Biomedical subjects

A Ceyhun Akcay

Publications and source records attributed to A Ceyhun Akcay.

3 recordsLinked to original sources

PubMed2005

Effect of source spectral shape on task-based assessment of detection and resolution in optical coherence tomography.

We demonstrate the effect of the spectral shape of broadband light sources in a task-based approach for assessment of signal detection and resolution in optical coherence tomography. We define two binary tasks: The signal is either present or absent and the signal can be either resolved or not. In a transparent sample bounded by two uniform interfaces we study the minimum detectable change in the index of refraction as well as the minimum resolvable distance between the layers in correlation with the source spectral shape and power. Results show that the area under the receiver operating curve (AUC) for a signal-detection task is not affected by the shape of the spectrum but solely by its optical power, whereas spectral shaping has an effect, which we quantify, on the AUC for the resolution task. Moreover, the AUC is demonstrated in relation to the concept of system sensitivity for a signal-detection task.

Algorithms↗

PubMed2005

Dispersion control with a Fourier-domain optical delay line in a fiber-optic imaging interferometer.

Recently, Fourier-domain (FD) optical delay lines (ODLs) were introduced for high-speed scanning and dispersion compensation in imaging interferometry. We investigate the effect of first- and second-order dispersion on the photocurrent signal associated with an optical coherence imaging system implemented with a single-mode fiber, a superluminescent diode centered at 950 nm +/- 35 nm, a FD ODL, a mirror, and a layered LiTAO3 that has suitable dispersion characteristics to model a skin specimen. We present a practical and useful method to minimize the effect of dispersion through the interferometer and the specimen combined, as well as to quantify the results using two general metrics for resolution. Theoretical and associated experimental results show that, under the optimum solution, the maximum broadening of the point-spread function through a 1-mm-deep specimen is limited to 57% of its original rms width value (i.e., 8.1 microm optimal, 12.7 microm at maximum broadening) compared with approximately 110% when compensation is performed without the specimen taken into account.

Animals↗

PubMed2003

Spectral shaping to improve the point spread function in optical coherence tomography.

We demonstrate inhibition of the sidelobes of the axial point spread function in optical coherence tomography by shaping the power spectrum of the light source with a remaining power of 4.54 mW. A broadband amplified spontaneous emission source radiating at 1565 +/- 40 nm is employed in a free-space optical coherence tomography system. The axial point spread functions before and after optical spectral shaping are presented. Results show that spectral shaping of the source can inhibit sidelobes of the point spread function up to 12.9 dB, with an associated small increase of 2.2 dB in noise floor in the far field. The effect of spectral shaping on axial resolution is demonstrated according to three metrics. Image quality improvement is also illustrated with optical coherence tomography images of an onion before and after spectral shaping.

Equipment Design↗