[Certain central effects of calcitonin and parathormone].
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Calcitonin↗
Biomedical subjects
A Ceravolo
Publications and source records attributed to A Ceravolo.
Prolactin influences sexual behavior during aging.
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Aging↗
Effect of calcitonin on ACTH secretion.
We have investigated the effects of salmon calcitonin injected intracerebroventricularly on adrenocorticotropic (ACTH) secretion in rats. Salmon calcitonin was able to increase significantly (p less than 0.05) ACTH secretion at the dose of 5 ng/rat and (p less than 0.01) at the doses of 12.5, 25 and 50 ng/rat; the effect (50 ng/rat) was maximal at 30 min and still present after 60 and 120 min. The maximal dose of calcitonin produced a significant (p less than 0.05) increase in serum ACTH concentration also in stressed animals. It is suggested that calcitonin may increase serum ACTH secretion by central norepinephrine and/or 5-hydroxytryptamine pathways that regulate corticotropic releasing factor activity.
Adrenocorticotropic Hormone↗
Glomerular lesions in experimental infections of Schistosoma mansoni in Cebus apella monkeys.
Three monkeys (Cebus apella) experimentally infected with Schistosoma mansoni studied for periods of 19, 14, and 11 months showed deposits containing gamma-globulin in subendothelial and subepithelial basal membranes and in basement membranes proper. The glomeruli showed mild reactivity characterized by local hypertrophy and hyperplasia of mesangial cells. Such findings were close to those observed by us in the kidney of hepatosplenic schistosomiasis patients without evidence of renal disease. The distribution of the deposits, both in human and experimental disease, are suggestive of preformed, non-glomerular antigen-antibody complexes that form in a zone of excess antigen and become trapped in the glomerular capillaries.The possibility exists, but has not yet been proved beyond doubt, that renal disease in schistosomiasis patients could be the end result of this pathogenetic mechanism.
Animals↗