Biomedical subjects

A Cutando

Publications and source records attributed to A Cutando.

5 recordsLinked to original sources

PubMed2000

Oral health management implications in patients with tuberous sclerosis.

We report 6 cases of patients with tuberous sclerosis and concomitant dental pathosis. The multiple manifestations in tuberous sclerosis determine its impact on dental therapy. A lack of awareness of this condition may compound the possible side effects of dental treatment. Possible preventive measures by dentists are highlighted in this presentation. Medical evaluation and the control of risk factors in relation to general anesthesia and sedation are key considerations for the management of patients with tuberous sclerosis.

Adolescent↗

PubMed1996

Denture stomatitis: quantification of interleukin-2 production by mononuclear blood cells cultured with Candida albicans.

Denture stomatitis is usually associated with the presence of yeast, particularly Candida albicans, and several bacteria. In this study mononuclear blood cells were grown in the presence of Candida albicans from a single colony, and interleukin-2 production induced in T lymphocytes was measured. Blood cells were from a population of patients with denture stomatitis and a control group of denture wearers without stomatitis. Induction of interleukin-2 production was correlated with factors that condition denture stomatitis, namely, isolation of Candida albicans in selective medium, age of the denture, and diabetes. Concentrations of interleukin-2 in supernatant and serum were also compared. Significant differences in interleukin-2 production were found between patients with denture stomatitis and controls. Statistical analysis demonstrated a significant association between isolation of Candida albicans and elevated interleukin-2 production in cultures from patients with and without denture stomatitis.

Adult↗

PubMed1991

Phagocytosis and adhesiveness of peripheral blood polymorphonuclear leukocytes in patients with rapidly progressive periodontitis.

Phagocytosis and adhesiveness of peripheral blood polymorphonuclear leukocytes were studied in patients diagnosed with generalized rapidly progressive (form A) periodontitis. All patients belonged to a single family and were first degree relatives. In the patients' leukocytes there was a statistically significant reduction in phagocytic index and adhesiveness, in comparison with leukocytes from controls. However, adhesiveness approached control values in the presence of autologous serum, thus implying that serologic factors may enhance this function in patients with this type of periodontitis.

Adult↗

PubMedDate not supplied

Determination of cell membrane bound IgE in allergic patients and healthy controls. A new technology.

Cell membrane bound IgE was determined in 44 allergic patients and 34 healthy controls with a radiobinding technique using I-125 labeled anti-IgE as a marker. The technique possesses an intraassay variability of 10% and an interassay variability of 20%. Owing to the possibility that anti-IgE may bind to the cell membrane via the Fc receptor, IgE was detached from the membrane by gradually reducing pH to 4 and quantitating bound anti-IgE. This procedure led to an 83 +/- 14.23% drop in I-125 anti-IgE uptake. However, other cell markers tested (OKT-3, OKT-4, IgG) as well as cell viability remained unchanged, thus demonstrating the high degree of specific labeled anti-IgE uptake by IgE molecules on the cell membrane. The results presented to date support the usefulness of the technique described. Hence, bound IgE was determined in allergic subjects and controls, and correlated to the free serum levels of IgE. The results show that greater quantities of IgE are found on the cell membranes of allergic patients in comparison to the control population. In 81% of the former, uptake surpassed 3% of the total amount of isotope added, whereas 85% of the control subjects showed less than 3% uptake. No statistically significant correlation was obtained between serum IgE (UI/ml) and bound IgE levels in allergic subjects. Double immunofluorescence assays demonstrated the presence of cells with surface-bound IgE (s IgE +) which also expressed HLA class II (DR) molecules. Protein synthesis blocking studies showed IgE on the cell membrane to have a predominantly carrier role.

Antibodies, Anti-Idiotypic↗

PubMedDate not supplied

Melatonin: implications at the oral level.

The strong relationship between the pineal gland and the immune system continues to establish itself more and more. In situations of a pinealectomy or in those of inhibition of the production of melatonin, a state of immunosuppression is produced which disappears when the patient receives this hormone. Likewise, melatonin counteracts the negative effects that immunosuppressive drug treatment produce over the immunity. It is due to these facts that one postulates the possibility of utilizing melatonin in primary and secondary immunodeficiency states as well as in cancerous immunotherapy. The action of this hormone over the immune system is carried out through the T-helper lymphocytes, lymphokines and also it seems through certain pituitary hormones. On the other hand, lymphokines such as gamma-interferon and interleukin-2, as well as the thymus, can modulate the synthesis of melatonin at the level of the pineal gland. Without doubt, all these actions have important consequences at the time of treatment of our high-risk dental patients who have, in one way or another, an altered immunologic system. The altered immune system has direct implications in primary oral pathologies, or in others derived directly from our dental treatment.

Adjuvants, Immunologic↗