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A Chanana

Publications and source records attributed to A Chanana.

5 recordsLinked to original sources
PubMed2000

Postmortem neuropathological features secondary to boron neutron capture therapy for glioblastoma multiforme.

This postmortem study of 12 patients with glioblastoma multiforme (GBM) treated with boron neutron capture therapy (BNCT) employing an epithermal neutron beam and p-boronophenylalanine describes the neuropathological findings in patients receiving a relatively high radiation dose to the tumor, but a relatively low radiation dose to the normal brain. In addition to a standardized neuropathology panel of sections, we used individual treatment dosimetry maps to select sections along the projected maximum radiation beam pathway. We found that the normal neuroparenchyma exposed to the highest radiation dose exhibited a single instance of radiation-induced focal venular fibrinoid necrosis and a single instance of multifocal demyelination. Semiquantitative analysis of pretreatment neurosurgical and postmortem tumor samples revealed only two radiation ascribed histopathological findings to be particular to therapy, fibrinoid necrosis and vascular hyalinization. In this relatively small series of cases we found an unexpectedly high frequency of cases (3 of 12) with neurodegenerative histopathology (Lewy bodies, neurofibrillary tangles, and neuritic senile plaques), which appeared, by distribution, to be independent of the radiation beam. Two of these patients were over 70 yr of age. One was only 41. Our findings suggest an acceptable radiation-induced level of neurotoxicity at the lower doses employed, but raise the possibility of unexpected boron neurodegenerative toxicity.

Adult↗
PubMed1998

Explaining the effect of ethnic group on weight concern: finding a role for family values.

OBJECTIVE: To examine the impact of ethnic group on aspects of weight concern and to assess the role of family values in explaining this association. SUBJECTS AND MEASURES: 20 Asian and 20 white daughters gave a questionnaire to their mother, father and sibling closest in age, concerning their profile characteristics (age, education) values and beliefs and completed a matched questionnaire containing additional measures of aspects of their weight concern. RESULTS: The results showed no differences between the white and Asian daughters in terms of either their restrained eating or body dissatisfaction. However, the results showed consistent differences between the members of the two family groups in terms of the value placed on achievement, child/parent relationships, competition, the role of women, and some differences in terms of materialism, the value of appearance and their idea of the perfect female body. The results were then analysed to assess the best predictors of the daughter's weight concern. Whereas restrained eating was related to the mother's rating of the value of physical appearance and the sibling's ratings of competitiveness and a non-traditional role for women (40% of the variance), the results showed that body dissatisfaction was related to the daughter's rating of materialism, having a father who preferred a thinner female body, the siblings ratings of a non-traditional role for women, degree of concordance within the family concerning the value of competitiveness and the educational level of the 'head of the family' (49% of variance). CONCLUSION: Whereas a dichotomous model of ethnicity may be insufficient to explain differences in aspects of weight concern, an expanded model of cultural beliefs may be a more powerful construct. Accordingly, the absence or presence of differences in weight concern according to ethnic group may simply reflect the extent to which the different groups chosen for analysis are differentiated by these predictive values.

Adolescent↗
PubMed1997

Pulmonary involvement in unusual multisystem disorders.

The clinical syndrome of interstitial lung disease encompasses a number of clinical disorders that affect the alveolar walls, interstitium, and vicinal structures including small airway and pulmonary vasculature. The syndrome has more than 200 causes including bacterial, viral, fungal, protozoal, and parasitic infections; collagen vascular disorders including systemic lupus erythematosus, rheumatoid arthritis, progressive systemic sclerosis, ankylosing spondylitis, mixed connective tissue disease, Sjögren's syndrome, and various vasculitides; hypersensitivity lung disease or extrinsic allergic alveolitis; inorganic neumoconioses including silicosis, asbestosis, and berylliosis; drug-induced and iatrogenic entities; and disorders of unknown origin including sarcoidosis, idiopathic pulmonary fibrosis, eosinophilic granulomatosis, lymphangioleiomyomatosis, and bronchiolitis obliterans-organizing pneumonitis. Apart from these, there are many uncommon metabolic and immune disorders that can involve pulmonary interstitium. Recently developed epidemiologic, immunologic, and molecular biology techniques undoubtedly will add to the list other entities that may produce interstitial lung disease.

Female↗
PubMed1987

Implication of Ia-positive bone marrow interstitial stem cells in the induction of unresponsiveness to canine renal allografts.

The removal from stored autologous host bone marrow of a monocytoid cell population by exposure to methylprednisolone is associated with successful introduction of unresponsiveness to renal allografts in irradiated recipients reconstituted with such treated marrow. The eliminated cells are a prominent component of the canine long bone marrow interstitium and share a number of important properties with dendritic cells (DC), including size and shape; poor or nonadherence to plastic or glass surfaces; negative staining for neutral esterase, acid phosphatase, or peroxidase; nonphagocytic; Ia positive, but negative for IgG or IgM; ability to act as accessory cells in augmenting the intensity of allogeneic mixed-lymphocyte reactions. Both cell types are of bone marrow origin and are susceptible to steroids in vitro. The results suggest that the bone marrow interstitial cells identified in the course of this study may be enriched with populations of canine dendritic cell precursors and dendritic cells at various stages of differentiation. The detection of a receptor site for Helix promatia on the surface of such cells may be of usefulness in their further characterization and in the analysis of their precise role in the modulation of allogeneic unresponsiveness.

Animals↗