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Biomedical subjects

A D Kay

Publications and source records attributed to A D Kay.

22 records · Page 2Linked to original sources
PubMed1984

Combined immunochemical and electrophoretic determinations of proteins in paired serum and cerebrospinal fluid samples.

Albumin and immunoglobulin G were simultaneously determined in paired serum and cerebrospinal fluid samples from healthy volunteers. The albumin quotient and the IgG index were calculated to establish normal values. High-resolution electrophoresis was also performed with the same samples and the electrophoretic patterns were correlated with the numerical values to improve the reliability of the test results. Representative examples from abnormal conditions are also shown, to illustrate the increased accuracy and useful applications of this combined analysis in the diagnosis of neurological conditions.

Adult↗
PubMed1983

Down's syndrome in adults: brain metabolism.

The cerebral metabolic rate for glucose, as measured with positron emission tomography and fluorine-18-labeled 2-deoxy-D-glucose, was significantly higher in four healthy young subjects with trisomy 21 syndrome (Down's syndrome) than the mean rate in healthy young controls. The rate of cerebral glucose utilization in the frontal lobe of a 51-year-old subject with Down's syndrome was significantly lower than the rate in the young subjects with this syndrome, but approximated the rate in middle-aged controls. Thus glucose utilization by the brain appears to be excessive in young adults with Down's syndrome but may decline with age in some brain regions.

Adult↗
PubMedDate not supplied

CSF and serum concentrations of albumin and IgG in Alzheimer's disease.

Cerebrospinal fluid (CSF) and serum concentrations of albumin and immunoglobulin G (IgG) were measured in 31 patients with presumptive Alzheimer's disease (AD) and in 14 healthy control subjects. The albumin and IgG quotients, and IgG index were calculated to evaluate the permeability of the blood-brain barrier and the intrathecal production of immunoglobulins. X-ray computerized tomography (CT) of the head was performed to investigate the relation between cerebral atrophy and CSF protein concentrations. The albumin and IgG quotients, and the IgG index did not differ significantly between the AD and control groups. Cerebral atrophy, as measured by CSF volume, was not related to CSF protein concentrations in either group. The results do not support the hypothesized roles of blood-brain barrier disruption or of immunologically-mediated injury of the central nervous system in the pathogenesis of AD.

Aged↗