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A D Argoudelis

Publications and source records attributed to A D Argoudelis.

53 records · Page 3Linked to original sources
PubMed1971

Microbial transformation of antibiotics: phosphorylation of clindamycin by Streptomyces coelicolor Müller.

Addition of clindamycin to whole-cell cultures of Streptomyces coelicolor Müller resulted in the loss of in vitro activity against organisms sensitive to clindamycin. Incubation of such culture filtrates with alkaline phosphatase generated a biologically active material identified as clindamycin. Fermentation broths containing inactivated clindamycin yielded clindamycin 3-phosphate, the structure of which was established by physical-chemical and enzymatic studies. Clindamycin was phosphorylated by lysates and partially purified enzyme preparations from S. coelicolor Müller. These reactions require a ribonucleoside triphosphate and Mg(2+). The product of the cell-free reactions was identified as clindamycin 3-phosphate.

Adenosine Triphosphate↗