entry (normal vs increased) also showed independent predictive value. On the basis of multivariate analysis results we created a risk model for survival and PFS based on age and CA-125 at entry. We identified three subgroups of patients with significantly different outcomes. With this new ip combination long-term disease-free survival is achieved in a significant part of ovarian cancer patients with small tumor burden. A longer follow-up is needed to see whether it can cure some of these patients, and further comparisons with other ip or systemic regimens are needed to draw definitive conclusions about its role in these patients.

Adult↗
PubMed1992

Malpractice in obstetrics: a contribution of cases in southern Italy.

Looking ahead to the abolition of many intra-European frontiers the Authors offer this contribution to the discussion of the medico-legal aspects of gynecological activity in the United Europe of 1993. It is to this end that they present the data from a review of the material which has been the subject of litigation on the part specialists in Southern Italy, also commenting on the case series in the light of the Italian provisions in force up to date.

Abortion, Induced↗
PubMed1992

[Thr role of histiocytes in the cytodiagnosis of endometrial adenocarcinoma].

The Authors point out the importance of histiocytes in Papanicolaou smears. Histiocytes are associated with endometrial carcinoma on tissue sections and may be seen on cervicovaginal smears as well. Smears obtained from 120 women, with clinical signs of endometrial diseases, were evaluated to determine the correlation between the presence of histiocytes in the cervicovaginal smears and endometrial adenocarcinoma. Histiocytes were quantified as minimal [less than 5 per high-power field (hpf)], moderate (5-10 hpf) or heavy (greater than 10/hpf). The histiocytes were found in smears from 80 women. Five adenocarcinomas, 9 hyperplasias were detected in 20 patients with moderate or heavy smears. The Authors conclude that the presence of histiocytes among postmenopausal women who have cervicovaginal smears should not be ignored. The data indicate that, in the absence of endometrial cells, histiocytes on cervicovaginal smears of postmenopausal women are associated with more elevated relative risk for endometrial carcinoma.

Adenocarcinoma↗
PubMed1992

[Therapeutic plans for the treatment of HPV infections by systemic administration of interferon-alpha. Experience with preneoplastic pathology of the uterine cervix associated with viral cytopathic effects].

The principal action of IFN is anti-viral, rather than antiproliferative and immunomodulatory. All three actions are required to resolve pre-neoplastic uterine cervix pathologies, above all if they are at an early stage or associated with viral cytopathic effects.

Adjuvants, Immunologic↗
PubMed1992

[Association between inguinal endometriosis and polycystic ovary].

A case of inguinal endometriosis is described in a patient affected by PCOD. To the best of our knowledge, this is the first case of this type of association reported in the literature although cases in which endometriosis was related to high estrogen levels are well documented. We suggest that in the presence of high estrogen levels (absolute or relative hyperestrinism), the foci of endometriosis might not prove a rare condition if clinicians and pathologists lashed for it carefully.

Adult↗
PubMed1992

Objective and subjective data for fertile period diagnosis in women: comparison of methods.

The Authors have evaluated the reliability of various methods, both natural and biochemical, for the identification of the female ovulatory period in women with regular periods. They compared these methods among themselves and with echographical checking of ovulation. It emerged clearly from the study that the greatest reliability among the natural methods is obtained through the evaluation of the presence of cervical mucus, while among biochemical methods the best results are obtained by a semiquantitative colorimetric test. Brilliant prospects have also been opened by research on saliva.

Biomarkers↗
PubMed1991

In vitro poly(ADPribosylation) of estrogen-induced proteins from the oviduct of the lizard Podarcis s. sicula Raf.

Poly(ADPribosylation) of nuclear proteins has been investigated in the nuclei from growing oviducts of intact and estrogen-treated spayed females of the lizard Podarcis s. sicula Raf. Isolated nuclei were incubated with [14C] NAD and nuclear proteins extracted in 0.2 m H2SO4. Labeled acid-soluble proteins were analysed by reverse-phase high-performance liquid chromatography (HPLC) and acetic acid-urea gel electrophoresis. The results reported here indicate that the ADPribosylation reaction is involved in modifying besides histone H2b, tissue specific proteins (SNPs and LMG-O). Moreover, comparable results have been obtained from nuclei prepared from the fully active oviduct of intact animals and spayed lizards stimulated with 17 beta-estradiol. It is concluded that the poly-(ADPribosylation) of hormone-induced proteins might play a role in the differentiation of the lizard oviduct.

Amino Acids↗
PubMed1991

Evolution of a centromeric satellite DNA and phylogeny of lacertid lizards.

1. The composition and phyletic distribution of a highly repetitive satellite DNA, isolated from Podarcis sicula, was studied. 2. This DNA was rich in adenine and thymine and displayed frequent adenine stretches. It was always located on the centromeric heterochromatin even in quite taxonomically distant species. 3. Southern blot hybridization of the Taq I satellite on various species of lacertid families showed a close affinity among Podarcis, Algyroides and Lacerta dugesii. 4. All the other taxa investigated did not seem to possess this repeated sequence.

Animals↗
PubMed1983

Prenatal echographic diagnosis of ovarian cyst in a female fetus.

The Authors have diagnosed in antenatal age, by echogram, an ovarian cyst in a female fetus. After birth the newborn was operated. After laparotomy the surgeons found a cyst of the left ovary with this size: cm 9 x cm 11, whose weight was g 400 and with a liquid content. Therefore the Authors point out the validity of the echography in case of congenital fetal abnormalities.

Adult↗