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Biomedical subjects

A Ciplea

Publications and source records attributed to A Ciplea.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Pattern of the cerebrospinal fluid (CSF) and blood biogenic amines and of the CSF, blood and urine amino acids as pathogenetic ground of the senile depressive illness.

A lot of over 60 atherosclerotics with clinical manifestations of senile depressive illness was studied comparatively with a lot of subjects of the same age with essential arterial hypertension (EAH). As concerns the behaviour of the catecholamine content in CSF and blood, the total catecholamines are approxiately equal in the two lots, but with a clear difference of the catecholamine fractions. The CSF catecholamines behaviour in old atherosclerotics is characterized by the presence of increased values of noradrenaline (NA) and of adrenaline (A), with increased statistical significance, but without modifications of the adrenaline percentage (A %) from the total catecholamines, comparatively to the values found in normal subjects. The serotonin (5-HT) content of the CSF in men with atherosclerotic senile depressive illness was lower even than in subjects with coronary atherosclerosis. In atherosclerosis protides modifications precede the histologic changes. In CSF, GLU, ALA, TYR increase in old subjects. In blood, GLU, ALA, TYR, HIS, LEU, SER increase in the same subjects. ARG decreases with age. THR is higher in men than in women. In the urine of all the men as well as of all the women of more than 60 years, GLN and ALA have increased values. LYS increases with age. GLN and ARG are higher in men than in women.

Aged↗
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Oligoelements in dog's chronic hepatitis and liver cirrhosis through dimethylnitrosamine.

By the emission spectrographic analysis, we have searched the following oligoelements: Mn, Cd, Cu, Be, Cr, Ge, Nb, Ga, Zr, W, Pb, Sn, As, Zn, Ag, Sb, Ni, Bi, Co, Mo, and V, in the aortic arterial blood, in the caval, portal and suprahepatic vein blood, in ascite and in the bile, in control and in intoxicated dogs with dimethylnitrosamine (DMNA). Be, Ge, Nb, Ga, W, As, Sb were never found. Increased values of Cu, Mn, Pb, Zn, Ni, Co, Mo and V were noticed. The differences between the values obtained at intoxicated dogs against the control dogs were sometimes clear; at other times they were equal. This is the case of Ag in the aortic and suprahepatic vein blood and in the bile. In the portal vein blood Zn exceeds almost two times the values obtained in the intoxicated dogs. Also in the portal vein blood, Mo is almost three times more in the control dogs than in the intoxicated ones. But, generally, the values of the controls are below those found by the intoxicated dogs.

Animals↗
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Experimental researches regarding the metabolic changes determined by the prolonged exposure to light or by keeping in darkness.

The authors conducted complex investigations in the domain of the intermediary metabolism under experimental conditions on 24 dogs grouped into three lots: lot A, twelve dogs, exposed for six months to the action of continuous light; lot B, six dogs, maintained in darkness; lot C, six dogs, maintained for the same period in the animal house, getting the same food as the other two lots, which are the control lot. We determined some biochemical, hematological, enzymatical parameters, before the beginning of the experiment, and after 24 hours, 48 hours, 7, 14 and 21 days, one, two, three, six months. Then the animals were sacrificed, and fragments from the aorta, coronary vessels, myocardium, brain, adrenals, pancreas and liver were examined both on the optical and on the electronic microscope and we analysed some fats from the vascular tissues. The net decrease of proteinemia with lot A was registered, concomitantly with a net decrease of serumalbumins, of the alpha 1-globulins and of the gamma-globulins, and with a rise of the alpha 2- and beta-globulins. The values of glycemia increased with lot A, and less with lot B. The thrombocytes decreased obviously with lot A, and less with lot B. GPT decreased with lot A, and GOT increased. The serum Zn decreased slowly with lot A, and more irregularly but more obviously with lot B. The serum Cu increased with lot A, and decreased with lot B. Alterations on the level of arterioles from the brain, aorta, myocardium and pancreas were evidenced, as well as electronmicroscopical alterations of the arteriolar walls and of the cellular organelles. The lipids from the brain, aorta and myocardium increased with both of the experimental lots and so did the cerebrosides, lecithins and the sphyngomyelin.

Adrenal Glands↗