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Biomedical subjects

A Colignon

Publications and source records attributed to A Colignon.

5 recordsLinked to original sources
PubMed1989

Upper extremity function after conservative interscapulo-thoracic tumor resection.

Six patients who had undergone an en bloc interscapulo-thoracic excision (for primary bone or soft tissue sarcoma in five, and metastatic disease in one) were subject to review, with special emphasis on the functional outcome of the operated arm. Active shoulder motion was poor in all patients, but this did not prevent passive positioning of the hand and elbow. Elbow and particularly hand function was either not, or only slightly, impaired so that two patients regained full use of their upper extremity. Three patients had satisfactory but impaired function and one with metastatic disease of the should had a poor functional outcome.

Adult↗
PubMed1984

Preparation and experimentation of an antidigitalin monoclonal antibody: interest in human treatment.

A monoclonal antidigitalin antibody was obtained following the immunization of BALB/mice with digitalin coupled to BSA, and the fusion of lymphocytes from these mice with murin myeloma 8653. The supernatants were screened by a radioimmunoassay in which the supernatant was incubated with digitalin coupled to I125. This monoclonal antibody "Dig 278" has an antigen binding ratio of 95%; is an IgGl; has a titre of 1/1000 and its affinity constant, as determined by a Scatchard plot, was 1,20(9) L/M. By experimenting with the monoclonal antibodies on 15 rabbits, we have obtained the reversal of heart rhythm disorders and the survival of animals injected with a lethal dose of digitalin. All the controls died. This antibody could prove useful in treating advanced cases of digitalin intoxication and for which no satisfactory treatment is available at present.

Animals↗
PubMed1982

[Production of an anti-digitalin monoclonal antibody (author's transl)].

Anti-digitalin monoclonal antibodies were obtained by hybridization of lymphoid cells from mice immunized with the drug and the 8653 myeloma cells from BALB/c Mice. Two of these antibodies were submitted to immunochemical analysis which revealed that they belonged to IgM and IgGl classes, and the high affinity of one of them (1,2 x 10(9) M(-1)). The availability os such antibodies opens new perspectives for the treatment of digitalin intoxication and the possibility of establishing a standardized radioimmunoassay.

Animals↗