PubMed Health⌕ Search

Biomedical subjects

A Cornejo

Publications and source records attributed to A Cornejo.

7 recordsLinked to original sources
PubMed2000

[Survival of patients with esophageal cancer subjected to total thoracic esophagectomy].

BACKGROUND: Esophageal carcinoma has a dismal prognosis. Several authors have reported a very low survival in Chile. AIM: To report the survival of patients with esophageal carcinoma, subjected to esophageal resection. MATERIAL AND METHODS: Analysis of 108 patients subjected to thoracic esophageal resection between 1985 and 1996. Patients were classified according to the location of the tumor and its staging. RESULTS: Eleven patients died in the immediate postoperative period and 90 patients were followed. In 53 the exact cause of death was determined. Global five years survival was 29% and median survival was 18 months. Survival was 100% in stage I tumors. Adjuvant therapy resulted in a better survival of stage III tumors. Survival of stage IV tumors was worst than stage I to III tumors. There was no survival difference between squamous carcinoma or adenocarcinoma. Tumors located in the superior third of the esophagus had a worst prognosis. Causes of death were mediastinic metastases, local recidivism, pleural or pulmonary metastases and less frequently, brain, bronchial or bone metastases. CONCLUSIONS: The survival of these, patients with esophageal carcinoma did not differ from the figures reported abroad.

Adenocarcinoma↗
PubMed1990

Degenerative ultrastructural changes observed in the neuropil of caudate nuclei from Parkinson's disease patients.

Degenerative changes of the pars compacta of the substantia nigra are considered the main physiopathological basis of Parkinson's disease, while most authors believe that the neostriatum is well preserved in these cases. This paper deals with the preliminary ultrastructural observations made in the neuropil of the caudate nucleus of Parkinson's disease patients. We have observed (1) astrocytic proliferation, neuronal degeneration, degenerated axons, and hyperdense postsynaptic neurites (dendrites), and (2) that degenerative patterns vary from one case to another. Physiopathological and therapeutical implications are discussed.

Axons↗
PubMed1990

Multidisciplinary analysis of the effectiveness of autologous neural transplant (adrenal medulla) as treatment of Parkinson's disease.

The neurobiological aspects of human neural transplants are far from being understood. We have approached their study by means of a multidisciplinary working team. Nine patients with Parkinson's disease were subjected to open brain surgery for grafting of autologous adrenal medulla. Not all patients improved. Those patients that did so showed different patterns of improvement. Rigidity was the sign most relieved in this group of patients. Electroencephalographic changes were attributable to surgical manipulation. High-performance liquid chromatographic quantification of catecholaminergic metabolites did not correlate with post-grafting outcome. Biopterin levels showed a significant increment after surgery. More interdisciplinary studies ought to be done on neural transplants.

Adrenal Medulla↗
PubMedDate not supplied

Cardiac arrhythmias in experimental subarachnoid hemorrhage.

Experimental subarachnoid hemorrhage (SAH) in dogs was produced by introducing blood into the subarachnoid space through a catheter connected to an artery of the animal. The intact animals and those with preserved vagi and heart sympathetic innervation, developed arrhythmias with short latencies which correlated with the sudden increase in the intracranial pressure. The animals with sections of both vagi and heart sympathetic innervation, but with an intact spinal cord, developed arrhythmias that were delayed and did not correlate with the changes in intracranial pressure. These arrhythmias were preceded by changes in the QT interval, T wave and ST segment. It was concluded that the arrhythmias could be produced either by direct autonomic discharges to the heart or by increased circulating and tissue catecholamines. The clinical implications of these findings are discussed.

Animals↗
PubMedDate not supplied

[Natural history of viral hepatitis A in Chilean adults: clinical and laboratory aspects].

In many countries, Hepatitis is mainly due to virus. A. When improving life condition in a given population, initially there is a tendency to increase the number of cases in adults. We report clinical and laboratory findings in 87 adults with acute viral Hepatitis A in Chile. The rate man/woman was 1.55/1. Mean age: 23.8 years. Clinical forms: icteric classical (77.01%), cholestatic (10.34%), anicteric (8.05%), biphasic (2.30%) and fulminant (2.30%). From 87 patients in consult 1, 64 were controlled at day 15 (consult 2) and 35 one year later (consult 3). Laboratory (means): ALT (UI/L): 856.8, 111.6 and 20.8 in consult 1, 2 and 3 respectively. Correlation between values of ALT and AST (p < 0.0001). Mean total bilirubin (mg%): 6.6, 2.5 and 0.8 respectively. The evolution of Hepatitis A was favorable with a rapid decrease of clinical signs and normalization of laboratory values within the 3 first weeks of disease.

Adolescent↗