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Biomedical subjects

A Charpentier

Publications and source records attributed to A Charpentier.

At least 55 records · Page 3Linked to original sources
PubMed1991

Concepts of remission, curability and lineage involvement in relationship to the problems of minimal residual leukaemia.

Minimal residual leukaemia (MRL) is due to chemotherapeutic failure. Chemoincurability in chronic myeloid leukaemia and in myelodysplastic syndrome is the norm and is the result of tumour defect arising within the marrow stem cell compartment. We propose that this is indeed the state of affairs in the majority of adult acute leukaemias and such tumours derived from stem cells are chemoincurable. The proportion of acute leukaemias which belong to this category can only be cured by allogeneic bone marrow transplantation though conventional chemotherapy and autotransplant may result in prolonged periods of remission and a return to a preleukaemic state in some patients. A proportion of the acute leukaemias occurring predominantly in children are presently curable by chemotherapy. It is hypothesized that these chemocurable leukaemias derive from the compartment of haemopoietic progenitors already irreversibly committed to a single lineage. Some recent studies using markers of the leukaemic clone to determine the origin of in vitro myeloid colony forming cells support this concept. Intrinsic and/or acquired genetic chemoresistance represents a supplementary restriction to the chemocurability of acute leukaemias. New methods of detecting MRL are sensitive enough to detect up to one leukaemic cell in 10(6) bone marrow mononuclear cells. However, it is possible that even such sensitive techniques will not be sufficient to determine whether patients in complete remission continue to harbour leukaemic cells in the stem cell compartment when the marker of interest might not be expressed.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1991

Mapping point mutations in the Drosophila rosy locus using denaturing gradient gel blots.

Mutations within the rosy locus of Drosophila were mapped using blots of genomic DNA fragments separated on denaturing gradient gels. DNA sequence differences between otherwise identical small rosy DNA fragments were detected among the mutants as mobility shifts on the blots. Mutations were mapped to within a few hundred base pairs of rosy sequence in 100 of 130 mutants tested--a 77% detection rate. The sequence changes in 43 rosy mutations are presented; all but six of these were single base changes. Thirty-four of 36 sequenced mutations induced by the alkylating agents N-ethyl-N-nitrosourea and ethyl methanesulfonate were transitions. All of the mutations mapped in the rosy transcription unit. Twenty-three of the 43 sequenced mutations change the predicted rosy gene polypeptide sequence; the remainder would interrupt protein translation (17), or disrupt mRNA processing (3).

Animals↗
PubMed1985

[Incidence of acquired infection in the surgical departments of 5 hospitals].

A program for monitoring nosocomial infections was implemented in the surgical units of five hospitals. The overall incidence of infections after clean surgery varied from 6.6% to 15% depending on the units. Surgical wound infections were in the 2.8 to 5% range, which corresponded to 30-66% of nosocomial infections. The main septic complication of surgery in 2 of the 5 units was urinary tract infection, with an incidence of 1.6 to 7.8%. Bacteriaemia complicating urinary tract infections and intravenous catheter infections accounted for 4% to 16% of all infections. Staphylococcus aureus was responsible for 40 to 77% of surgical wound infections and Escherichia coli for 30 to 50% of urinary tract infections. After a 4-5 months period of monitoring, the incidence of nosocomial infections was reduced by 32 to 68% depending on individual units.

Cross Infection↗
PubMed1975

[Acebutolol test in moderate arterial hypertension. Action on systolic time intervals].

The antihypertensive effect of acebutolol, a new cardioselective beta-blocking drug, is studied in 31 patients with mild essential hypertension. Administration of acebutolol (2,000 mg) in 48 hours produced a significant decrease in blood pressure, heart rate, plasma renin activity (P.R.A.) and an increase in systolic time intervals (pre-ejection period and isovolumetric contraction time). The blood pressure drop is highly correlated to the initial P.R.A. values, but is not related either to the initial heart rate, or to the systolic time intervals values.

Acebutolol↗