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Biomedical subjects

A Celis

Publications and source records attributed to A Celis.

8 recordsLinked to original sources
PubMed1979

Demonstration of dissimilar acute haemodynamic effects of ethanol and acetaldehyde.

To determine whether the acute cardiac depressant effects of ethanol could be attributed to its metabolite (acetaldehyde), either ethanol or acetaldehyde was intravenously infused into pentobarbital anaesthetised, closed-chest dogs. At a venous blood ethanol level of 199 +/- 43 (SE) mg . dl-1, ejection fraction had decreased from 35 +/- 2 to 30 +/-2%, P less than 0.05, max dP/dt/end-diastolic volume from 14.0 +/- 2.1 to 8.6 +/- 1.1 kPa . s-1 . cm-3 (105 +/- 16 to 65 +/- 8 mmHg . s-1 . cm-3), P less than 0.02, whereas end-diastolic volume (P less than 0.005), myocardial oxygen consumption (P less than 0.05) and coronary blood flow (P less than 0.005) had increased. Higher ethanol levels exaggerated these changes when peak arterial acetaldehyde was 20.2 +/- mumol . litre-1. By contrast, infusion of acetaldehyde to a peak blood level comparable with that produced by ethanol increased cardiac output from 2.4 +/- 0.2 to 2.8 +/- 0.2 litre-1 . min-1 P less than 0.01), coronary sinus oxygen saturation from 46 +/- 4 to 55 +/- 3% (P less than 0.25) and reduced systemic resistance from 8.0 +/- 0.7 to 6.3 +/- 0.5 kPa . litre-1 . min-1 (60 +/- 5 to 47 +/- 4 mmHg . litre-1 . min-1) (P less than 0.001). High dosage of acetaldehyde to a level of 129 +/- 23 mumol . litre-1 produced elevation of cardiac output (P less than 0.001), ejection fraction (P less than 0.01), coronary blood flow (P less than 0.02), whereas systemic resistance (P less than 0.001), heart rate (P less than 0.05) and myocardial oxygen consumption (P less than 0.05) decreased. Discontinuation of acetaldehyde infusion significantly reversed these changes. Max dP/dt/left ventricular end-diastolic volume and left ventricular end-diastolic volume were not significantly altered by acetaldehyde. Thus, ethanol depresses cardiac performance and increases myocardial oxygen consumption. By contrast, acetaldehyde at levels produced by ethanol metabolism improves cardiac performance, consequent to afterload reduction, and reduces myocardial oxygen consumption.

Acetaldehyde↗
PubMedDate not supplied

[Drowning in Jalisco: 1983-1989].

The objective of this work was to identify which preventive factors are involved in drowning. Files of 895 autopsies from 1983 through 1989 by the coroner site office were reviewed. During this seven year period, the annual mortality for drowning was 2.6 per 100,000 population. Males had a higher annual mortality rate (4.2 per 100,000) than females (1.1 per 100,000). The age group between one and four years old had the highest mortality rate (7.6 per 100,000). Deaths tend to cluster around summer. Most of the deaths occurred in house cisterns (19.3%), dams/lakes (16.9%), rivers/canals (14.3%), water wells (12.5%) and swimming pools (10.1%). A third of the deaths occurred at home. The relationship alcohol-drowning starts to stand out in the age group between 10 and 14 years old but get its highest percentage in the age group 35-39 (74%). There are two important findings that is necessary to point out: drowning occurring at home and the relationship between drowning and alcohol ingestion.

Accidents, Home↗
PubMedDate not supplied

[Traumatism and poisoning in Jalisco. An autopsy-based study on mortality].

The objective of this study was to obtain better information about deaths labeled as "injuries" in the Mexican state of Jalisco than that reported by official agencies. We reviewed 1989 reports of medical-legal autopsies from the whole state. Deaths were classified in relation to external cause, age, sex and alcohol. It was found that the first five most frequent causes of death by injury were: traffic accidents (14.3 x 100,000), homicides (10.0 x 100,000), other accidents (6.1 x 100,000), accidental asphyxia (3.2 x 100,000) and, suicide (2.3 x 100,000). Four fifths of the deaths were in men. The most affected age group was older than 64 (86.6 x 100,000). The rate of alcohol-related deaths was divided in homicides (51.1%), accidents (26.5%) and, suicides (28.7%), with a statistically significant difference (p less than 0.001). It is concluded that the results of this study are more accurate in their external cause than those obtained through death certificates, and the importance that the registrar's office has for the timely recording and study of injuries is emphasized.

Adolescent↗