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Biomedical subjects

A Corrias

Publications and source records attributed to A Corrias.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Growth hormone treatment in irradiated children with brain tumors.

We assessed the efficacy of GH treatment in 25 GH deficient patients irradiated for brain tumors (eight with glioma cranio-irradiated, eleven with medulloblastoma and six with ependymoma craniospinal-irradiated). We administered GH at doses of 0.6-0.9 IU/kg/week for one to three years at least two years after diagnosis of the tumor. We assessed the efficacy of the treatment each year by comparing the values of height velocity over bone age and change in the ratios progression of chronological age/progression of bone age and progression of statural age/progression of bone age. The treatment promoted satisfactory growth; better results were obtained in patients with glioma, who received cranial irradiation only, than in those with medulloblastoma or ependymoma, who received spinal irradiation as well. Moreover, the growth prognosis improved, especially in the cranio-irradiated patients. In our series of patients four presented tumor recurrence; these results did not differ significantly from those in irradiated patients with cerebral tumors who were not treated with GH.

Adolescent↗
PubMedDate not supplied

Patients with Hashimoto's disease treated with L-thyroxine and followed for three years.

This study investigated the effectiveness of L-thyroxine management in 32 patients (mean age 11 years and 2 months; M:F = 1:5) with Hashimoto's disease followed annually for 3 years. One (8%) of the 12 patients, euthyroid at the onset, never required treatment; of the four (33%) who began treatment immediately, two were able to stop at the 1st or 2nd follow-up, whereas two had to continue. The other seven (59%) who did not begin treatment immediately had to start at the 1st, 2nd or 3rd follow-up. The findings in this small series suggest that hormone management may prove effective to a certain extent in euthyroid Hashimoto patients, primarily as a means of prevention.

Adolescent↗
PubMedDate not supplied

Factors at onset predictive of lasting remission in pediatric patients with Graves' disease followed for at least three years.

Seventeen pediatric patients (mean age at diagnosis 10 yr and 9 mo +/- 2 yr and 9 mo) with Graves' disease treated with 0.3-0.7 mg/kg/day methimazole and followed for at least three years, during which drug suspension was attempted on attainment of good clinical and metabolic compensation, were retrospectively studied to look for factors predictive of lasting remission present at onset. Lasting remission was defined as a clinical and laboratory picture of euthyroidism lasting at least one year in the absence of treatment at the end of the follow-up. A distinction was drawn between patients who reached remission after one or two courses (groups 1 and 2) and those who never attained a lasting remission (group 3). TRAb (TBIAb) levels at onset were the only factor significantly correlated with the response to treatment. Age at diagnosis, goiter size and fT3 and fT4 concentrations were not significantly correlated with the clinical picture. The series was too small to allow any assessment of the real importance of these factors, though a generally better response was displayed by children over 11 years old, without appreciable or with very small goiter and moderately increased thyroid hormone levels at onset (fT3 < 25 pg/ml in 10/10 in groups 1 and 2 and 2/7 in group 3 patients; fT4 < 40 pg/ml in 7/10 in groups 1 and 2 and 3/7 in group 3 patients). It was also found that better results were obtained when the initial drug course was protracted for at least two years.

Adolescent↗
PubMedDate not supplied

[Empyema due to an anaerobic Streptococcus in childhood].

Anaerobic infections are quite rare in pediatric age, being that, they affect only neonates and immunodepressed patients. We think to be somewhat interesting to describe the case of our patient, a 9 year old boy, unaffected by any predisposing factor, came under our observation because of a severe respiratory distress. He showed evident clinical and radiological signs of pleural effusion in the right lung, together with a gas coil in the upper field and a left mediastinal shifting. A thoracentesis was then performed, giving rise to 600 ml of foul smelling purulent material; this procedure promptly improved his respiratory function. A permanent drainage trough the chest wall was set and an antibiotic therapy, based on the clinical picture and the character of the exudate, begun. In effect, the typical smell of the purulent material led us to suspect an anaerobic infection, and for this reason we employed the teicoplanin iv, a rarely used in the pediatric age drug. While blood cultures were negative for any organism, exudate cultures yielded Peptostreptococcus anaerobius; the last one resulted highly sensible following antibiogram to the previously chosen drug. The x-ray pattern and the rapid disappearing of the gas coil induced us to exclude further either congenital or acquired lung diseases. We conclude that, in absence of other proved sources of entry, the air presence in the pleural space was secondary to gas formation by the anaerobic micro-organism. The clinical course was very satisfactory allowing the patient to be dismissed on the 28th hospital day, with no need of further surgical therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

Child↗
PubMedDate not supplied

[Nedocromil in the treatment of chronic asthma in children. A double-blind vs placebo study].

After 2 weeks of observation, Nedocromil has been studied in double blind vs placebo for 8 weeks in 40 children with asthma of medium seriousness. Patients had to record on a clinical diary symptoms (wheezing and cough), beta 2-agonists consumption and collateral effects of the drug. Every 2 weeks patients had a clinical examination and the physician's judgement about the treatment's efficiency was registered. Patients who took the active drug had an improvement in symptoms from the 3rd week of observation and a significative decrease in bronchodilators' consumption. The judgement about the treatment's efficiency was different between physician and patients thus preventing the recognition of the patients who had taken Nedocromil from those who had taken placebo. We think that the different consumption of beta 2-agonists could be the reason for this behaviour between the 2 groups.

Adolescent↗
PubMedDate not supplied

[Effectiveness of a new beta 2-agonist (broxaterol) on bronchospasm induced by methacholine (blind study versus salbutamol)].

A new beta 2-agonists, broxaterol, administered by oral spray has been tested to evaluate its action modifying on the bronchial hyperreactivity to metacholine. Such drug has been administered double blind Vs salbutamol individualizing for both, at 15' and 90' premedication the PD20 FEV1 (doses of metacholine necessary to reduce of 20% the FEV1). The results that we have obtained confirm the protective capacity for both drugs on the bronchoconstriction induced by aspecific stimulus. However, in confront with salbutamol, the broxaterol presents an action more lasting in the time. Such requisite and absence of collateral effects permit to affirm that this new beta 2-agonists is fit for its utilization in the infantile intrinsic asthma.

Adrenergic beta-Agonists↗
PubMedDate not supplied

[Efficacy of broxaterol (vs salbutamol) in asthma induced by physical exercise in children].

B2-agonists play a first-rate role in the exercise induced asthma (EIA) prevention for their capacity to modulate the bronchial tone. We studied the efficacy of a new B-sympathomimetic (Broxaterol) in 10 children (7 males and 3 females) with EIA in double blind vs salbutamol. During two consecutive days a basal treadmill incremental exercise test was made for determining bronchoconstriction rate (IB). Subsequently the test was repeated 30' and 150' after the drug's administration. The Broxaterol premedication determined, by comparison with the basal IB value, a mean difference of 11.9 after 30' (p less than 0.05) and 10.0 after 150' (p less than 0.01). No significant correlation was found comparing the salbutamol premedication. In conclusion our data confirms the Broxaterol efficacy in exercise-induced asthma prevention.

Adolescent↗
PubMedDate not supplied

[Clinical effectiveness of a new preparation of sustained-release theophylline].

Twenty pediatric patients, age range 7-13 years, affected by asthma, have been treated with a sustained release preparation of theophylline once daily (mean dosage 13 mg/kg). The findings of plasma levels of theophylline below therapeutic range twenty four hours after dosing, in steady-state conditions, underline the need of individualized therapy specially in pediatric patients. The Authors observed a good therapeutic effect of this sustained release preparation, as expressed by improvement of symptomatology and pulmonary function tests, together with the sparing effect on other drugs. No side effects have been observed.

Adolescent↗
PubMedDate not supplied

[Acute disseminated histiocytosis X. Presentation of a case].

The AA. report a case of acute, diffuse histiocytosis X with an unfavourable course observed in a child of 33 months. The histological diagnosis, formulated on the basis of specimen taken from a skin nodule, was confirmed by ultrastructural observation of Birbeck bodies in the cytoplasm of proliferating Langerhans cells.

Acute Disease↗
PubMedDate not supplied

[Beta 2 stimulants in the therapy of childhood asthma].

Bronchial obstruction, chronic or acute, is due to different anatomical and functional events, mainly to smooth muscular contraction and oedema and secretions. In the first age of life the secretions and thickness of bronchial wool are the most important factors due to small bronchial caliber and poor muscular component. In the older child the most important cause is determined by the reactive spasm of bronchial smooth muscle.

Administration, Oral↗
PubMedDate not supplied

[Procaterol in the prevention of recurrent asthmatic bronchitis. Double-blind study].

In a study in double-blind it has considered if the procaterol, given for a month, had been able to develop a preventive action in children affected from relapsing asthmatic bronchitis. For that the clinical symptomatology, the number of the contagious events and the consumption of the drugs have been valued for two following months. The patients who had taken the procaterol, presented a reduction of the contagious events, of the consumption of the drugs and of the spastic bronchus symptomatology in the first month of the treatment which continued in the second month. In spite of the development of the contagious events, in the third month, the pulmonary symptomatology resulted inferior in comparison with the group of check. It is likely than the treatment with procaterol avoids the arisen of the spastic-bronchus symptomatology for a rise of the threshold of bronchial re-established, consequent to the re-establishment of the mucous lesions.

Adrenergic beta-Agonists↗
PubMedDate not supplied

[Opsoclonic encephalopathy in childhood (Kinsbourne syndrome)].

Kinsbourne's syndrome (ataxia--opsoclonus--myoclonus) is described. The characteristics of this syndrome are: infections of the upper respiratory tract and enteric system and behavioural disturbances leading to the typical symptomatological triad. Various tests were carried out to determine the presence of neuroblastoma which is often associated (46%) to this syndrome. These tests resulted negative. Differential diagnosis was considered in relation to other conditions which present a characteristic symptomatology similar to Kinsbourne's syndrome. Synthetic ACTH (Synacthen) treatment produced a regression of the clinical symptoms. Based on the examinations carried out, which always resulted negative even after 36 months, and on the drug dependence, the present case was diagnosed as primitive opsoclonus.

Ataxia↗
PubMedDate not supplied

[Aspects and behavior of x-ray computed tomographic studies in subacute sclerosing panencephalitis].

The authors reports cerebral Computerized Axial Tomography findings examined, in association with other diagnostic tests, in 5 cases of Subacute Sclerosing Panencephalitis in the acute phase and repeated in 2 of these patients later, during the state and terminal phases of the disease. Hypodensity of the white matter was the main sign of initial cerebral parenchymal involvement and an atrophic aspect was most indicative of the terminal phase. Moreover, it has been shown that associated with clinical symptomatology, immunologic data and EEG signs, cerebral Computerized Axial Tomography may offer the possibility for evaluating the nature and the evolutive stage of the disease and facilitate differential diagnosis from other degenerative encephalopathies.

Child↗