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Biomedical subjects

A D Kuimov

Publications and source records attributed to A D Kuimov.

At least 19 recordsLinked to original sources
PubMed2006

[The combination of carbohydrate and porphyrinic exchange disturbances: is it a chance or regularity?].

The subjects of the study were 399 patients with internal diseases and metabolic disturbances. Carbohydrate exchange parameters (fasting level of capillary blood glucose and glucose tolerance test), and porphyrin fractions in urine (uroporphyrin, coproporphyrin), and feces (protoporphyrin, coproporphyrin) were measured. Hepatic type of porphyrinic dysmetabolism was registered in 201 (50.4%) patients. Out of these patients, 38 had disturbances corresponding to the criteria of symptomatic elevation of fecal porphyrin level, 28 had secondary coproporphyrinuria, 40 had latent, and 95 had manifest late cutaneous porphyria. In patients with normal porphyrinic exchange, the frequency of carbohydrate exchange disturbances did not exceed 6%, while in patients with different variants of porphyrinic dysmetabolism it was almost 40%. The results show that patients with hepatic type of porphyrinic dysmetabolism should be considered to have a higher risk of the development of diabetes mellitus and other carbohydrate disorders.

Adolescent↗
PubMed2006

[Differential diagnosis of specific gastric lesions in early syphilis patients with helicobacter infection].

AIM: To evaluate differential-diagnostic significance of different clinical signs, endoscopic and serological studies in making diagnosis of early gastric syphilis (EGS) in patients with helicobacter infection. MATERIAL AND METHODS: Thirty patients were hospitalized with diagnosis of gastric and/or duodenal ulcer. Helicobacter pylori was identified morphologically or with a rapid urease test. Syphilis was rejected when microprecipitation reaction was negative and confirmed with Wassermann reaction. The patients received standard treatment including a course of eradication therapy. RESULTS: Endoscopic examination discovered single and multiple ulcers in 25 and 5 patients, respectively, located in the stomach and duodenum. A rapid test for syphilis produced negative and positive results in 28 and 2 patients, respectively. Twenty two patients tolerated eradication therapy well. Positive results were achieved in 19 (84.6%) patients. Six patients had side effects (pruritus, urticaria, dyspepsia) on eradication treatment day 2-3. Jarisch-Herxheimer reaction (elevated body temperature 38-38.6 degrees C) and roseola eruption were observed in 2 (6.7%) patients with positive serological reactions for syphilis on the first day of eradication therapy. CONCLUSION: Diagnostic criteria of EGS are the following: serologically confirmed manifest or latent syphilis, poor effect of standard antiulcer treatment, rapid elimination of the disease symptoms in antisyphilis therapy and positive changes in pathological alterations in gastric mucosa.

Adult↗
PubMed2003

[Myocardial infarction in women: risk factors and clinical features].

The course of myocardial infarction (MI) in women, especially 60 years of age and older, is characterized by such severe complications as cardiorrhexis, hypovolemic cardiogenic shock, asystole, recurrent ventricular fibrillation and electromechanic dissociation responsible for the majority of lethal outcomes. Especially high MI lethality is in women at the age 70-79 years who have also the highest incidence of recurrent macrofocal MI while small-focal MI occurs in women over 80 years of age (80-89) more frequently than in 60-year-olds and younger. Dominating MI risk factors in women were the following: arterial hypertension detected in 81% patients under 60 and 90.8% cases over 60 years; abnormal lipid spectrum of blood including hypercholesterolemia (HCE), hypertriglyceridemia (HTE) and low concentration of HDLP cholesterol. HCE and HTE closely correlated with abdominal obesity irrespectively of age. Early menopause in women under 60 and diabetes mellitus of type 2 in older women, accumulation of two and more factors of risk contribute to development of coronary heart disease and MI, in females.

Adult↗
PubMed1999

[Trimetazidine effects on exercise tolerance and left ventricular diastolic function in patients with coronary heart disease].

AIM: Trial of trimetasidine effects on exercise tolerance (ET) and left ventricular diastolic function (LVDF) in patients with coronary heart disease (CHD). MATERIALS AND METHODS: The study group included 40 CHD patients. Of them 10, 18 and 12 had myocardial infarction, unstable angina pectoris and stable angina, respectively. 38 CHD patients of the control group had these disorders, respectively, in 5, 15 and 18 cases. 2-3-month therapy with nitrates, beta-blockers (BB) and inhibitors of angiotensin-converting enzyme (ACE) was given to both groups with adjuvant trimetasidine (60 mg/d) given to patients of the study group. The effects were judged by the results of cycle exercise tests and echo-CG including the loading one. RESULTS: Adjuvant use of trimetasidine improved exercise tolerance, mean threshold capacity, LVDF. When added to BB treatment, trimetasidine reduced damage to LVDF under dipiridamol test. CONCLUSION: Trimetasidine addition to combined treatment of CHD raises exercise tolerance and improves LVDF.

Adrenergic beta-Antagonists↗
PubMed1994

[The diagnostic and prognostic assessment of the changes in lysosomal enzymatic activity in the blood of patients with acute myocardial infarct and unstable stenocardia].

Serum activity of five lysosomal marker enzymes was measured in patients with acute myocardial infarction (AMI) and unstable angina pectoris (UAP) with consideration of the disease severity. A significant increase of enzyme activity was found both in patients with UAP and AMI on the first day of hospitalization. The enzymes activity was higher in patients with more severe form of AMI. Lysosomal enzyme activity was closely related to severity of the disease: clinical improvement occurred in patients with decreased activity (on day 7-10), while in aggravation of the disease lysosomal hyperenzymemia stayed high up to the end of the observation period (on day 30). The above findings demonstrate feasibility of using lysosomal enzymes test both for differentiation between AMI and UAP and for predicting the disease recurrences.

Adult↗
PubMed1991

[Glucocorticoid function of the adrenal cortex in patients with myocardial infarction: study of elimination of exogenous cortisol].

The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction. It is concluded that the nature of cortisol elimination may reflect the natural history and prediction of myocardial infarction. In terms of the body tissue demand, two type of elimination are identified: retarded (a favorable type) and accelerated (an unfavorable type). The data on the nature of cortisol elimination may serve as an indication for glucocorticoid therapy. The baseline cortisol concentrations fail to reflect the nature of glucocorticoid metabolism in patients with myocardial infarction.

Adrenal Cortex↗
PubMed1983

[Dynamics of the level of insulin in blood in response to hydrocortisone loading in myocardial infarction].

To elucidate the details of carbohydrate metabolism in the course of acute myocardial infarction, baseline blood insulin and glucose levels and changes thereof in response to acute hydrocortisone loading were investigated in patients with acute transmural and large-focal myocardial infarction that had developed in the presence of essential hypertension (patients with diabetes mellitus were excluded from the study). Basal hypoinsulinemia was discovered on Day 1 of myocardial infarction in these patients. On Days 3-5 of infarction, blood insulin concentration was increased significantly. The pattern of hydrocortisone-induced changes in glucose level suggests glucocorticoid involvement in "urgent" glucose mobilization. The state of and associations between the two hormonal systems throughout acute myocardial infarction are discussed on the basis of changes in insulin and glucose levels under hydrocortisone load.

Adult↗