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Biomedical subjects

A Carlsen

Publications and source records attributed to A Carlsen.

16 recordsLinked to original sources
PubMed1994

Outcome of infected total knee arthroplasty.

The results of 44 cases of deep infection after total knee arthroplasty were reviewed. The average age of the patients was 62 years (range, 31-81 years), and all had positive bacterial cultures from deep aspiration or tissue biopsy. Osteitis was revealed in 22 cases. One case was initially treated with antibiotics only, 27 cases were treated with surgical debridement and antibiotics, and 16 cases had immediate removal of the prosthesis. In 21 cases, failed debridement was followed by removal of the prosthesis. Revision arthroplasty was attempted in 15 of the 37 cases in which the prosthesis was removed; the infection was cured in 11 cases. A total of 25 cases that underwent removal of the prosthesis had an arthrodesis performed, and 4 ultimately underwent amputation. In no case of osteitis was the infection cured merely by debridement and antibiotics, and the index prostheses were retained mainly in cases in which osteitis did not develop.

Adult↗
PubMed1988

A functional analysis of multiple aberrant responses: a refinement and extension of Iwata et al.'s (1982) methodology.

This study extends an operant methodology for the analysis of variables which control aberrant responses displayed by mentally handicapped people. The proportion of time spent in individual, stereotyped topographies by three profoundly mentally handicapped subjects was observed by momentary time-sampling whilst they were repeatedly exposed to four analogue environments: Alone, Social Disapproval, Academic Demand and Unstructured Play. Two of the three subjects showed replicable effects of the analogue environments. One subject showed evidence of an interaction between stereotyped topography and type of analogue environment. This study shows that the operant methodology of Iwata et al. (1982), originally developed with self-injurious responses, can be successfully refined and extended to the analysis of a wider range of aberrant topographies.

Adult↗
PubMed1986

Reproducibility of goniometry of the wrist.

The wrist motion in 31 healthy probands was measured by four observers with a simple goniometer under standardized conditions. The INTRA-observer variation was calculated to 5 to 8 degrees and the INTER-observer variation to 6 to 10 degrees. No difference between experienced and non-experienced observers was found. The difference between the right and the left wrist was negligible, indicating that the opposite wrist can be used as reference when evaluating restrictions in motion.

Adult↗
PubMed1978

Different clinical types of lipomatosis. Case report.

Following a brief review of the literature, three characteristic case histories are reported in order to demonstrate the different appearances of lipomatosis. According to the survey, grouping into three main types is suggested: 1) Diffuse lipomatosis without any sharp demarcation from the surrounding soft tissue, and a tendency to recurrence; 2) Diffuse, symmetrical lipomatosis mainly located to the neck region, and 3) Multiple lipomatosis with well-defined, encapsulated, small lipomas which never recur following removal.

Adult↗
PubMed1976

Glycerol transport in human red cells.

The kinetics of 14C-glycerol exchange was studied in human red cells. Glycerol appeared to be transported by two mechanisms: (i) by facilitated diffusion with permeability depending on glycerol concentration, and (ii) by an unspecific pathway, presumably representing the diffusion of individual glycerol molecules through the membrane with permeability independent of glycerol concentration. The latter permeability was 8 X 10(-8) cm/s at 20 degrees C, it was independent of pH, and had an activation energy of 25 kcal/mol. The facilitated transport of glycerol was completely inhibited by Cu++, and the activation energy was low, about 10 kcal/mol. The transport system was competitively inhibited by H+, reacting with at least three hydrogen analogue, as well as dimethylsulfoxide (a hydrogen bonding molecule with no structural resemblance to glycerol), inhibited glycerol transport competitively. Steins "dimerizer hypothesis" was revised according to our findings. A kinetic scheme describing the reactions of a transport controlling site with glycerol is presented in the Appendix. It is demonstrated in the article that the scheme accounts for out experimental results.

Biological Transport↗
PubMedDate not supplied

Campylobacter jejuni strains from patients with Guillain-Barré syndrome.

Guillain-Barré syndrome (GBS), an acute demyelinating peripheral neuropathy, may be triggered by an acute infectious illness; infection with Campylobacter jejuni is the most frequently reported antecedent event. In Japan, O:19 is the most common serotype among GBS-associated C. jejuni strains. To determine whether serotype O:19 occurs among GBS-associated strains in the United States and Europe, we serotyped seven such strains and found that two (29%) of seven GBS-associated strains from patients in the United States and Germany were serotype O:19. To determine whether GBS-associated strains may be resistant to killing by normal human serum (NHS), we studied the serum susceptibility of 17 GBS- and 27 enteritis-associated strains (including many O:19 and non-O:19 strains) using C. jejuni antibody positive (pool 1) or negative (pool 2) human serum. Using pool 1 serum we found that one (6%) of 18 serotype O:19 strains compared with 11 (42%) of 26 non-O:19 strains were killed; results using pool 2 serum were nearly identical. Finally, 8 O:19 and 8 non-O:19 strains were not significantly different in their ability to bind complement component C3. Serotype O:19 C. jejuni strains were overrepresented among GBS-associated strains in the United States and Germany and were significantly more serum-resistant than non-O:19 strains. The mechanism of this resistance appears unrelated to C3 binding.

Blood Bactericidal Activity↗
PubMedDate not supplied

'Practice makes perfect'.

Several group practices around the country are offering innovative services to meet the needs of their older patients. The Zitter Group, in conjunction with MGMA/CRAHCA and Syntex Laboratories, conducted a nationwide contest to find the most outstanding of these programs and the winners are featured in this article.

Aged↗
PubMedDate not supplied

Surveying medical groups in an aging America.

The Zitter Group also used an educational grant from Syntex Laboratories to survey medical groups on how the aging of the population is affecting them and how they are responding. The results are featured in this article by Connie Mahoney, Ph.D., and Amy Carlesen.

Aged↗