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Biomedical subjects

A Cliff

Publications and source records attributed to A Cliff.

4 recordsLinked to original sources

Surgeon-controlled ultrasound-guided core biopsies in the breast--a prospective study and a new use for surgeons in the clinic.

AIMS: This study was to assess the accuracy of a surgeon performing ultrasound-guided core biopsies of the breast. METHODS: A prospective audit was carried out of 555 patients who underwent an ultrasound-guided core biopsy for a discrete solid mass [under 30 mm maximum diameter] by a single surgeon. The surgeon controlled the core biopsy needle and an ultrasonographer or radiologist provided the imaging with ultrasound. RESULTS: The accuracy of the surgeon in sampling the lesions [n = 555 core biopsies] was independent of the size of the lesion. This saved 272 patients having unnecessary surgery for a benign lesion. CONCLUSION: The practical involvement by the surgeon in breast ultrasound and performing core biopsies has reduced pressure on the breast radiologists, reduced the number of diagnostic surgical open biopsies and made the clinic more interesting for the surgeon. With increased surgical confidence in breast ultrasound, most small and impalpable cancers have pre-operative skin marking rather than X-ray wire localization prior to undergoing wide local excision. Trainee breast surgeons should be encouraged to learn breast ultrasound and core biopsies.

Adult↗

The spread of human immunodeficiency virus type 2 into Europe: a geographical analysis.

Geographically-related computer databases on the global incidence of HIV-1 and HIV-2 infection are being maintained in the Department of Geography at the University of Cambridge, England. Using the information they contain, the original geographical heartlands of HIV-2 infection are identified as former Portuguese and French colonies in West and South Central Africa. The same databases permit the reconstruction of the diffusion corridors by which the virus is spreading from these heartlands into Europe. The reconstruction shows that, as a result of traditional links with their former colonies, the main areas of infection in Europe are Portugal and France. These countries have subsequently acted as diffusion nodes for the spread of the virus to other parts of Europe. The patterns of spread thus differ fundamentally from those by which HIV-1 infection arrived in and is moving through Europe.

Acquired Immunodeficiency Syndrome↗

Island epidemics.

Explore the source record for details and available documents.

Disease Outbreaks↗

Methods for the measurement of epidemic velocity from time-series data.

Two approaches to the measurement of epidemic velocity are presented. The first uses the moments of the frequency distribution of reported cases of a disease against time. The second is based upon an analysis of the growth parameter of a logistic model. The methods are illustrated by applications to some hypothetical and actual epidemic waves.

Disease Outbreaks↗