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Biomedical subjects

A Constantinescu

Publications and source records attributed to A Constantinescu.

At least 19 recordsLinked to original sources
PubMed1992

Recombinant antibody-metallothionein: design and evaluation for radioimmunoimaging.

We have produced a chimeric antibody (Ab) in which metallothionein, a well-characterized biological chelator of metals, was genetically fused to the F(ab') domain of the S107 Ab heavy chain. Coexpression with the Ab light chain that conveys specificity for the synthetic antigen phosphocholine was achieved in plasmacytoma cells. Metal- and antigen-binding domains of the Ab-metallothionein hybrid function with normal avidity and specificity. Ab-metallothionein can be efficiently loaded with 99mTc and used to specifically bind phosphocholine-haptenated cells in vitro or to localize plasma-cell ascites tumors in mice. The approach offers potential advantages for producing radiolabeled Ab for targeted radiotherapy and diagnostic imaging.

Animals↗
PubMed1992

Synthesis and evaluation of technetium-99m monocationic mixed ligand complexes of phenyl substituted/condensed tetradentate Schiff's bases and trimethylphosphine.

Tc-99m monocationic mixed ligand complexes of phenyl substituted/condensed Schiff's bases, N,N'-ethylene-bis-(benzoylacetone imine) (Lb) or N,N'-ethylene-bis-(salicylaldehyde imine) (Lc) or N,N'-ethylene-bis-(2-hydroxyacetophenone imine) (Ld) and trimethylphosphine were synthesized to determine the influence of the presence of a phenyl group in these tracers on their heart uptake in rats. A new formulation procedure using aq. beta-hydroxypropylcyclodextrin (HPB) solution was developed for intravenous administration of nonpolar 99mTc complexes. Comparison of biodistribution data for the reference 99mTc complex from N,N'-ethylene-bis-(acetylacetone imine) and trimethylphosphine using HPB formulation and alternate formulation (0.9% saline) showed the same results. Biodistribution of the title 99mTc complexes, [99mTc Lb (PMe3)2]+, [99mTc Lc (PMe3)2]+ and [99mTc Ld (PMe3)2]+ showed heart-to-blood activity ratios of 1.7, 2.1 and 1.7, respectively, at 15 min post-injection in rats.

2-Hydroxypropyl-beta-cyclodextrin↗
PubMed1977

Spinal dissemination following operation on cerebral oligodendroglioma.

This paper concerns two cases of cerebral oligodendroglioma (intraventricular in one case, right temporal in the other), with spinal dissemination (cervical and upper thoracic respectively), manifested clinically 2 years and 14 months respectively after removal of the cerebral tumour. Anatomical examination confirmed the diagnosis of disseminated oligodendroglioma in the leptomeninges in both cases and also in the parenchyma in the second case.

Adult↗
PubMed1977

Haematological aspects of hypophyseal tumours.

This paper is devoted to the study of anaemia in patients with hypophyseal tumours. Anaemia with a red blood cell count of 2.4 million/mm3 to 3.9 million/mm3 was found in 60 of 280 patients (21.7%) with hypophyseal tumours; 52 of the 60 patients were operated on. Similar changes were observed in 25 of 60 cases (41.7%) of craniopharyngioma. Apart from anaemia and a low haemoglobin some of the patients also had anisocytosis, anisochromia, leucocytosis, and haemolytic shock.

Adolescent↗
PubMed1977

Spinal dermoid tumours.

The present work is a detailed analysis of 12 cases of spinal dermoid tumours operated on between 1935 and 1976. Of these 11 were medullary (3 intramedullary and 8 subdural extramedullary), representing an incidence of 0-80% of medullary tumours, and 1 was an extraspinal coccygeal tumour. Most of the tumours were located in the spinal canal and conus. Good results were obtained following total ablation in 7 cases and partial removal of the tumour in 5 cases.

Adolescent↗
PubMed1977

Cranial eosinophilic granuloma.

Investigations were carried out on 27 cases of cranial eosinophilic granuloma: 16 males (59%) and 11 females (41%). The mean age was 25 years, the extremes being 2 years and 65 years. The location in 21 cases (80%) was exclusively in the calvarium (9 frontal, 8 parietal, three occipital and 1 temporal), orbital in two cases, fronto-orbital one case, base of the skull in the left parasellar region one case, left frontal subdural with chronic subdural haematoma one case and one case left occipital and petrosal bone. All the cases were diagnosed histologically. In 18 cases the tumour was removed at operation. Recurrences occurred in four of these cases (15%), three of whom died (11-5%). Four of the patients received steroid therapy and four steroid therapy combined with X-ray therapy. The evolution was favourable in all these cases.

Adolescent↗
PubMed1976

Supratentorial dissemination of medulloblastomas.

The present paper reports on 13 cases of medulloblastoma with supratentorial dissemination. With reference of these cases the authors discuss the pathogenetic probabilities of the dissemination of brain tumors, their evidence and treatment, emphasizing the importance of cerebral scintigraphy formed periodically in all patients previously operated of medulloblastoma. When dissemination is detected radiotherapy may give good results. If the symptomatology is very accentuated the secondary supratentorial tumour has to be removed.

Adolescent↗
PubMed1975

Neurinomas of the trigeminal nerve.

Neurinomas of the trigeminal nerve are rare tumours. Six cases of a series of 8,894 intracranial tumours operated upon in the Neurosurgical Clinic of Bucharest are reported. The literature is reviewed. One hundred one other cases have been found. The signs and symptoms produced by these tumours, their slow development, the radiological and other diagnostic findings, the treatment and the prognosis are discussed.

Adult↗
PubMedDate not supplied

Cranial and orbital epidermoid tumours.

This paper reports on 14 cases of cranial and orbital epidermoid tumours, of which 2 epicranial, 4 extradural intracranial, 4 fronto-orbital-sinusal, 2 orbital and 2 orbito-nasal cases. Referring to these cases and data published in the specialised literature, the authors show that this type of tumour is more frequent in males, and is generally of embryologic but very rarely of mechanical origin. The main symptom is tumefaction in cranial tumours and exophthalmos in orbital tumours. There is very rarely association with a space-occupying process (tumour, cerebral abscess). Evolution is slow and progressive; the only treatment is surgical. After total ablation there were no recurrences and the postoperative course was very satisfactory.

Adolescent↗
PubMedDate not supplied

[Clinical and hormonal development of a case of malignant exophthalmus after hypophyseal myskiotomy].

A pituitary myskiotomy was performed in a 26-years old man with Graves' disease and progressive exophtalmus. At the onset of Graves' disease a high level of serum TSH, LATS and thyroid hormones was found. Following pituitary miskiotomy a stationary exophtalmus and other signs of Graves' disease have been recorded. The serum levels of LATS and thyroid hormones were high. The serum concentration of TSH decreased to a level undetectable even after the TRH stimulation test. It is discussed the pathogenesis of Graves' disease: its onset due to neuroendocrine disturbances (S. M. Milcu) and its evolution due to autoimmune mechanisms.

Adult↗