Biomedical subjects

A Cicconetti

Publications and source records attributed to A Cicconetti.

24 records · Page 2Linked to original sources

PubMedDate not supplied

Effect of mirtazapine on thyroid hormones in adult patients with major depression.

Hypothalamic pituitary thyroid (HPT) axis abnormalities and alterations in major depression are reported in the literature. The aim of our study was to evaluate the effect of mirtazapine on thyroid hormones after 6 months of therapy in a sample of adult outpatients with Major Depression (MD). 17 adult outpatients (7 men, 10 women) with MD according to DSM-IV criteria, were included in the study. All participants had to have met criteria for a major depressive episode with a score of at least 15 on the Hamilton Depression Rating Scale (HAM-D). Fasting venous blood samples were obtained for determination of serum Thyroid Stimulating Hormone (TSH), Free T3 (FT3) and Free T4 (FT4) concentrations both at baseline and after 6 months of therapy. HAM-D scores decreased significantly from the first day of treatment to the end of the treatment period (P<0.001) and twelve patients (70.6%) were classified as responders. A significant increase in FT3 concentrations was found between baseline and the end of the treatment period (P=0.015), whereas FT4 concentrations decreased (P=0.046). No significant changes were found in TSH levels. Higher FT4 concentrations at baseline predicted higher HAM-D scorers both at baseline and at the end of the treatment period. Furthermore, higher FT3 concentrations at endpoint were found to be predictors of lower HAM-D scores. Long-term treatment with mirtazapine increases FT3 levels and decreases FT4 maybe involving the deiodination process of T4 into T3.

Adult↗

PubMedDate not supplied

[Surgical approach to benign primary tumors of the para-pharyngeal space].

Surgical access to tumors of the parapharyngeal space can be performed by transoral or trancervical approaches. Risk of intraoperative bleeding and difficulties in radical enucleation represent the disadvantages of transoral approach. This approach must be performed for small and inferomedial lesions, or for preoperative biopsy when necessary. Transcervical approaches can be distinguished in transparotid or transmandibular, or submandibular. Before the late '70s all parapharyngeal masses were approached by transparotid access, with facial nerve manipulation in all cases. CT and MR techniques now allow the right presumptive preoperative diagnosis in 90% of patients. To avoid the risk of injury of the facial nerve when possible, transparotid approach is now limited to the lesions with parotid origin. Transmandibular and submandibular approaches allow an adequate exposure and a direct access to the parapharyngeal space. Personal experience with 6 patients presenting primitive tumors of the parapharyngeal space is reported and surgical approaches proposed in the literature are reviewed.

Adenoma, Pleomorphic↗

PubMedDate not supplied

Benign cementoblastoma: a clinical case of conservative surgical treatment of the involved tooth.

The benign cementoblastoma (BC) or ''true'' cementoma is a rare benign neoplasm arising from the odontogenic ectomesenchyme and representing about 1% to 6.2% of all odontogenic tumors. The BC more frequently affects young males in an age range of 20-30 years, occurring in the mandible about 3 times more than in the maxilla, and it is always physically attached to the tooth roots. This tumor is often asymptomatic until it produces pain, expansion or swelling of the jaw segment or compression of the inferior alveolar nerve. Early diagnosis is essential to save the tooth by enucleating the tumor, filling the root canals and apicectomy or curettage of the affected roots. A case of BC embedding the mandibular first right molar and resorbing the vestibular cortical bone, in a 48 year-old male, is reported. The radiographic examination showed a well-defined mixed-density unilocular mass, confluent with both the tooth roots of the mandibular first molar and surrounded by a radiolucent rim. A combined endodontic-surgical treatment was performed with the aim to remove the tumor while saving the tooth. Histological findings, differential diagnosis and surgical treatment of the tumor are discussed and compared with similar cases in the literature.

Dental Cementum↗

PubMedDate not supplied

[Hemifacial microsomia: cephalometric evaluation].

Among the facial deformities one of the most frequent is the hemifacial microsomia. The Authors after a revision of the literature refer about their study. They utilize lateral, antero-posterior cephalometry and orthopantomogram to exactly identify the deformities. The Authors report the results of the analysis and emphasize that the functional alterations of the stomatologic system are of basical importance in the genesis of the syndrome.

Cephalometry↗

PubMedDate not supplied

[Intraoral reconstruction with radial forearm flap].

The intraoral region include structures that represent a functional matrix for the physiology of this region. The reconstructive problems of this area are centred around difficulties to obtain thin flaps that provide coverage without excessive bulk and uninhibited tongue motion. For this regions the radial forearm flap is particularly suited to intraoral reconstruction because it is thin, minimally hair bearing and with moderate donor site morbidity. The Authors report their experience in 6 cases of intraoral reconstruction with radial forearm flap and analyzes it's surgical, anatomical and anatomopathological features. The advantage, the svantage and the indications of this flap are discussed.

Aged↗

PubMedDate not supplied

[The use of the jejunum free flap in the reconstruction of the oral cavity].

The rapid development of surgical techniques in the head and neck area has greatly assisted in enabling reconstructive surgery to bring about prompt positive results. Radical tumor excision alone is no longer an acceptable treatment. Through new reconstructive techniques, psychological and social isolation of the patients, due to difficulties in such vital functions as chewing, speech, swallowing and breathing, can be reduced remarkably. In the past numerous techniques which employed myocutaneous flaps in the reconstruction of the oropharynx have been described. During the last ten years, however, many Authors have proposed the use of free flaps for this reconstructive surgery. Our Department presents its personal experience in reconstruction of the oral cavity using the jejunal flap, which facilitates superior physiological and histological adaptation when compared to that had with other flaps. Our histological study shows metaplastic transformation of the columnar epithelium into squamous epithelium (similar to oral cavity epithelium), phenomenon already observed in "cervix uteri" and anorectal area. The primary reconstruction with a free revascularized jejunal loop associated with mandibular replacement offers certain significant advantages such as satisfactory reconstruction of large defects, high flexibility of the flap and a productions of mucous which cleans the surface of transplants. Furthermore, the mesenteric foot tissue serves as good transplant material for extended soft-tissue loss. In agreement with a Study begun by Carrel in 1906 and that of Reuther (1982), we believe that reconstruction of large defects in the oral cavity by means of transplantation of the mucosa is the ideal treatment.

Adult↗