Biomedical subjects

A D Bakuridze

Publications and source records attributed to A D Bakuridze.

3 recordsLinked to original sources

PubMed2006

[Dissolution study of the gentin tablets].

To establish individual dissolution test for the tablets gentin, which have a marked influence on the secretory function of the stomach (increase the free acidity of the gastric juice and stimulate enzymoproduction function of the stomach), and gastroprotective functioning, the conditions for the test realization were studied and specified, using apparatus "Rotating Basket" (Dissolution test, apparatus 1, p.1791, USP XXIII, 1995). For the quantification of the active ingredients in buffer solutions chromatospectrophotometric method was used. The same conditions were used for the accomplishment of the dissolution test using apparatus "Rotating Paddle" (Dissolution test, apparatus 2, p.1791, USP XXIII, 1995). Metrologic characteristics were compared for the evaluation of the reproducibility of the results. Obtained data showed better reproducibility of the results for the apparatus "Rotating Paddle" compare to the apparatus "Rotating Basket". Estimated conditions are useful for the routine control of the tablets "Gentin" in the case of manufacturing.

Buffers↗

PubMed2006

[Optimisation of the conditions of particle sizing of gentamicin sulfate].

One of the problems for the development of dry powder inhalation preparations is evaluation of particle size distribution of obtained micronized powders for the determination of theoretical aerodynamic diameter of the particles. The final aim of our study is the development of inhalation dry powder formulation of gentamicin sulfate, therefore it is necessary to determine theoretical aerodynamic diameter of micronized gentamicin sulfate particles. Micronized gentamicin sulfate powders are very cohesive and do not have satisfactory flow properties, the shape of the particles is close to spherical. The most suitable technique for this kind of powders is laser diffraction. On the basis of realized experiments the optimal conditions for the determination of particle size distribution of gentamicin powders were found. Results are in accordance with the data obtained by method-reference (Electron Microscopy).

Administration, Inhalation↗

PubMed1994

[Ecological immunodeficiency: immunogenetic aspects of its etiology and correction].

The examinations of auto-transport Kazakh drivers have indicated that there is a significant reduction in some immunological parameters HLA-B5 and HLA-DR5-proliferative responses of lymphocytes to mitogens, production of interleukin-1 and interleukin-2, activity of NK and LAK-cells. It is suggested that these impairments occur with their long-term exposure to automobile transport effluents (ATE), since the same changes in immunological parameters were found previously in the experiments with animals exposed to ATE for a long time. Some of the detected immunoresponsive disorders are associated with the availability of definite HLA antigens, such as HLA-B5 and HLA-P5. The new immunomodulating agents thymohexin (TH) and phyto-extraction drugs C4 and C6 used in vitro substantially restored the lower functional activity of immunocompetent cells and production of cytokines (thymohexin was particularly effective). The most marked recovery was observed in the drivers with the phenotype HLA-B6+ and HLA-P5+, i.e. in persons with maximally ATE-reduced immunological parameters.

Adjuvants, Immunologic↗