Biomedical subjects

A Castaneyra-Perdomo

Publications and source records attributed to A Castaneyra-Perdomo.

2 recordsLinked to original sources

PubMed1995

Alcohol effects on paraventricular hypothalamic nucleus morphometry.

The morphometric effects of postnatal exposure to alcohol on the neurons of the paraventricular hypothalamic nucleus (PVN) have been studied in four different topographic subdivisions of the nucleus: rostral, intermediate medial, intermediate lateral and caudal. Male mice were exposed to alcohol during lactation and after weaning by addition of 20% of ethanol to the drinking water that was first ingested by the mother and thereafter by the experimental animals themselves. Animals were sacrificed at the 25th, 35th, 45th, 55th and 100th postnatal day. Nuclear sizes of the PVN neurons (Perimeter, area and maximum diameter) were determined in both control and experimental alcohol-treated groups. The shape of these neuronal nuclei was also determined and compared. PVN responds globally to alcohol exposure, showing a decrease in the neuronal nuclear sizes in the four studied PVN subdivisions of the alcohol-treated mice at the 35th and 45th and 100th day. We suggest that these decreases could be related to changes in gonadal hormone levels induced by alcohol exposure and/or disturbances of brain neurotransmitter and neuropeptide metabolism caused by ethanol.

Animals↗

PubMed1992

Morphology of neurons in the white matter of the adult human neocortex.

Neurons in the human cerebral cortical white matter below motor, visual, auditory and prefrontal orbital areas have been studied with the Golgi method, immunohistochemistry and diaphorase histochemistry. The majority of white matter neurons are pyramidal cells displaying the typical polarized, spiny dendritic system. The morphological variety includes stellate forms as well as bipolar pyramidal cells, and the expression of a certain morphological phenotype seems to depend on the position of the neuron. Spineless nonpyramidal neurons with multipolar to bitufted dendritic fields constitute less than 10% of the neurons stained for microtubule associated protein (MAP-2). Only 3% of the MAP-2 immunoreactive neurons display nicotine adenine dinucleotide-diaphorase activity. The white matter pyramidal neurons are arranged in radial rows continuous with the columns of layer VI neurons. Neuron density is highest below layer VI, and decreases with increasing distance from the gray matter. White matter neurons are especially abundant below the primary motor cortex, and are least frequent below the visual cortex area 17. In contrast to other mammalian species, the white matter neurons in man are not only present during development, but persist throughout life.

Adult↗