THE "LATE" ANAEMIA OF HAEMOLYTIC DISEASE OF THE NEWBORN.
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Biomedical subjects
Publications and source records attributed to A D HURDLE.
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Using a short series of biochemical tests already in use in many routine laboratories, it is possible to identify strains of the genus Klebsiella and to differentiate K. aerogenes from other types. Marked production of slime is not peculiar to the group and colonial appearance alone is not a satisfactory basis for identification. K. aerogenes is the type most commonly isolated from all clinical specimens. It is suggested that the name may be retained in clinical bacteriology and used when applicable, particularly when reporting urinary strains. K. aerogenes is of doubtful pathogenicity when isolated from sputum; frequently its appearance follows antibiotic treatment for other organisms. It should be clearly distinguished from other Klebsiella types occurring as primary pathogens in sputum. Friedlander's bacillus is considered a suitable collective term for the latter, namely K. edwardsii-edwardsii, K. pneumoniae, and K. edwardsii-atlantae. The clinical significance of K. rhinoscleromatis and K. ozaenae could not be assessed as so few isolations were made. On the rare occasions when they occur they would, with the tests recommended, be included as Friedlander's bacillus, the distinction not being readily made in the clinical laboratory.
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Estimations of red cell and blood volumes using (51)Cr were carried out on a group of 37 people over the age of 70 who were not anaemic. Subjects with clinical conditions known to affect red cell production were excluded. The mean values for red cell and blood volumes were found to be comparable with those of a control group of young adults. Seven people had red cell volumes below the accepted range in young adults but no reason was found for this difference. Red cell survival was determined concurrently on 11 of the group and did not differ from those of young controls.
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