Mycoplasma pneumonia with bilateral pleural effusions.
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Adolescent↗
Biomedical subjects
A Chester
Publications and source records attributed to A Chester.
Heparinization in aortic surgery.
A prospective study was conducted on 35 patients (25 males and 10 females) undergoing elective reconstructive aortic surgery to examine the heparin activity after a bolus dose of sodium heparin (100 U/kg) given five minutes prior to aortic cross clamping. Recording of heparin activity were made 15 minutes later, on release of the aortic clamp, at abdominal wound closure and hourly thereafter until minimal activity was reached. In 10 patients, protamine was used to reverse anticoagulation. These results were related to clinical parameters of age, renal function, plasma cholesterol, blood pressure, position of the aortic clamp and blood loss. High peak levels of heparin activity were more likely in patients with impaired renal function or high plasma cholesterol concentrations. Heparin activity was prolonged at therapeutic levels in patients with renal impairment, and in this group of patients the use of protamine was significantly increased as was the requirement for blood replacement.
Aged↗
Behavioral methods in reproductive and developmental toxicology.
A questionnaire was sent to 75 representatives of 71 pharmaceutical companies or toxicology contract laboratories to determine the extent of behavioral teratology (neurobehavioral development) testing currently conducted by the pharmaceutical industry. The form used was a modification of one used by Buelke-Sam and Kimmel. The present survey made inquiry about test methods employed, test species, animal age at testing. CNS functions believed to be measured, other toxicologic endpoints measured concomitantly, correlation of other observations with behavioral alterations, advantages and disadvantages of test methods used, influence of current regulatory requirements on the extent of testing, and utilization of positive controls. Forty-five responses (60%) were received and 26 of these (58%) indicated that some behavioral testing was being conducted. None of the respondents was performing the same combination of specific tests or classes of tests. As in 1978, testing facilities acknowledged a need for some kind of behavioral testing, but with flexibility as to specific methods. Of 13 specified classes of behavior, about half of the respondents were testing 6 classes or more of behavior and were evaluating all agents under development. The primary test subject was the weanling rat. Overall, there have been no major changes in the frequency of sampling from behavioral classes or use of specific tests of behavior since 1978.
Animals↗
Phase II trial of vindesine in the treatment of lymphomas, breast cancer, and other solid tumors.
A phase II study of vindesine in 41 evaluable patients demonstrated the drug to be active in heavily pretreated patients with breast cancer, non-Hodgkin's lymphoma, and other tumors. There were two partial responses in 11 patients with breast cancer (18%) and five partial responses and one complete response in 11 patients with non-Hodgkin's lymphoma (40%). Other responses were seen in small cell carcinoma of the lung, ovarian carcinoma, and Hodgkin's disease. Prior vinca exposure did not adversely affect the response rate. Neutropenia was dose-limiting. Neurotoxic effects occurred in 10% of the patients. A high incidence of local tissue reactions at the injection site (27%) could be reduced by a careful administration technique. Vindesine should be studied further in combination with other agents.
Aged↗