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Biomedical subjects

A Coli

Publications and source records attributed to A Coli.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Australia antigen in diabetic subjects.

The sera of 766 diabetics and 730 blood donors have been tested for Australia surface antigen (HBsAg). Subjects with a history of an episode of jaundice were excluded from both groups. The two groups did not differ as to the frequency with which HBsAg was found 1.64% in blood donors, 1.56% in diabetics.

Aged↗
PubMedDate not supplied

The spinal cord development in guinea pig: a morphometric study on an image analysis system.

Using an image analysis system, the Authors carried out a morphometric study on guinea pig spinal cord in order to determine volumetric changes of white and gray matter during development. White and gray matter volumes were determined by measuring the area occupied by these matters in 10 micrograms sections of spinal cord in 1 day and 90 days old subjects. Several topographic correspondences in the localisation of the lowest and highest volumetric values were observed in the two groups of subjects. Such correspondences were more marked for white than gray matter. Moreover, during growth white matter volume showed an increase double that observed in gray matter.

Animals↗
PubMedDate not supplied

Gastric syphilis simulating malignant lymphoma.

We report a case of syphilis of the stomach, occurring in a 50 year old man, which simulated malignant lymphoma microscopically and had also the endoscopic appearance of a malignancy. To the best of our knowledge this is the first report of gastric syphilis mimicking a lymphoma, and we believe that the recognition of this presentation is of particular importance to correctly set the disorder especially for therapeutic purposes and in order to avoid unnecessary surgery.

Biopsy↗
PubMedDate not supplied

Analytical and clinical assessment of a commercial kit for the simultaneous determination of free thyroxine and thyrotropin.

The SimulTRAC FT4/TSH kit (Becton Dickinson), allowing a simultaneous determination of free thyroxine (FT4) and thyrotropin (TSH), was assessed in terms of analytical quality and clinical performance. The results of a multicenter trial were included in this study to obtain a more complete and reliable information. The current validation procedures (ie evaluation of analytical imprecision and sensitivity, between-kit comparison of estimates and--limited to TSH--check of response linearity on dilution) demonstrated quite acceptable analytical characteristics for both the FT4 and the TSH tests. The diagnostic sensitivity and predictive value were derived for separate and combined tests from a relatively large number of cases (ie 401 euthyroids, 127 overt and 48 subclinical hypothyroids, 205 overt and 80 compensated hyperthyroids). The TSH test proved more effective than FT4 in discriminating both overt and subclinical dysfunctions, and, in this respect, the test association was found to add a little advantage--if any. However, the extension of the concepts of diagnostic efficiency to any combination of test results--favoured by their production in a single assay--provides a basis to establish diagnostic protocols and to predict costs and benefits of medical actions.

Evaluation Studies as Topic↗
PubMedDate not supplied

Langerhans cell and HLA class II molecules distribution in lung carcinoma.

We have evaluated Langerhans cell (LC) distribution in 19 lung carcinomas and 1 carcinoid tumor, furthermore investigating HLA class II molecules expression by the neoplastic cells; this was done using, in immunohistochemical tests, a polyclonal antiserum anti S-100 protein for the identification of LCs and a mouse Monoclonal Antibody (MoAb) for the detection of HLA class II -DR molecules. Our results indicate that LCs are poorly represented in lung carcinomas and likewise HLA class II molecules are scarcely expressed by the neoplastic cells; this might be important in understanding the ominous prognosis of lung carcinomas since both parameters investigated play a central role in the immune response against human neoplasia, LCs as antigen presenting cells and HLA class II molecule as restriction elements during antigen stimulation of CD4+ T lymphocytes.

HLA-DR Antigens↗
PubMedDate not supplied

[Stress myocardial scintigraphy in the pre- and postoperative diagnosis of ischemic cardiopathy. The correlations between the clinical aspects and the coronary angiographic picture].

With radioisotopes it is possible to study the heart obtaining complementary or substitutive informations to those provided by the most common noninvasive methods of myocardial assessment and by coronarography. This paper aim is to report experience with thallium 201 and 99mTc isonitrile in the diagnosis and followup of ischemic heart disease, in particular correlating clinical, coronarographic and scintigraphic findings. MATERIAL AND METHODS. During the biennium 1989-91 we have used the myocardial perfusion imaging with thallium 201 in 29 patients (20 male age ranging from 40 to 60 years) injecting 2 mCi at exercise peak with immediate planar mapping, followed by a second registration at rest 4 hours later (thallium 201). Imaging with 99mTc SESTAMIBI has been carried out in 6 patients (two of whom previously studied with thallium 201) injecting 20-22 mCi both at stress peak and at rest, with SPECT mapping 60'-90' later. All these patients presented specific problems for the diagnosis of myocardial ischemia. The exercise testing has been performed by a bicycle ergometer and with a standardized procedure increasing every two minutes the workload to the maximum tolerated according to the clinical conditions and to the response. All antianginal treatments were discontinued for at least 48 hours before testing and the patients were fasted for 6 hours. The images were obtained using a small field scintillation camera with a low-energy general purpose collimator. We divided the patients in 4 groups: Group A. Six patients who had an open heart operation: in 5 coronary revascularization was carried out (plus left ventricular aneurysmectomy in one and plus aortic valve replacement in another); in 1 patient an aortic valve replacement was performed on. Group B. Six patients have been evaluated after coronary angiography. Group C. Seventeen patients with doubtful diagnosis of myocardial ischemia on the base of the symptoms and/or non invasive testing as rest or stress electrocardiogram (ECG). Group D. In 6 more patients (2 of those previously studied with thallium 201) the myocardium has been assessed with SESTAMIBI. RESULTS. In one patient of the group A the thallium 201 images detected silent ischemia; in 5 removed the diagnostic doubts of the ECG findings owing to left ventricular overload or to old infarctions in 2 patients and to electrolytes disturbances or pharmacological effects in 3 patients. In group B patients the thallium 201 further on could assess the extent of ischemic and necrotic areas suggesting the final indications to angioplasty in 3 patients, medical treatment in 2 and surgery in 1. We could not find correlations between the extent of the disease predicted by the coronarography and the findings of the thallium 201 images. In the diagnosis of myocardial ischemia, group C, the Thallium 201 has been very useful and specific excluding an ischemic origin in 4 patients with arrhythmias, in 2 patients without symptoms of angina but with doubts at rest and exercise ECG findings and in 4 with atypical thoracoalgia and doubtful ECG. On the contrary, this test could give the final diagnosis of ischemia in 6 patients displaying its sensitivity in detecting coronary artery disease. Among the patients assessed with SESTAMIBI, in 2 this test has been essential in evaluating the myocardial contractility and the segmental wall motion. DISCUSSION. The usefulness of Thallium 201 imaging, as a very sensitive mean in detecting coronary artery disease and in the assessment of myocardial viability, is well known. Although the most common indications of this technique are well standardized, in the clinical practice there are many situations in which the thallium 201 can contribute to the diagnosis and to the management. (ABSTRACT TRUNCATED)

Adult↗