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Biomedical subjects

A Clermont

Publications and source records attributed to A Clermont.

At least 19 recordsLinked to original sources
PubMed1996

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor.

The vascular complications of diabetes mellitus have been correlated with enhanced activation of protein kinase C (PKC). LY333531, a specific inhibitor of the beta isoform of PKC, was synthesized and was shown to be a competitive reversible inhibitor of PKC beta 1 and beta 2, with a half-maximal inhibitory constant of approximately 5 nM; this value was one-fiftieth of that for other PKC isoenzymes and one-thousandth of that for non-PKC kinases. When administered orally, LY333531 ameliorated the glomerular filtration rate, albumin excretion rate, and retinal circulation in diabetic rats in a dose-responsive manner, in parallel with its inhibition of PKC activities.

Administration, Oral↗
PubMed1994

Efficacy of loratadine versus placebo in the prophylactic treatment of seasonal allergic rhinitis.

The efficacy of loratadine as prophylactic therapy for seasonal allergic rhinitis was evaluated in a randomized, double-blind, parallel group, placebo-controlled study. One hundred eighteen subjects received either loratadine, 10 mg once daily, or placebo for 6 weeks. Treatment was begun prior to the onset of grass pollen seasonal symptoms of allergic rhinitis. Total symptom-free days occurred more frequently in subjects receiving loratadine. More loratadine than placebo subjects (65% versus 49%) had no symptoms or mild rhinitis at the end of the study. In contrast, the differences between loratadine and placebo in symptom scores did not achieve significance. The incidence of sedation and anticholinergic effects were comparable between the groups. Prophylactic loratadine therapy was effective in suppressing symptoms of seasonal allergic rhinitis and providing patients with symptom-free days throughout the pollen season.

Adolescent↗
PubMed1991

[Treatment of percutaneous angioplasty of restenoses of coarctation and stenosis of bioprostheses in children].

The authors discuss the percutaneous balloon dilatation procedure and the results obtained in 10 children (age range: 2.5-13 years) over a 2 year period (April 1986-April 1988). Six cases of coarctation restenosis were observed and good clinical and hemodynamic results were noted in 2 cases, while in 4 cases the procedure was not totally successful. For the 4 cases of stenosis of bioprosthetic valves in right ventricular-to-pulmonary arterial conduits, good results were obtained with a significant reduction of the trans-stenotic gradient from 50 to 23 mmHg. While long-term effectiveness of the procedure is still uncertain, those encouraging preliminary results suggest that this procedure could be considered as an alternative treatment for coarctation restenosis and stenosis of bioprosthetic valves in right ventricular to pulmonary artery conduits.

Adolescent↗
PubMed1991

[Treatment of congenital pulmonary valve stenosis by percutaneous valvuloplasty].

The purpose of this study was to evaluate the efficacy technique and follow-up results of balloon valvuloplasty for congenital valvular pulmonary stenosis. Percutaneous dilatation was performed in 48 patients aged 0.5 to 21 years (m = 7.5 yrs) from two pediatric cardiology centers (Lyon and Montreal). The right ventricular peak systolic pressure ranged from 42 to 180 mmHg (m = 93) before dilatation and fell from 24 to 105 mmHg (m = 48) immediately after dilatation. The pulmonary valvular peak systolic pressure gradient ranged from 22 to 156 mmHg (m = 73) and fell to 4 to 70 mmHg (m = 27) after the procedure (P less than 0.001). Follow-up continuous doppler data was available from 33 patients at 1 to 37 months (m = 9.2 months) after dilatation. The maximal instantaneous gradient from right ventricle pulmonary artery ranged from 0 to 74 mmHg (m = 27).

Adolescent↗
PubMed1988

[The concept of critical arterial stenosis: value of a model of measures obtained by an angiographic method and the Doppler technic before and after transluminal angioplasty of the iliac arteries].

INTRODUCTION: Numerous studies in the literature have proven the fact that a critical size appears during the stenosis evolution. The work presented is a non invasive approach of this value, with correlation to the invasive results. The study was realized on a homogeneous group of 23 arteriopathic patients, selected for iliac artery angioplasty procedure. MATERIAL AND METHODS: Patients selection: twenty-three patients including 24 angioplasty procedures have been selected on a 21 month time study. Invasive data: two measurements are realized during angioplasty: trans-stenotic pressure gradient before and after angioplasty. stenosis calibration: both diameter and section have been calculated on radiological films. Non invasive data: a standard Doppler test is performed on lower limbs. Two parameters are compared with the invasive data: the ascending time of velocity curve at the common femoral level. the systolic pressure index (peripheral pressure/radial pressure). RESULTS: 1) Critical stenosis--invasive techniques (fig. 1): trans-stenotic pressure gradient versus stenotic measurements shaw an hyperbolic correlation. The critical stenotic level is found to be 60% in diameter and 80% in section. 2) Critical stenosis--non invasive techniques: stenotic measurements compared to ascending time (fig. 2) as well as pressure index at rest (fig. 3) shaw the same type of curve. The critical stenotic level is found to be the same than with invasive techniques. DISCUSSION: Some discordant results open the discussion about angioplasty as a "gold standard", specially with a geometrical analysis. Bad precision in non regular stenosis. Hemodynamic consequences of turbulent stenosis are not evaluated. Clinical interest of critical stenotic notion is underlined.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1988

[Digital arteriography of the lower limbs by sequential, automatic table translation. Feasibility. Preliminary results].

Digital subtraction angiography (DSA) as a method of evaluating lower limb arteries required examination of one limb at a time up to now. Moreover repeated injections of contrast material were necessary. This problem was mainly due to the relative small image intensifier field available and to the difficulty of repositioning the patient between mask and image acquisition. The authors report the preliminary results obtained with 24 patients studied on angiographic unit equipped with: A DSA system (DG 300-CGR) using 512 X 512 matrix size, an angiographic table (Angix M 200) allowing an automatic sequential translation, a removable image intensifier using a 16 inch field below the table. Thus, all those characteristics allow DSA of lower limb arteries. Only one injection of contrast material (Ioxaglate: 80 ml at 8-10 ml/second) was used per procedure. This, usually, allows good quality examination of lower limb arteries.

Angiography↗
PubMed1987

Embolization of the systemic arteries of the lung.

Embolization of the systemic arteries of the lung (described by Remy and colleagues in 1973) is now a useful method for the treatment of hemoptysis or hemorrhagic lesions of the lung prior to surgical treatment, or for local treatment of hemoptysis when surgery is contraindicated or unnecessary. The technique is based on the anatomy of the different divisions of the systemic circulation (bronchial and extrabronchial), which for various physiologic reasons may develop hypervascularization. The results, complications, and contraindications of systemic embolization have previously been described and the technique is now commonly practiced.

Embolization, Therapeutic↗
PubMed1985

[Contribution of digital venous angiography to the evaluation of arterial hypertension. Cost evaluation].

Concerning 100 intravenous digital subtraction angiographies (IV DSA) performed for the study of arterial hypertension, the results are discussed according to two different achievements: diagnostic and economic. One hundred patients have been examined after the intravenous (IV) injection of contrast material, seventy times in peripheral and thirty times in central venous system. Out of 94 examinations that could be interpreted, 10 revealed stenosis of renal arteries higher than 50 per cent, one revealed fibromuscular dysplasia. IV DSA generally permits the correct study of renal arteries and compared to conventional angiography it gives only a small number of false negative results. However, the reliable study of intrarenal vascularisation can be obtained only by renal arteriography. The renal arteriography remains therefore necessary: when renal IV DSA gives insufficient data; to estimate the degree of stenosis in fibro-muscular dysplasia; to evaluate intrarenal vascularisation before renovascular surgery or angioplasty. To estimate the economic validity of renal IV DSA for the study of arterial hypertension, we have investigated: the actual cost of the examination for a department of radiology, compared with the cost of conventional examination; on the other hand, the influence of this examination on the duration of hospitalisation for evaluation of arterial hypertension. According to our investigation, this examination allows the average reduction of expenses for 180 F per patient with arterial hypertension, and shortens the time of hospitalisation for about one day. Owing to this diagnostic and economic contribution, renal IV DSA is becoming the first examination to be done for the evaluation of renovascular hypertension.

Angiography↗
PubMed1985

[Late post-traumatic hemoptysis caused by hypervascularization in the area of pulmonary hematomas. Apropos of a case].

The authors report a case of hemoptysis occurring after closed chest trauma complicated by spontaneously regressive parenchymatous hematomas. Bronchial arteriography showed systemic hypervascularisation with shunt in the territory of a hematoma which had regressed spontaneously several months previously. The authors mention the rarity of this aetiology and emphasise the value of bronchial arteriography and of embolisation.

Adult↗
PubMed1984

[Angiography in bypass grafts of the left anterior descending coronary artery with the left internal mammary artery. Apropos of 100 control examinations with a maximum follow-up of 6 years and 8 months].

Ninety three patients underwent 100 angiographic control studies of a left internal mammary artery bypass of the left anterior descending artery. The controls were carried out between 11 days and 6 years 8 months after surgery. Seven patients underwent two control studies. The patients were divided into three groups:--60 early control angiographic studies (before 2 years);--16 late control angiographic studies (between 2 and 5 years);--24 very late systematic control angiographic studies (after 5 years). The patency rate of the arterial grafts was 99%. From the anatomical point of view, the arterial walls of the internal mammary artery appeared smooth and regular except in one case. There was no cases of bypass graft disease. The ratio of the diameters of the internal mammary and left anterior descending arteries was greater than or equal to 1 in 93% of cases. The adaptation of the diameter of the internal mammary artery to that of the left anterior descending artery is an early phenomenon as shown by statistical and repeat control studies. The number of remaining collateral vessels does not appear to have an effect on the diameter of the internal mammary artery. Stenosis at the site of anastomosis was observed in 16% of cases. This seemed to be favoured when the angle subtended by the two vessels reached 90 degrees. The haemodynamic changes of the coronary circulation (competition of flow, competition of flow in the distal vessels, reflux in the internal mammary graft) were comparable to those observed in aorto-coronary saphenous vein bypass.

Adult↗