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Biomedical subjects

A Cinel

Publications and source records attributed to A Cinel.

31 records · Page 2Linked to original sources
PubMed1982

Lymphoplasmacyte infiltrate in cervical intraepithelial neoplasia grade III.

The behaviour of the lymphoplasmacyte reaction, regarded as an immune defence reaction of the organism, has been evaluated in 167 patients affected by cervical intraepithelial neoplasia or by microcarcinoma. It was observed that in surely in situ forms (atypical metaplasia, severe dysplasia and carcinoma in situ) there is a clear prevalence of cases with a minimal or absent reaction, while in the potentially invasive carcinoma and in the microcarcinoma there is a predominance of cases with a marked reaction, as if the first biological modifications that lead to invasion were accompanied by a massive activation of the immune defence mechanisms. We finally noticed that no relation exists between the appearance of CIN-lesion recurrences and the intensity of the stromal reaction. This further confirms the hypothesis that in the first steps of the carcinogenic process exogenous causes are mainly involved.

Adult↗
PubMed1982

Post treatment behaviour of cervical intraepithelial neoplasia - grade III.

The behaviour in time of cervical intraepithelial neoplasia grade III has been evaluated in 141 patients treated for CIN III. It was observed that surgery ensures the higher healing-rate, whether hysterectomy or conization are performed, while diathermocoagulation seems unsatisfactory. Colposcopy, colpocytology and sight biopsies of the cervical canal, portio and vagina, which provide a precise lesion-map, are then essential investigations to make the subsequent treatment a truly radical one. A very close monitoring of patients, treated for CIN III, seems required in the first year after surgery, when we observed the highest rate of persistence and recurrences, while, subsequently, their incidence decreases as time passes by.

Biopsy↗
PubMedDate not supplied

Intraductal papilloma and papillomatosis.

The benign papillary neoplasms of the breast are still controversial topics in general surgery. There are two forms of the benign papillary lesions, solitary intraductal papilloma and multiple intraductal papilloma. These disorders are very rare and their clinical behaviour is different in each case. In this study, two cases of the multiple intraductal papilloma are presented and clinical findings and surgical therapy are discussed.

Adult↗
PubMedDate not supplied

Complicated marginal ulcers after surgery for duodenal ulcer.

During a period of 10 years, 10 cases of marginal ulcer (MU) after surgery for duodenal ulcer were evaluated retrospectively. The most common cause of MU was inadequate gastric resection plus incomplete vagotomy; the second common cause was incomplete vagotomy. In one case, the MU could be ascribed to malignant gastrinoma. In eight of the ten cases epigastric pain was a major symptom. MU was complicated with perforation, massive bleeding, gastrojejunocolic fistula and afferent loop obstruction in 2, 2, 2, and 1 cases, respectively. Gastroscopy was very useful for the diagnosis except in emergency cases. Hollander test was used in six of the 10 patients to evaluate if the vagotomy had been complete. The mean acid output by insulin induction was found 32 meq/h. As a surgical therapy, total gastrectomy (2 cases), truncal vagotomy (2 cases), truncal vagotomy plus 60% gastric resection or reresection and Roux Y gastrojejunostomy were performed. Postoperative complications (enterocutaneous fistula, intraabdominal abscess and delayed gastric emptying) occurred in 33 patients. One patient was lost after total gastrectomy in the malignant gastrinoma and gastrojejunocolic fistula case, due to sepsis. The patients were followed up for 4.4 years on the average. No recurrence was seen.

Adult↗
PubMedDate not supplied

Complications of 867 thyroidectomies performed in a region of endemic goiter in Turkey.

This article aims to define the incidence of complications in 867 thyroidectomies performed by residents with attending surgeons' supervision as part of a training programme, in a region of endemic goiter. Seven hundred and nine patients were female and 158 were male. The age of the patients ranged between 6 and 76 and mean age was 32.5. Cases were divided into two groups according to their disease nature. Group 1 included 805 patients with nodular colloidal goiter (NCG) and adenomas. The remaining 62 cases, 25 with recurrence of goiter (RG), 21 with thyroid malignancy (TM) and 16 with thyroiditis formed group 2. While the overall complication rate was 11.3% (93 cases) in group 1, it was 20.9% (13 cases) in group 2. The mortality rate was zero in both groups. The incidence of complications of 867 thyroidectomies performed by residents with the attending surgeons' supervision was within acceptable limits especially as far as group 1 was concerned. However we suggested that attending surgeons themselves, disregarding residents training, should perform the operation in special cases such as recurrent goiters, thyroid carcinomas with positive regional lymph nodes and thyroiditis with regional adhesions.

Adolescent↗
PubMedDate not supplied

The effects of variously performed vagotomies on gastric secretion and gastric emptying in rats.

The main purpose of this study was to investigate the effects of (i) truncal vagotomy + pyloroplasty, (ii) proximal cell vagotomy and (iii) anterior proximal cell vagotomy + posterior truncal vagotomy on the gastric secretion and gastric emptying in rats. After vagotomy basal and 2-deoxy-glucose stimulated gastric secretion decreased significantly in all three vagotomy groups. Gastric secretion on the other hand was significantly higher in the proximal cell vagotomy group than on the other vagotomy groups. The rate of gastric emptying in proximal cell vagotomy and anterior proximal cell vagotomy + posterior truncal vagotomy groups was delayed. The best results were found in the truncal vagotomy + pyloroplasty group when the gastric secretion and the rats of gastric emptying are concerned.

Animals↗