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A Constantinovici

Publications and source records attributed to A Constantinovici.

76 records · Page 5Linked to original sources
PubMedDate not supplied

Hormonal evidence for the dissemination through the cerebrospinal fluid, of secreting cells from invasive pituitary adenomas.

In 13 patients with invasive pituitary adenomas submitted to pituitary surgery (5 HGH-secreting adenomas, 6 prolactin-secreting adenomas, 2 non-secreting adenomas), the concentrations of HGH and prolactin (PRL) constantly decreased after operation both in the cerebrospinal fluid (CSF) and serum, and the CSF/serum ratio remained under one, with few exceptions. These last cases (2 with acromegaly, 2 with invasive prolactinomas), showed an increase of HGH or PRL concentrations in CSF when serum levels decreased; the CSF/serum ratio rose above one within 2 weeks post surgery in 2 patients, and within 2 years post surgery in another two. The circulation of CSF was not obstructed. This indicated the appearance of a new, extrapituitary source for secreting HGH or PRL directly into the CSF, a source which most probably developed through the dissemination, via CSF, of secreting cells from malignant pituitary adenomas.

Acromegaly↗
PubMedDate not supplied

Abnormal somatosensory evoked potentials in amyotrophic lateral sclerosis.

The sensory symptoms and the involvement of the sensory tracts in amyotrophic lateral sclerosis (ALS) were much debated by various authors. The SEPs were studied in 10 patients with ALS by percutaneous stimulation of the median and tibial nerves. The SEPs were recorded at: Erb's point, cervical level (CII), lumbar level (L1) and parietal level. The peripheral sensory and motor nerve conduction were normal, excluding the spondylotic origin of altered SEPs found in these patients. There were 9 patients with abnormal parietal SEPs to the tibial nerve stimulation, usually bilateral. Abnormal cervical potential (N13) to the median stimulation was noted in 7 cases of whom 3 had also abnormal parietal SEPs. The most severe abnormalities were obtained in the 5 patients with fast advancing ALS and notably to the tibial nerve stimulation. Our results confirm the findings of other authors and reflect physiological dysfunction in the sensory system in a disease considered so far as restricted to the motor system.

Amyotrophic Lateral Sclerosis↗