[Post-trephining cranial defects in children].
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Adolescent↗
Biomedical subjects
A Cedro
Publications and source records attributed to A Cedro.
[Perforation of the wall of the small intestine in a newborn. Rare complication following exchange transfusion].
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Exchange Transfusion, Whole Blood↗
[A map of delusional world according to Zdzisław Bizoń].
The paper describes an instrument for presentation of content of delusions, which thanks to its synthetic graphic form, leads to improved systematization and understanding of delusional beliefs.
Adult↗
The surgical approach to hyperinsulinism and hypoglycemia in children.
Authors present 19 children aged from 2 weeks to 16 y with severe hypoglycemia. In 3 oldest children a single nesidioma was found. In other 16 children mainly infants nesidioblastosis has been recognised, and in those cases the subtotal pancreatectomy was performed. In 4 infants the additional resection of the pancreas was done because after the primary procedure hypoglycemia persisted. All patients survived and were euglycemic. Severe hypoglycemia leads to brain damage and therefore should be treated as an urgent state.
Adolescent↗
Enzymatic hydrolysis of DNA using a membrane bioreactor.
Aim of this work was a kinetic study of the deoxyribonuclease I (E.C. 3.1.21.1.) reaction in several conditions. Optimal reaction conditions with enzyme free in solution were determined. DNase activity was studied as function of several parameters such as pH, enzyme concentration, substrate concentration, cofactor concentration. The Km value of the free enzyme was also determined. Subsequently, the possibility to carry out the reaction in systems in which the enzyme was immobilized on the inner surface of the polymeric membranes was evaluated and realized. Experimental procedures, in these new conditions, permitted to determine the mass of immobilized enzyme and the percentage of the reaction product recovery. Results showed that the immobilization procedure determines a decay of the initial activity of enzyme, but there is an important increase of enzyme stability.
Animals↗
[Carbamazepine in the treatment of alcohol withdrawal].
The authors present a review of literature on the initial rationale and efficacy in clinical trials of carbamazepine (CBZ) in the treatment of alcohol withdrawal, and the pharmacokinetics of carbamazepine in alcoholics as well. Neurophysiological and clinical studies support the kindling hypothesis in the pathophysiology of alcohol withdrawal. The exact physiological action mechanism of CBZ has not been entirely examined. However, the "antikindling effects" are of particular importance in epilepsy and other neurological and psychiatric conditions. Numerous controlled studies were able to demonstrate the effectiveness of carbamazepine in the treatment of alcohol withdrawal symptoms and have compared its properties to other drugs such as clomethiazole and benzodiazepines. Carbamazepine could be a useful alternative to conventional therapeutic approaches, especially in the treatment of mild and moderate alcohol withdrawal symptoms, and alcohol withdrawal with generalized tonic-clonic seizures.
Anticonvulsants↗